Bruno Deltreggia Benites

Universidade Estadual de Campinas (UNICAMP)

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Sara Teresinha Olalla Saad

Universidade Estadual de Campinas (UNICAMP)

Fernando Ferreira Costa

Universidade Estadual de Campinas (UNICAMP)

Marcelo Addas‐Carvalho

Universidade Estadual de Campinas (UNICAMP)

Simone Cristina Olenscki Gilli

Universidade Estadual de Campinas (UNICAMP)

Paula de Melo Campos

Universidade Estadual de Campinas (UNICAMP)

Adriana da Silva Santos Duarte

Universidade Estadual de Campinas (UNICAMP)

José Luiz Proença-Módena

Universidade Estadual de Campinas (UNICAMP)

Fernando Vieira Pericole

Universidade Estadual de Campinas (UNICAMP)

Audrey Basso Zangirolami

Universidade Estadual de Campinas (UNICAMP)

Fabiana Granja

Universidade Estadual de Campinas (UNICAMP)

Cooperative Institutions

Universidade Estadual de Campinas (UNICAMP)

181

Universidade de São Paulo

Hospital de Clínicas da Unicamp

University of Oxford

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Imperial College London

Fundação Oswaldo Cruz

Universidade Federal de Roraima

Universidade Federal do Rio de Janeiro

Universidade São Francisco

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Echocardiografic Abnormalities in Patients with Sickle Cell/β-Thalassemia Do Not Depend on the β-Thalassemia Phenotype

Blood (2017)

Bruno Deltreggia Benites Ianara Silva Cisneiros Stéphany Oliveira Bastos Ana Paula Beppler Lazaro Lino Fernando Ferreira Costa

Acute chest syndrome

Hemoglobinopathy

Hemoglobin electrophoresis

Transferrin saturation

Beta thalassemia

Priapism

10.1182/blood.v130.suppl_1.987.987

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Citations (0)

Zika virus intrusion into the blood supply: Concerns about transfusion safety

Elsevier eBooks (2021)

Bruno Deltreggia Benites Marcelo Addas‐Carvalho

Zika Virus

Declaration

Blood supply

10.1016/b978-0-12-820268-5.00043-2

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N-GAL na avaliação do perfil de alterações renais em pacientes com síndromes falciformes

Revista dos Trabalhos de Iniciação Científica da UNICAMP (2019)

Paolla Ravida Alves de Macedo Simone Cristina Olenscki Gilli Sara Teresinha Olalla Saad Fernanda Andrade Orsi Célia Regina Garlipp

O envolvimento renal na doença falciforme compreende uma gama de desordens glomerulares e tubulares sendo sua incidência diretamente proporcional ao aumento da sobrevida dessa população sendo importante causador de morbidade e mortalidade desses pacientes. Os distúrbios renais nas doenças falciformes podem apresentar-se de forma assintomática, ou através de sinais como hematúria. Envolvidos na fisiopatologia desses eventos estão diversos mecanismos, como alterações na concentração e acidificação urinárias, microtromboses e infarto renal. A isquemia medular pode levar a inabilidade em manter o gradiente de íon hidrogênio, levando a uma forma incompleta de acidose tubular renal distal (tipo IV), que pode estar associada a hipercalemia independente da aldosterona. Há escassez de dados na literatura avaliando hipercalemia e acidose tubular renal especificamente em pacientes portadores de síndromes falciformes. Pouco se sabe também sobre a melhor maneira de avaliar a função renal nesse grupo de pacientes, cuja doença é caracterizada, nos estágios iniciais, por hiperfluxo glomerular, levando a falsas estimativas do real acometimento da função dos rins. Há escassez de dados na literatura avaliando hipercalemia e acidose tubular renal especificamente em pacientes portadores de síndromes falciformes. O objetivo deste estudo é fazer esse diagnóstico, e analisar a eficiência do N-GAL(Neutrophil Gelatinase Associated Lipocalin) para este diagnóstico.

10.20396/revpibic2620181112

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Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management

Hematology Transfusion and Cell Therapy (2024)

Bruno Deltreggia Benites Flávia Mendes Leite Selma Soriano Roberto Luiz da Silva Susankerle de Oliveira Costa Alves

Managing anemia before surgery is extremely important as it is a clinical condition that can significantly increase surgical risk and affect patient outcomes. Anemia is characterized by a reduction in the number of red blood cells or hemoglobin levels leading to a lower oxygen-carrying capacity of the blood. Proper treatment requires a multifaceted approach to ensure patients are in the best possible condition for surgery and to minimize potential complications. The challenge is recognizing anemia early and implementing a timely intervention to correct it. Anemic patients are more susceptible to surgical complications such as increased infection rates, slower wound healing and increased risk of cardiovascular events during and after surgery. Additionally, anemia can exacerbate existing medical conditions, causing greater strain on organs and organ systems. To correct anemia and optimize patient outcomes, several essential measures must be taken with the most common being identifying and correcting iron deficiency.

Hemotherapy

Blood management

Hematology

10.1016/j.htct.2024.02.006

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PROGRESSIVE COGNITIVE DECLINE IN ADULTS WITH SICKLE CELL DISEASE (SCD): THE EFFECTS OF THE SOCIOCULTURAL BACKGROUND AND CEREBRAL ATROPHY

Hematology Transfusion and Cell Therapy (2020)

Bruno Deltreggia Benites C.M. Silva Brunno Machado de Campos P.M. Campos Samuel Souza Medina

Cerebral atrophy

10.1016/j.htct.2020.10.086

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Increased expression of APAF‐1 in low‐risk myelodysplastic syndrome: a possible role in the pathophysiology of myelodysplasia

European Journal Of Haematology (2010)

Bruno Deltreggia Benites Fabı́ola Traina Adriana da Silva Santos Duarte Irene Lorand‐Metze Fernando Ferreira Costa

APAF-1 is a central component of the intrinsic pathway of apoptosis, where APAF-1 dysregulation results in the development of diverse human neoplasms. The aim of this study was to characterize the mRNA expression levels of APAF-1 transcripts in low-risk and high-risk MDS and to elucidate whether the expression levels of APAF-1 transcripts are modulated with increased apoptosis in CD34(+) MDS cells undergoing erythroid differentiation.APAF-1 (NM_181861) expression was verified, by quantitative RT-PCR, in bone marrow aspirates from 33 patients with myelodysplastic syndromes (MDS), at the time of diagnosis, and in erythroid differentiation cultures from CD34(+) from normal donors and patients with MDS.APAF-1 expression was significantly higher in low-risk, compared to high-risk MDS, according to IPSS (P < 0.0001), FAB (P = 0.0265), and cytogenetic risk (P = 0.0134). Low-risk MDS-derived differentiated erythroid cells demonstrated an increased expression of APAF-1, compared with normal cells, accompanied by an augmented rate of apoptosis.Increased expression of APAF-1 in low-risk disease and its positive correlation with the apoptotic rate observed during the erythroblast differentiation of low-risk MDS cells may indicate that the modulation of APAF-1, at the transcriptional level, participates in the pathophysiology of MDS.

Pathophysiology

10.1111/j.1600-0609.2010.01429.x

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Citations (5)

Acupuncture as a Complementary Treatment for Leg Ulcers in Sickle-Cell Disease

Medical Acupuncture (2023)

Bruno Deltreggia Benites Heloise Ciol Sara Teresinha Olalla Saad Rogerio Oliva Suguitani

Background: Sickle-cell diseases (SCD) are a group of hereditary disorders in which a specific mutation in the gene that encodes the hemoglobin ß chain leads to formation of an anomalous hemoglobin molecule (HbS) with high polymerization power. This leads to sickling of erythrocytes in situations of low oxygen tension, such as in microcirculation, resulting in peripheral microvasculature occlusion, chronic hemolysis, inflammation, and damage to several target organs. Malleolar ulcers are among the most-debilitating complications of the disease, as they are associated with significant pain, secondary infections, and social impact due to their aesthetic impairment. There are no completely satisfactory therapeutic options for this complication; local healing agents, antibiotics, and dressings are used, with high rates of recurrence and complications, such as osteomyelitis and even limb amputation. Case: This case study evaluated the effect of Traditional Chinese Medicine techniques on chronic malleolar ulcers in a 49-year-old male patient. Ten sessions of systemic acupuncture (combinations involving Source, Master, Energetic Action, and Extraordinary Vessels points), auriculotherapy, and dressing with magnets were conducted. Results: Although the primary outcome sought was not reached (decrease in ulcer diameters), this patient had great reduction of local pain, a decrease in limb edema, and important reduction of his inflammatory condition, reflected in his decreasing blood levels of C-reactive protein. Conclusions: These results show that acupuncture should be considered as an important auxiliary treatment for SCD complications.

10.1089/acu.2023.0046

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Cytokine polymorphisms in sickle cell disease and the relationship with cytokine expression

Experimental Hematology (2016)

Simone Cristina Olenscki Gilli Fernando Vieira Pericole Bruno Deltreggia Benites Emília Sippert Lilian Castilho

10.1016/j.exphem.2016.03.008

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Citations (20)

Sickle cell/β-thalassemia: Comparison of Sβ⁰ and Sβ⁺ Brazilian patients followed at a single institution

Hematology (2016)

Bruno Deltreggia Benites Stéphany Oliveira Bastos Gabriel Baldanzi Allan O. Santos Celso Darío Ramos

In sickle cell/β-thalassemia, mutations in the corresponding β-globin genes are responsible for complex pathological events resulting in diverse clinical complications. The objective of this study was to provide an overview of the clinical and laboratory characteristics of patients with the syndrome, and of the degree of severity of clinical manifestations resulting from the β-thalassemia mutation.A retrospective chart review was performed on 46 patients with sickle cell/β-thalassemia (31 Sβ° and 15 Sβ+), evaluating hematological parameters and end organ damage. Statistical analyzes were carried out in order to highlight differences between the two groups according to the nature of the thalassemia mutation.As expected, patients with the Sβ0 phenotype had a higher degree of hematological involvement in comparison to Sβ+ patients; with lower hemoglobin levels, and signs of more intense chronic hemolysis. However, Sβ+ patients were more prone to the occurrence of acute chest syndrome. The impact of the thalassemia mutation upon total body and bone composition was also evident, as Sβ0 patients presented lower body mass index (BMI) and bone mineral density. The degree of bone damage correlated to lower BMI and hemoglobin levels, as well as plaquetosis, monocytosis and elevated lactate dehydrogenase, possibly reflecting the effects of hemolysis and inflammation upon bone metabolism and body constitution.This study identified significant differences among sickle cell/β-thalassemia patients according to the beta mutation involvement, pointing to an important predictor of disease severity.

Beta thalassemia

Hemoglobinopathy

10.1080/10245332.2016.1187843

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Citations (14)

MDR-1 and GST polymorphisms are involved in myelodysplasia progression

Leukemia Research (2013)

Bruna Palodetto Paula de Melo Campos Bruno Deltreggia Benites Elvira Deolinda Rodrigues Pereira Velloso Fabı́ola Traina

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by abnormal hematopoietic differentiation and maturation, which progress toward acute leukemia in approximately 30% of the cases. Drug metabolism polymorphisms in Cytochrome P450 2B6 (CYP2B6), Glutathione S-transferase (GST) and Dehydrogenase Quinone 1 (NQO1) enzymes and P-glycoprotein (MDR-1) could modify enzyme activity. Thus, the aim of this study was to identify the influence of CYP2B6 G15631T, GSTT1, GSTM1, NQO1 C609T and MDR-1 C3435T polymorphisms on MDS progression. We analyzed 78 MDS patients using the PCR-RFLP and multiplex method. The frequency of GST deletions and MDR-1 CC genotype was lower in progression-free patients compared to patients with progression; GST: 17% vs. 35% (P=0.018); MDR-1 gene: 19% vs. 48% (P=0.012). We also verified the influence of GST deletions and MDR-1 C3435T on patient overall survival and found no significant difference (RR=0.75; P=0.599 and RR=0.79; P=0.594 respectively). We concluded that GSTM1 deletion may contribute toward MDS progression probably due to toxic metabolite accumulation which generates cell toxicity and DNA damage. Moreover, MDR-1 C3435T may have a protective effect against MDS progression because the expected lower expression of P-glycoprotein would lead to a higher degree of cell death. To the best of our knowledge, this is the first study showing the relationship of these polymorphisms with MDS progression.

Tumor progression

CYP2B6

10.1016/j.leukres.2013.04.024

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Citations (9)