Qiuju Han

Shandong University

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Zhigang Tian

Henan Agricultural University

Cai Zhang

Shandong University

Jian Zhang

Southern Medical University

Jian Zhang

Shandong University

Peixiang Lan

Tongji Hospital

Huajun Zhao

Zhejiang Chinese Medical University

Qie Guo

Qingdao University

Cai Zhang

Tongji Hospital

Zhaohua Hou

Northwestern Polytechnical University

Zhaoyi Pan

Shandong University

Cooperative Institutions

Shandong University

118

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

Nankai University

Shandong First Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Sichuan University

University of Science and Technology of China

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Zero-Dimensional Te4+-Doped (Nh4)2sncl6 Crystals for Wled and Non-Contact Thermometry Applications

Jing Zhang Hongbo Qi Jing Li Hailong Yu Jing Zhou

Zero (linguistics)

10.2139/ssrn.5109443

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Citations (0)

New progress in prevention of pressure ulcers for patients undergoing prone ventilation patients

The Journal of practical nursing (2018)

Lei Song FU Yan-mei Miao Tuo Shanshan Liu Qiuju Han

As an important means of lung protective strategy, prone position ventilation (PPV) which can effectively shorten the time of mechanical ventilation, significantly reduce the mortality of patients with acute respiratory distress syndrome (ARDS), and is suitable for popularization and application in the ICU. However, some studies show that prolonged prone position can significantly increase the incidence of Stress injury, making it difficult to implement PPV in the practical level. In order to achieve the goal of safe and effective prevention of skin Stress injury, and to promote the correct implementation of PPV, this paper review the methods of preventing Stress injury in patients with PPV. Key words: Nursing care; Prone position ventilation; Pressure ulcers

Prone position

10.3760/cma.j.issn.1672-7088.2018.15.019

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Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs

International Immunopharmacology (2013)

Jing Qu Zhaohua Hou Qiuju Han Cai Zhang Zhigang Tian

10.1016/j.intimp.2013.08.013

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Citations (39)

Supplementary Figure 3 from Immunotherapy for Hepatoma Using a Dual-Function Vector with Both Immunostimulatory and Pim-3–Silencing Effects

Qie Guo Peixiang Lan Xin Yu Qiuju Han Jian Zhang

<p>PDF - 135K, Figure S3. Treatment with bi-functional vector promotes lymphocyte infiltration and tumor necrosis in tumor tissues. A. Tumor tissues were analyzed by H&E staining. The yellow arrows show lymphocyte infiltration, and the white arrows show necrosis in tumor tissues. Magnification: x 200. B. Tumor apoptosis was analyzed by TUNEL staining. C. Serum levels of IFN-alpha and IFN-beta after treatment were detected by ELISA.</p>

Infiltration (HVAC)

10.1158/1535-7163.22499668.v1

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Supplementary Figure 1 from Immunotherapy for Hepatoma Using a Dual-Function Vector with Both Immunostimulatory and Pim-3–Silencing Effects

Qie Guo Peixiang Lan Xin Yu Qiuju Han Jian Zhang

<p>PDF - 44K, Figure S1. The expression of Pim-3 in mouse hepatoma cell lines and human hepatocellular carcinoma tissues. The expression of Pim-3 in murine hepatoma cell lines H22 and Hepa1-6 and the normal liver cell line BNL.CL2 as measured by semi-quantitative RT-PCR (A) and Western blotting (B). The expression of Pim-3 in human hepatocellular carcinoma tissues (T) and nontumor tissues (N) detected by real-time PCR (C) and Western blotting (D).</p>

Hepatic carcinoma

Cloning (programming)

10.1158/1535-7163.22499674.v1

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STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients

Journal of Leukocyte Biology (2019)

Bingqing Zheng Yinli Yang Qiuju Han Chunlai Yin Zhaoyi Pan

Abstract NK cells play an important role in early control of HBV infection. The function of NK cells is inhibited in chronic hepatitis B virus (CHB) infection, although the underlying mechanism remains unknown. We found that the expression of STAT3 decreased in peripheral NK cells of CHB patients, and was associated with low levels of degranulation and IFN-γ secretion. In addition, STAT3 levels were positively correlated with cytolysis-associated molecules and antiviral cytokines, such as CD107a, granzyme B, perforin, and IFN-γ. HBsAg directly inhibited the expression and activation of STAT3 in NK cells, and knocking down STAT3 expression in NK cells inhibited proliferation, decreased cyclin d1 levels, and suppressed responsiveness to IL-21 stimulation. Furthermore, STAT3 directly bound to the promoter of NKp46, an important activating receptor of NK cells, to regulate its transcription and expression. Taken together, our findings indicate that STAT3 is an important positive regulator of NK cells, and provide a new mechanism of NK cell dysfunction in CHB.

Granzyme

10.1002/jlb.2a1118-421r

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TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth

OncoImmunology (2022)

Can-Can Zhao Qiuju Han Hao-Yan Ying Xiang-Xiang Gu Na Yang

Macrophages of the M2 phenotype in malignant tumors significantly aid tumor progression and metastasis, as opposed to the M1 phenotype that exhibits anti-cancer characteristics. Raising the ratio of M1/M2 is thus a promising strategy to ameliorate the tumor immunomicroenvironment toward cancer inhibition. We report here that tumor necrosis factor superfamily-15 (TNFSF15), a cytokine with anti-angiogenic activities, is able to facilitate the differentiation and polarization of macrophages toward M1 phenotype. We found that tumors formed in mice by Lewis lung carcinoma (LLC) cells artificially overexpressing TNFSF15 exhibited retarded growth. The tumors displayed a greater percentage of M1 macrophages than those formed by mock-transfected LLC cells. Treatment of mouse macrophage RAW264.7 cells with recombinant TNFSF15 led to augmentation of the phagocytic and pro-apoptotic capacity of the macrophages against cancer cells. Mechanistically, TNFSF15 activated STAT1/3 in bone marrow cells and MAPK, Akt and STAT1/3 in naive macrophages. Additionally, TNFSF15 activated STAT1/3 but inactivated STAT6 in M2 macrophages. Modulations of these signals gave rise to a reposition of macrophage phenotypes toward M1. The ability of TNFSF15 to promote macrophage differentiation and polarization toward M1 suggests that this unique cytokine may have a utility in the reconstruction of the immunomicroenvironment in favor of tumor suppression.

Macrophage polarization

M2 Macrophage

Lewis lung carcinoma

STAT1

10.1080/2162402x.2022.2032918

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Citations (30)

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

Journal of Hepatology (2016)

Xin Yu Peixiang Lan Xuben Hou Qiuju Han Nan Lü

10.1016/j.jhep.2016.12.018

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Citations (274)

Innate and adaptive immune escape mechanisms of hepatitis B virus

World Journal of Gastroenterology (2022)

Huajun Zhao Yifei Hu Qiuju Han Jian Zhang

Chronic hepatitis B virus (HBV) infection is an international health problem with extremely high mortality and morbidity rates. Although current clinical chronic hepatitis B (CHB) treatment strategies can partly inhibit and eliminate HBV, viral breakthrough may result due to non-adherence to treatment, the emergence of viral resistance, and a long treatment cycle. Persistent CHB infection arises as a consequence of complex interactions between the virus and the host innate and adaptive immune systems. Therefore, understanding the immune escape mechanisms involved in persistent HBV infection is important for designing novel CHB treatment strategies to clear HBV and achieve long-lasting immune control. This review details the immunological and biological characteristics and escape mechanisms of HBV and the novel immune-based therapies that are currently used for treating HBV.

Hepatitis B

Chronic infection

10.3748/wjg.v28.i9.881

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Citations (25)

Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance

Hepatology (2013)

Peixiang Lan Cai Zhang Qiuju Han Jian Zhang Zhigang Tian

Abstract Hepatitis B virus (HBV) persistence aggravates hepatic immunotolerance, leading to the failure of cell-intrinsic type I interferon and antiviral response, but whether and how HBV-induced hepatocyte-intrinsic tolerance influences systemic adaptive immunity has never been reported, which is becoming the major obstacle for chronic HBV therapy. In this study, an HBV-persistent mouse, established by hydrodynamic injection of an HBV-genome-containing plasmid, exhibited not only hepatocyte-intrinsic but also systemic immunotolerance to HBV rechallenge. HBV-specific CD8 + T-cell and anti-HBs antibody generation were systemically impaired by HBV persistence in hepatocytes. Interestingly, HBV-induced hepatocyte-intrinsic immune tolerance was reversed when a dually functional vector containing both an immunostimulating single-stranded RNA (ssRNA) and an HBx-silencing short hairpin RNA (shRNA) was administered, and the systemic anti-HBV adaptive immune responses, including CD8 + T-cell and anti-HBs antibody responses, were efficiently recovered. During this process, CD8 + T cells and interferon-gamma (IFN-γ) secreted play a critical role in clearance of HBV. However, when IFN-α/β receptor was blocked or the Toll-like receptor (TLR)7 signaling pathway was inhibited, the activation of CD8 + T cells and clearance of HBV was significantly impaired. Conclusion : These results suggest that recovery of HBV-impaired hepatocyte-intrinsic innate immunity by the dually functional vector might overcome systemic adaptive immunotolerance in an IFN-α- and TLR7-dependent manner. The strategy holds promise for therapeutic intervention of chronic persistent virus infection and associated cancers. (Hepatology 2013;)

Systemic administration

10.1002/hep.26339

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Citations (56)