Vakkaş Korkmaz

Memorial Ankara Hospital

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CÇ

Caner Çakır

Zübeyde Hanim Maternity Hospital

Yaprak Engin Üstün

Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi

Taner Turan

Sağlık Bilimleri Üniversitesi

Günsu Kimyon Cömert

Sağlık Bilimleri Üniversitesi

Fatih Kılıç

Ankara Mevki Asker Hastanesi

Tuncay Küçüközkan

Sağlık Bilimleri Üniversitesi

EÖ

Enis Özkaya

Zeynep Kamil Hospital

Nurettin Boran

Zübeyde Hanim Maternity Hospital

ÇK

Çiğdem Kılıç

Zübeyde Hanim Maternity Hospital

Dilek Yüksel

Sağlık Bilimleri Üniversitesi

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Sağlık Bilimleri Üniversitesi

166

Hudson Institute

107

Zübeyde Hanim Maternity Hospital

Ministry of Health

University of Health Sciences

University of Health Science

Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi

Memorial Ankara Hospital

Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi

Bilkent University

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Prognostic factors of adult granulosa cell tumors of the ovary: a Turkish retrospective multicenter study

Journal of Gynecologic Oncology (2023)

Okan Oktar Vakkaş Korkmaz Abdurrahman Alp Tokalıoğlu Çağatayhan Öztürk Özgür Erdoğan

To define the clinical, histopathological features and the prognostic factors affecting survival in patients with adult granulosa cell tumors of the ovary (AGCT).

10.3802/jgo.2024.35.e39

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Retrospective Analysis of Pure Ovarian Immature Teratoma in Patients Aged 15–39 Years: A Turkish Multicenter Study

Journal of Adolescent and Young Adult Oncology (2020)

Dilek Yüksel Sevgi Ayhan Vakkaş Korkmaz Caner Çakır Çiğdem Kılıç

Purpose: To evaluate the clinicopathological characteristics and surgical outcomes in patients with pure ovarian immature teratomas (POITs). Materials and Methods: In this multicenter study, a retrospective review was made of the databases of six Gynecology Oncology Departments in Turkey to identify patients with POITs who had undergone surgery between 1993 and 2019. Results: Evaluation was made of 48 patients with a median age at diagnosis of 22.5 years (range, 15-37 years). In 40 (83%) patients, stage I was determined and in eight patients, an advanced stage (IIIB, IIIC, and IVB) was determined. Tumors were found to be grade I in 17 (35.4%) cases, grade II in 12 (25%), and grade III in 19 (39.6%). Fertility-sparing surgery was applied to 42 (87.5%) patients and radical surgery to 6 (12.5%). The median follow-up was 60 months (range, 3-246 months). Recurrence was seen in seven patients, all with grade III tumors. In the final pathological examination of recurrent tumors, mature teratoma was reported in five patients, and immature teratoma in one patient. Salvage surgery was not performed in one patient as the tumor was unresectable and so a regimen of bleomycin, etoposide, and cisplatin (BEP) was administered. Conclusion: POITs are rare tumors seen at a young age, and benign or malignant relapse can be seen in these tumors. In this cohort, the malignant recurrence rate was 4.1%, and the benign recurrence rate was 10.4%. All the recurrences were in grade III tumors. Benign recurrences can be treated with surgery alone and the malignant group should be treated with surgery followed by chemotherapy.

Immature teratoma

Regimen

Radical surgery

10.1089/jayao.2020.0155

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Comparison Of Hematologic Parameters In Patients With Positive vs. Negative Surgical Margins After Conization

Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi (2018)

İbrahim Ertuğrul Yalçın Mustafa Erkan Sarı Hanifi Şahin Vakkaş Korkmaz Nazlı Topfedaisi Özkan

Cervical conization

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Utility of superior mesenteric artery Doppler and maternal pancreatic size for predicting gestational diabetes mellitus

Irish Journal of Medical Science (1971 -) (2014)

Alptekin Tosun Soner Düzgüner Enis Özkaya Vakkaş Korkmaz Şencan Acar

10.1007/s11845-014-1155-7

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Determination of the Relationship Between Serum Lactate Level and Antenatal Complications and Early Neonatal Outcomes In Hyperemesis Gravidarum Patients

Eurasian Journal of Medicine and Oncology (2018)

Ezgi Turgut Uğurkan Erkayıran Burak Karadağ Vakkaş Korkmaz

Hyperemesis gravidarum

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UTERİN SERÖZ KARSİNOM VE UTERİN BERRAK HÜCRELİ KARSİNOM TANISI ALAN HASTALARDA KLİNİKOPATOLOJİK ÖZELLİKLERİN VE SAĞ KALIM SONUÇLARININ KARŞILAŞTIRILMASI Comparison Of Clinicopathologic Characteristics And Survivals In Patients With Uterine Serous And Clear Cell Carcinoma

Bozok Tıp Dergisi (2020)

Zeliha Fırat Cüylan Koray Aslan Vakkaş Korkmaz Murat Öz Mehmet Mutlu Meydanlı

OZET Amac: Uterin seroz karsinom (USK) ve uterin berrak hucreli karsinomlarin (UBHK) klinikopatolojik ozelliklerinin ve hastalarin sag kalim sonuclarinin karsilastirilmasi amaclanmistir. Gerec ve Yontem: Final patoloji raporlarina gore, USK ve UBHK tanisi alan hastalar calisma grubunu olusturmaktadir. Demografik, kilnikopatolojik ve sagkalim verileri analiz edildi. Bulgular: USK grubunda 69 ve UBHK grubunda 36 hasta analiz edildi. USK grubunda hastalarin UBHK grubundaki hastalarla karsilastirildiginda, istatistiksel olarak anlamli derecede daha ileri evre hastaligi sahip oldugu saptandi (sirasiyla %61,1 ve %36,2, p=0.015). USK grubundaki hastalarin UBHK grubundaki hastalar ile karsilastirildiginda daha fazla omental metastaza (17/69 ve 2/36, p=0,016) ve peritoneal sitoloji pozitifligine (25/69 ve 5/36, p=0,016) sahip oldugu bulundu. Tum kohort icin multivaryan analizde sadece peritoneal sitoloji pozitifliginin azalmis hastaliksiz sagkalim (DFS) icin bagimsiz risk faktoru oldugu bulundu (HR 5,07 95% CI 2,07-12,42; p<0,001). Tum kohort icin, multivaryan analizde sadece peritoneal sitolojinin pozitif olmasi azalmis kaba sagkalim (OS) icin bagimsiz risk faktoru olarak bulundu (HR 3,50 95% CI 1,31-9,33; p=0,012). Sonuc: Sonuc olarak calismamizda USK ve UBHK tanisi alan hastalarda sitoloji pozitifligini hem DFS hem de OS icin bagimsiz prognostik faktor olarak saptadik. Ayrica USK grubundaki hastalarda omental metastaz oranlarinin yuksek olmasi nedeniyle omentektominin cerrahi evrelemenin bir komponenti olmasi gerektigini dusunmekteyiz. Anahtar kelimeler: Endometriyal karsinom; Uterin berrak hucreli karsinom; Uterin seroz karsinom. ABSTRACT Aim: We aimed to compare the clinicopathological characteristics and survivals between uterine serous carcinoma (USC) and uterine clear cell carcinoma (UCCC). Materials and Methods: The study population consists of women who were diagnosed with USC and UCCC according to the final pathology reports. Demographic, clinicopathological and survival data were collected and analyzed. Results: A total of 69 patients with USC and 36 patients with UCCC were included in the final analysis. Patients in the USC group tend to have more advanced stage disease compared to the patients in the UCCC group and this was statistically significant between the groups (61.1% vs 36.2%, respectively; p=0.015). Patients with USC were more likely to have omental metastasis (17/69 vs 2/36, p=0.016) and positive peritoneal cytology (25/69 vs 5/36, p=0.016). In the multivariate analysis, only positive peritoneal cytology remained as an independent prognostic factor for decreased disease free survival (DFS) for the entire cohort (HR 5.07, 95% CI 2.07-12.42; p<0.001). Only positive peritoneal cytology was an independent prognostic factor for decreased overall survival (OS) for the entire cohort (HR 3.50, 95% CI 1.31-9.33; p=0.012) in the multivariate analysis. Conclusion: We concluded that positive peritoneal cytology was an independent prognostic factor for both DFS and OS in patients with USC and UCCC in the current study. Because of the high rate of omental metastasis in the USC group, we also suggest performing an omentectomy as a part of the comprehensive surgical staging surgery. Key words: Endometrial carcinoma; Uterine clear cell carcinoma; Uterine serous carcinoma

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Does coexistence of endometrial cancer and adenomyosis affect survival outcomes? A retrospective cohort study

European Journal of Gynaecological Oncology (2023)

Latife Gözde Buyuksahin Azize Cemre ÖZTÜRK Vakkaş Korkmaz Şadıman Kiykaç Altinbaş Yaprak Engin Üstün

The aim of this study is to investigate cancer survival parameters in patients with a combination of adenomyosis and endometrial carcinoma in pathological specimens. This is a retrospective cohort study conducted in a tertiary health center. Between January 2010 and December 2016, a total of 370 patients with a diagnosis of endometrial carcinoma who had undergone at least total abdominal hysterectomy and bilateral salpingoopherectomy. After excluding the patients from the pathology after reviewing the reports, 76 patients with adenomyosis were included in the study group and 287 patients without adenomyosis were included in the control group. The mean age of all patients was 63.6 ± 8.2 years. The mortality rate was 9.2% in patients with adenomyosis and 12.9% in patients without adenomyosis (p = 0.382). Overall, the mean time from diagnosis to death was 41.8 ± 24.7 months, which did not differ between patients with adenomyosis (29.3 ± 18 months) and without adenomyosis (44.6 ± 25.4 months, (p = 0.117). The presence of adenomyosis did not significantly affect overall survival (p = 0.434) or disease-free survival (p = 0.146). Median disease-free survival was 119 months in patients without adenomyosis and 120 months in patients with adenomyosis. None of the factors we studied affected survival in patients with adenomyosis. In our study, the presence of adenomyosis was found in 20.9% of patients who underwent hysterectomy for endometrial cancer, and this association had neither a positive nor a negative impact on disease prognosis, i.e., mortality rate, disease-free survival and overall survival.

Adenomyosis

10.22514/ejgo.2023.112

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Uterusa sınırlı karsinosarkom ve grade 3 endometrioid endometrium kanserinin klinikopatolojik ve sağkalım analizlerinin karşılaştırılması

Türk Kadın Sağlığı ve Neonatoloji Dergisi (2021)

Caner Çakır Vakkaş Korkmaz Çiğdem Kılıç Dilek Yüksel Mehmet Ünsal

Amaç: Grade 3 endometrioid endometrium kanseri (G3ECC) ve karsinosarkom (KS), ESMO-ESGO-ESRTO’un 2015’de yayınladığı konsensüsunda endometrium kanseri olguları içinde aynı risk grubunda yer alsa da, bu histolojik tiplerin biyolojik davranışları farklıdır. Bu çalışmada G3ECC olguları ile uterusa sınırlı KS vakalarının klinik sonuçlar ve sağkalım analizleri açısından karşılaştırılması amaçlandı.Gereç ve Yöntem: Uterusa sınırlı hastalığı olan G3ECC olguları (n=67) ile uterusa sınırlı karsinosarkom (KS) olguları (n=54) klinik sonuçları ve sağkalım analizleri açısından karşılaştırıldı.Bulgular: Uterusa sınırlı hastalık olmasına rağmen KS olan hastalarda sağkalımın belirgin kötü olduğu görüldü. Rekürrens G3ECC’de %10,5 iken, KS’da bu oran %27,8 olarak saptandı (p=0,011). Sonuç: Karsinosarkomlar erken evrede dahi G3 endometrioid endometrium kanserlerinden daha kötü prognoza sahip olabilirler.

10.46969/ezh.753136

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Neoadjuvant chemotherapy for locally advanced stage (IB2-IIA2-IIB) cervical carcinoma: Experience of a tertiary center and comprehensive review of the literature

Journal of Turkish Society of Obstetric and Gynecology (2021)

Caner Çakır Fatih Kılıç Rıza Dur Dilek Yüksel Mehmet Ünsal

This study evaluated the outcomes of neoadjuvant chemotherapy

Center (category theory)

10.4274/tjod.galenos.2021.70493

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Fragmented QRS complexes in electrocardiogram and their relationship with somatic symptoms in postmenopausal women

Menopause The Journal of The North American Menopause Society (2025)

Büşra Körpe Caner Köse Nazlı Turan Serifler Vakkaş Korkmaz Hüseyin Levent Keskin

Abstract Objective Menopause significantly impacts cardiovascular health, yet the relationship between myocardial abnormalities and noncardiac symptoms in postmenopausal women remains underexplored. This study aims to investigate the association between fragmented QRS waves (fQRS) positivity on electrocardiograms (ECG) and somatic symptoms in postmenopausal women. Methods We included 623 postmenopausal women attending a menopause clinic for routine annual gynecological examinations. Women were categorized into fQRS-positive (n = 248) and fQRS-negative (n = 375) groups based on ECG results analyzed by a blinded cardiologist. The Menopause Rating Scale (MRS) was used to assess menopausal symptoms across three subscales: somatic, psychological, and urogenital. Data on demographics, physical activity, and medical history were also collected. Statistical analyses included comparisons of MRS scores, and a binary logistic regression analysis was used to identify the relationship between fQRS positivity and somatic symptoms. Adjusted models were created for potential confounders. Results Women with fQRS positivity reported significantly higher somatic symptoms and total MRS scores compared to those without fQRS positivity. Specifically, higher scores were observed in the fQRS-positive group for the somatic subscale and total MRS score. Binary logistic regression analysis revealed that fQRS positivity was significantly associated with somatic symptoms after adjusting for all confounders (odds ratio, 10.76; 95% CI, 7.21-16.07; P < 0.001). Conclusions Postmenopausal women with fQRS positivity on ECG exhibit a higher severity of somatic symptoms compared to those without fQRS positivity. These findings suggest a potential link between somatic symptoms and myocardial conduction abnormalities indicated by fQRS positivity. Further research is needed to clarify the underlying mechanisms of this association.

10.1097/gme.0000000000002491

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