Tamás Süli

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Máté Halas

Département Santé Animale

Eszter Mezei

National Center for Epidemiology

Orsolya Korbacska‐Kutasi

University of Veterinary Medicine Vienna

Péter Kertész

Anto Vrdoljak

Dechra Pharmaceuticals (United Kingdom)

Zsófia Lanszki

University of Pecs

Réka Boda

University of Pecs

Eduardo Fernández‐Carrión

Universidad Complutense de Madrid

Péter Malik

National Food Chain Safety Office

Ferenc Jakab

University of Pecs

Cooperative Institutions

University of Pecs

University of Veterinary Medicine

Magyar Agrár- és Élettudományi Egyetem

University of Veterinary Medicine Vienna

National Center for Epidemiology

Hungarian Academy of Sciences

National Food Chain Safety Office

National Public Health and Medical Officer Service

Universidad Complutense de Madrid

Madrid Health Service

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Body temperature and motion: Evaluation of an online monitoring system in pigs challenged with Porcine Reproductive & Respiratory Syndrome Virus

Research in Veterinary Science (2017)

Tamás Süli Máté Halas Zsófia Benyeda Réka Boda Sándór Belák

Rectal temperature

10.1016/j.rvsc.2017.09.021

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Vaccination of broilers against Newcastle disease in the presence of maternally derived antibodies

Tierärztliche Praxis Ausgabe G Großtiere / Nutztiere (2017)

Anto Vrdoljak Máté Halas Tamás Süli

Summary Objective: The aim of this study was to evaluate the efficacy of a live attenuated vaccine against Newcastle disease in broilers with different levels of maternally derived antibodies (MDA). While vaccination remains the single most important means for controlling Newcastle disease, presence of MDA may interfere with the vaccination of young birds and decrease the efficacy of the vaccine. Materials and methods: Day-old chicks with variable levels of MDA (negative, low and high) were vaccinated with a live attenuated vaccine against Newcastle disease. Three most commonly used inoculation routes were compared; oculonasal, spray and oral (drinking water). Onset and duration of immunity were measured by serology and challenge with virulent virus. Results: Immune response in vaccinated MDA-positive birds was delayed in comparison with SPF controls. Protection was well established already at 14 days post vaccination in SPF birds while in MDA-positive birds it was 1–2 weeks delayed and was lower throughout the study. Non-vaccinated MDA-positive birds lost passive protection completely at 3–4 weeks of age and were significantly more susceptible to challenge than vaccinated hatch mates at all test points. The protection rate increased in vaccinated birds towards the end of the experiment and reached 70–100 % at the last test points (35–42 days of age). Correlation of haemagglutination inhibition (HI) titre vs. protection rate revealed the importance of cellular and local immunity as most of the vaccinated birds with low HI titre were protected, contrary to their unvaccinated hatch mates with the same HI titre. Oculonasal route seems to provide slightly better protection than the other two routes. Conclusions and clinical relevance: Although immune protection in vaccinated MDA-positive birds may be decreased or delayed, vaccination still provides high protection against ND challenge in comparison with the unvaccinated hatch mates. The degree of interference seems to be proportional to the level of MDA. Vaccination schedules therefore need to be designed according to the immune status of the flock.

Newcastle Disease

Antibody titer

Attenuated vaccine

10.15653/tpg-160661

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Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018

Viruses (2020)

Brigitta Zana Károly Erdélyi Anna Nagy Eszter Mezei Orsolya Nagy

The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of the virus to environmental conditions. The year of 2018 was characterized by an extraordinary increase in human and animal cases in the Central-Eastern European region, including Hungary. In a collaborative effort, we summarized and analyzed the genetic and serologic data of WNV infections from multiple Hungarian public health institutions, universities, and private organizations. We compared human and veterinary serologic data, along with NS5 and NS3 gene sequence data through 2018. Wild birds were excellent indicator species for WNV circulation in each year. Our efforts resulted in documenting the presence of multiple phylogenetic subclades with Balkans and Western-European progenitor sequences of WNV circulating among human and animal populations in Hungary prior to and during the 2018 epidemic. Supported by our sequence and phylogenetic data, the epidemic of 2018 was not caused by recently introduced WNV strains. Unfortunately, Hungary has no country-wide integrated surveillance system which would enable the analysis of related conditions and provide a comprehensive epidemiological picture. The One Health approach, involving multiple institutions and experts, should be implemented in order to fully understand ecological background factors driving the evolution of future epidemics.

West Nile virus

Pandemic

Genetic data

10.3390/v12010123

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Citations (15)