Ana Rita Carvalho

Cooperativa de Ensino Superior Politécnico e Universitário

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Maria Elizabeth Tiritan

Cooperativa de Ensino Superior Politécnico e Universitário

Cláudia Ribeiro

Cooperativa de Ensino Superior Politécnico e Universitário

Ariana Pérez‐Pereira

University of Trás-os-Montes and Alto Douro

João Soares Carrola

University of Trás-os-Montes and Alto Douro

Bruno B. Castro

University of Minho

Carla Fernandes

Universidade do Porto

Ana Rita Fernandes Miranda da Costa

Cooperativa de Ensino Superior Politécnico e Universitário

Virgínia M. F. Gonçalves

Cooperativa de Ensino Superior Politécnico e Universitário

Nídia Menezes

Polytechnic Institute of Viseu

Carlos Ribeiro

Museu da Lourinhã

Cooperative Institutions

Universidade do Porto

Cooperativa de Ensino Superior Politécnico e Universitário

Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde

Unidade em Ciências Biomoleculares Aplicadas

University of Aveiro

Rede de Química e Tecnologia

Centro Interdisciplinar de Investigação Marinha e Ambiental

University of Coimbra

Universidade Católica Portuguesa

University of Trás-os-Montes and Alto Douro

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MDMA effects on Daphnia magna morphophysiology: preliminary data

RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia (2022)

Ana Rita Fernandes Miranda da Costa Ariana Pérez‐Pereira Ana Rita Carvalho Bruno B. Castro João Soares Carrola

e disponibilizadas em 1935, as sulfonamidas rapidamente foram associadas a curas "milagrosas" de várias doenças.

Daphnia magna

MDMA

10.51126/revsalus.v4isup.338

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Toxicity of butylone and its enantiomers to Daphnia magna and its degradation/toxicity potential using advanced oxidation technologies

Aquatic Toxicology (2024)

Ana Rita Carvalho Ana M. Morão Virgínia M. F. Gonçalves Maria Elizabeth Tiritan Ana M. Gorito

Butylone (BTL) is a chiral synthetic cathinone available as a racemate and reported as contaminant in wastewater effluents. However, there are no studies on its impact on ecosystems and possible enantioselectivity in ecotoxicity. This work aimed to evaluate: (i) the possible ecotoxicity of BTL as racemate or its isolated (R)- and (S)- enantiomers using Daphnia magna; and (ii) the efficiency of advanced oxidation technologies (AOTs) in the removal of BTL and reduction of toxic effects caused by wastewaters. Enantiomers of BTL were obtained by liquid chromatography (LC) using a chiral semi-preparative column. Enantiomeric purity of each enantiomer was > 97 %. For toxicity assessment, a 9-day sub-chronic assay was performed with the racemate (at 0.10, 1.0 or 10 μg L

Daphnia magna

Ecotoxicity

10.1016/j.aquatox.2024.106906

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Citations (4)

Manchas de Roth em paciente com linfoma: um relato de caso

Brazilian Journal of Health Review (2025)

Vitória Chiodi Pereira Ana Rita Carvalho Carlos Trindade Cristina Ribeiro Patricia C. B. Beltrão Braga

As manchas de Roth são achados oculares caracterizados por hemorragia retiniana com centro branco. Originalmente descritas em associação com endocardite bacteriana, elas estão, na verdade, presentes em uma miríade de doenças, inclusive em doenças hematológicas, como leucemia, onde são mais comumente encontradas, e linfoma, onde seu achado é mais raro. Tendo em vista os diversos diagnósticos diferenciais etiológicos das Manchas de Roth, o presente relato de caso objetiva recapitula-los e fazer um recorte sobre as condições de seu aparecimento em um caso de linfoma. Para isso, foi realizada uma revisão da literatura, buscando as diferentes doenças associadas ao achado, e também algum outro caso de linfoma em que houve manifestação ocular com hemorragias de centro branco. As doenças mais comumente relacionadas às manchas de Roth foram Endocardite infecciosa, principalmente bacteriana; Hemorragia intra-craniana; HIV/AIDS, principalmente em paciente que estão severamente imunossuprimidos ou que apresentam complicações hematológicas; Anemia Severa e distúrbios hematológicos, Além disso, encontrou-se apenas um caso de manchas de Roth, em uma paciente com linfoma de células T, infectada pelo HIV e com anemia severa, provável motivo pelo qual apresentava as hemorragias de centro branco retiniano. Assim, concluiu-se que a presença de manchas de Roth deve suscitar a elaboração criteriosa de diagnósticos diferenciais, pois, em alguns casos, a presença dessas hemorragias pode ser o primeiro sinal de uma doença potencialmente grave e fatal (LING; JAMES 1998; KUMAR et al, 2023; LAIMON et al, 2024).

10.34119/bjhrv8n1-252

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Toxicity of the 3,4-Methylenedioxymethamphetamine and Its Enantiomers to Daphnia magna after Isolation by Semipreparative Chromatography

Molecules (2023)

Ana Rita Fernandes Miranda da Costa Virgínia M. F. Gonçalves Bruno B. Castro João Soares Carrola Ivan Langa

MDMA (3,4-methylenedioxymethamphetamine) is a chiral psychoactive recreational drug sold in illicit markets as racemate. Studies on the impact of MDMA on aquatic organisms are scarce. While enantioselectivity in toxicity in animals and humans has been reported, none is reported on aquatic organisms. This study aimed to investigate the ecotoxicological effects of MDMA and its enantiomers in Daphnia magna. For that, enantiomers (enantiomeric purity > 97%) were separated by liquid chromatography using a homemade semipreparative chiral column. Daphnids were exposed to three concentrations of (R,S)-MDMA (0.1, 1.0 and 10.0 µg L−1) and two concentrations of (R)- and (S)-enantiomers (0.1 and 1.0 µg L−1) over the course of 8 days. Morphophysiological responses were dependent on the substance form and daphnia development stage, and they were overall not affected by the (R)-enantiomer. Changes in swimming behaviour were observed for both the racemate and its enantiomers, but enantioselective effects were not observed. Reproductive or biochemical changes were not observed for enantiomers whereas a significant decrease in acetylcholinesterase and catalase activity was noted at the highest concentration of (R,S)-MDMA (10 µg L−1). Overall, this study showed that sub-chronic exposure to MDMA racemate and its enantiomers can interfere with morphophysiological and swimming behaviour of D. magna. In general, the (R)-enantiomer demonstrated less toxicity than the (S)-enantiomer.

Daphnia magna

MDMA

10.3390/molecules28031457

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Assessment of effluents quality through ecotoxicological assays: evaluation of three wastewater treatment plants with different technologies

Environmental Science and Pollution Research (2021)

Ana Rita Carvalho Ariana Pérez‐Pereira Cristina Couto Maria Elizabeth Tiritan Cláudia Ribeiro

Ecotoxicity

Daphnia magna

10.1007/s11356-021-15671-y

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Enantioselective ecotoxicity of promethazine in two freshwater organisms: daphnia (Daphnia magna) and zebrafish (Danio rerio)

Environmental Toxicology and Chemistry (2025)

Maria Miguel Coelho Ondina Ribeiro Ana Rita Carvalho Ariana Pérez‐Pereira Cláudia Ribeiro

Abstract Chiral pharmaceuticals, racemic or enantiomerically pure forms and their metabolites, can reach aquatic ecosystems via wastewater effluents (inefficient treatment operations) or by direct human disposal. They may negatively affect nontarget organisms even at low environmental concentrations. To make an accurate risk evaluation, the (eco)toxicity of both enantiomers needs to be assessed. Promethazine (PMZ) is a chiral antihistamine that has been detected in aquatic ecosystems owing to its high consumption. Promethazine undergoes metabolism in the liver, producing chiral metabolites such as promethazine sulfoxide (PMZSO) and N-desmethylpromethazine (DMPMZ) that reach water bodies. However, knowledge regarding the enantioselective toxicity of PMZ and its metabolites on aquatic organisms is missing. This study aimed to explore the potential enantioselective toxicity of PMZ and its metabolites on two relevant freshwater organisms, daphniid and fish, representing different trophic levels. The half maximal effect concentrations (EC50s) in Daphnia magna of PMZ, DMPMZ, and PMZSO were 2.33, 2.31, > 4 mg L−1, respectively, > 4 and 2.50 mg L−1 for (R) and (S)-PMZ, respectively, and > 4 mg L−1 for the enantiomers of DMPMZ and PMZSO. In studies involving zebrafish, Danio rerio, (R, S)-PMZ showed a median lethal concentration (LC50) of .72 mg L−1, and specific assays revealed that (R)-PMZ exhibited more pronounced adverse effects on larvae at the embryonic, morphological, and biochemical level than the racemate and (S)-PMZ. Toxicity and potential bioaccumulation of these compounds in daphniids and fish were also conducted using in silico tests through proprietary software. The results revealed a concordance between the experimental and predicted EC50 and LC50 values in both species.

Daphnia magna

Promethazine

Ecotoxicity

Danio

Brachionus

Ceriodaphnia dubia

10.1093/etojnl/vgae028

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Exploring New Fuels in the Global Energy Transition: A Focus on Brazil

Technical Papers ... Rio Oil & Gas (2024)

Ana Rita Carvalho Carlos H. M. de Lima Carlos Ribeiro Marcelo Afonso Ribeiro Julia Vianna Hannig da Gama

Energy transition

10.48072/2525-7579.roge.2024.4349

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Sublethal ecotoxicity assays of an emergent psychoactive substance in Daphnia magna

RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia (2022)

Ariana Pérez‐Pereira Ana Rita Carvalho Bruno B. Castro João Soares Carrola Carla Fernandes

Results: Poisoning has been reported as cause of admission and death in Portuguese rescue centres in both mammals and birds [3,4].Strychnine, insecticides, anticoagulants rodenticides, molluscicides, heavy metals have all been reported in wildlife poisoning events in Portugal.Clinical cases of accidental and intentional poisoning have been reported in carnivorous mammals and birds of prey (4,5).Iberian wolfs, Iberian lynxes, red foxes, vultures, kites, eagles and rooks are among the most frequently reported species.Stomach contents, blood, urine, liver and kidneys are the most used samples to detect these substances and perform the forensic diagnosis [1,5].Conclusions: Poisoning may represent a threat to some Portuguese fauna, since some of the affected species are endangered and essential to the ecosystem stability.New regulations, monitoring programs and better resources are crucial to quickly intervene in suspicious cases in rehabilitation centres; and minimize the impact of this threat to wild species.

Daphnia magna

Ecotoxicity

10.51126/revsalus.v4isup.284

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O PAPEL DO SERVIÇO SOCIAL E DA DIREÇÃO TÉCNICA NA AVALIAÇÃO DOS RISCOS PSICOSSOCIAIS NAS AJUDANTES DE AÇÃO DIRETA DE UMA ESTRUTURA RESIDENCIAL PARA PESSOAS IDOSAS

Deleted Journal (2021)

Joana Brinca Nídia Menezes Ana Branca Carvalho Ricardo Ferreira de Almeida Estefânia Ribeiro

As Estruturas Residenciais para Pessoas Idosos (ERPI), acolhem um publico cada vez mais heterogeneo em termos sociais, familiares e culturais o que implica que as pessoas que cuidam de idosos detenham de competencias que vao alem da formacao profissional. Paralelamente a isto, diversos estudos sugerem que as pessoas que diretamente estao envolvidas no cuidado ao idoso sofrem de elevados indices de depressao e ansiedade, Estresse e Burnout (Goodhead & McDonald, 2007; Ozcakar et. al., 2012) menor satisfacao com a vida e sensacao de estar sobrecarregado, sobretudo quando o tempo gasto na prestacao de cuidados aumenta (Goodhead & McDonald, 2007). De acordo com Vaz e Serra (2011) estao descritas na literatura (Leka et al., 2008) inumeras estrategias e instrumentos que, se utilizados de forma continua e numa logica de reflexividade concorrem para uma pratica orientada para a etica que nao comprometa, a saude psicossocial nem a seguranca ocupacional. O que implica uma mudanca nao apenas individual, mas tambem social, e institucional tendo o Assistente Social um papel decisivo a este nivel, dadas as suas competencias tecnicas operativas, etico relacionais e cientificas. Neste âmbito e a fim de identificar e avaliar os riscos psicossociais das Ajudantes de Acao Direta da Estrutura Residencial para Pessoas Idosas da Santa Casa da Misericordia de Moimenta da Beira, foi aplicado um inquerito por questionario a vinte Ajudantes de Acao Direta, composto por vinte e sete perguntas, distribuidas por cinco areas distintas, nomeadamente, dados sociodemograficos; horarios e turnos de trabalho; trabalho, participacao e tomada de decisoes; trabalho e ambiente socio emocional, e por fim, a natureza do trabalho e satisfacao. Atraves da analise dos resultados obtidos foi possivel identificar os riscos psicossociais existentes, bem como propor estrategias de intervencao para suprir os riscos, principalmente nas categorias “Exigencias Emocionais”, “Gestao e Organizacao no Trabalho” e “Recursos Humanos”.

10.46691/es.v0i0.363

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Integrated Approach for Synthetic Cathinone Drug Prioritization and Risk Assessment: In Silico Approach and Sub-Chronic Studies in Daphnia magna and Tetrahymena thermophila

Molecules (2023)

Ariana Pérez‐Pereira Ana Rita Carvalho João Soares Carrola Maria Elizabeth Tiritan Cláudia Ribeiro

Synthetic cathinones (SC) are drugs of abuse that have been reported in wastewaters and rivers raising concern about potential hazards to non-target organisms. In this work, 44 SC were selected for in silico studies, and a group of five emerging SC was prioritized for further in vivo ecotoxicity studies: buphedrone (BPD), 3,4-dimethylmethcathinone (3,4-DMMC), butylone (BTL), 3-methylmethcathinone (3-MMC), and 3,4-methylenedioxypyrovalerone (MDPV). In vivo short-term exposures were performed with the protozoan

Daphnia magna

Ecotoxicity

10.3390/molecules28072899

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Citations (5)