Jessica Johnston

Mayo Clinic

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Endre Kiss-Tóth

University of Sheffield

Sheila E. Francis

University of Sheffield

Heather L. Wilson

University of Sheffield

Adrienn Angyal

University of Sheffield

Robert C. Bauer

Columbia University

Alison H. Goodall

Glenfield Hospital

Stephen E. Hamby

Glenfield Hospital

Daniel J. Rader

University of Pennsylvania

Carol C. Shoulders

Queen Mary University of London

Mark P. Ariaans

University of Sheffield

Cooperative Institutions

University of Sheffield

University of Pennsylvania

Chinese Academy of Medical Sciences & Peking Union Medical College

Royal Hallamshire Hospital

Commonwealth Scientific and Industrial Research Organisation

Mayo Clinic

Insigneo

California University of Pennsylvania

Imperial College London

Medical Research Council

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P14 MYELOID TRIB1 PROMOTES EXPERIMENTAL ATHEROSCLEROSIS

Cardiovascular Research (2018)

Jessica Johnston Adrienn Angyal Robert C. Bauer Stephen E. Hamby S K Suvarna

10.1093/cvr/cvy216.017

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Citations (1)

Recent refinements to cranial implants for rhesus macaques (Macaca mulatta)

Lab Animal (2016)

Jessica Johnston Yale E. Cohen Harry Shirley Joji Tsunada Sharath Bennur

Brain implant

10.1038/laban.997

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Citations (35)

Relationship between feminist identity and self-sexualizing attitudes and behaviors

PsycEXTRA Dataset (2014)

Samantha D. Christopher Esther N. Schwartz Jessica Johnston

10.1037/e537032014-001

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Citations (0)

Tribbles-1 Expression and Its Function to Control Inflammatory Cytokines, Including Interleukin-8 Levels are Regulated by miRNAs in Macrophages and Prostate Cancer Cells

Frontiers in Immunology (2020)

Chiara Niespolo Jessica Johnston Sumeet Deshmukh Swapna Satam Ziyanda Shologu

The pseudokinase TRIB1 controls cell function in a range of contexts, by regulating MAP kinase activation and mediating protein degradation via the COP1 ubiquitin ligase. TRIB1 regulates polarization of macrophages and dysregulated Trib1 expression in murine models has been shown to alter atherosclerosis burden and adipose homeostasis. Recently, TRIB1 has also been implicated in the pathogenesis of prostate cancer, where it is often overexpressed, even in the absence of genetic amplification. Well described TRIB1 effectors include MAP kinases and C/EBP transcription factors, both in immune cells and in carcinogenesis. However, the mechanisms that regulate TRIB1 itself remain elusive. Here, we show that the long and conserved 3’untranslated region (3’UTR) of TRIB1 is targeted by miRNAs in macrophage and prostate cancer models. By using a systematic in silico analysis, we identified multiple “high confidence” miRNAs potentially binding to the 3’UTR of TRIB1 and report that miR-101-3p and miR-132-3p are direct regulators of TRIB1 expression and function. Binding of miR-101-3p and miR-132-3p to the 3’UTR of TRIB1 mRNA leads to an increased transcription and secretion of interleukin-8. Our data demonstrate that modulation of TRIB1 by miRNAs alters the inflammatory profile of both human macrophages and prostate cancer cells.

Macrophage polarization

10.3389/fimmu.2020.574046

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Citations (22)

Collagenoma in an African Clawed Frog (Xenopus laevis).

PubMed (2016)

Jessica Johnston Blythe H Philips Anthony J Carty Peter S. Klein Alexis Brice

A 3-y-old female Xenopus laevis was reported for a gray mass on the abdomen. The frog was used for egg collection and was otherwise experimentally naïve. On physical exam, the frog was bright and active and had a firm, gray, lobulated mass (1.5 cm × 0.5 cm × 0.5 cm) in the cutaneous tissue of the left lateral abdomen. An excisional biopsy was performed under anesthesia, and the entire mass was removed and processed for histopathology. Microscopically, the dermis was greatly expanded by connective tissue with a marked decrease in the number of glands, and occasional degenerative glands were present. When stained with Masson trichrome, the excessive connective tissue stained blue, indicating that it was composed of collagen. With Verhoeff-van Gieson staining, the connective tissue stained bright red with an absence of black-staining material, demonstrating the presence of collagen and ruling out elastic fibers. In light of the morphology of the mass and the results of the special stains, the mass was diagnosed as a collagenoma. To our knowledge, this report is the first description of a collagenoma in X. laevis.

Masson's trichrome stain

Histopathology

African clawed frog

Van Gieson's stain

Trichrome

Hemidesmosome

Collagen fibres

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Neurocysticercosis in a Rhesus Macaque (

PubMed (2016)

Jessica Johnston Cecilia Dyer Susan Madison‐Antenucci Kimberly Mergen Christin L Veeder

An 8-y-old, intact, male rhesus macaque (Macaca mulatta) was sedated to undergo MRI in preparation for the implantation of cranial hardware. During imaging, 9 focal lesions were noted in the brain and musculature of the head. The lesions were hyperechoic with hypoechoic rims. The animal was deemed inappropriate for neuroscience research, and euthanasia was elected. Gross examination revealed multiple round, thick-walled, fluid-filled cysts (diameter, approximately 0.5 cm) in multiple tissues: one each in the left caudal lung lobe, left masseter muscle, and the dura overlying the brain and 8 throughout the gray and white matter of the brain parenchyma. Formalin-fixed sections of cyst-containing brain were stained with hematoxylin and eosin. Microscopic examination and molecular analysis of the COX1 (COI) gene recognized the causative organism as Taenia solium at 99.04% identity.

Taenia solium

Rhesus macaque

Gross examination

Parenchyma

Neurocysticercosis

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Citations (3)

Tribbles in inflammation

Biochemical Society Transactions (2015)

Jessica Johnston Shaghayegh Basatvat Zabran Ilyas Sheila E. Francis Endre Kiss-Tóth

Inflammation is part of the physiological innate immune response to invading pathogens and tissue injury. However, unresolved inflammation leads to human disease. The tribbles (TRIB) family of pseudokinase proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) networks. This review summarizes our current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and in disease development.

10.1042/bst20150095

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Citations (25)

Organocatalytic Approach to α-Substitutedsyn-α,β-Diamino Acids

Synfacts (2008)

Jessica Johnston Anurag Singh

Amidinium salt 1 was found to be a highly active and enantioselective catalyst for the addition of α-alkyl α -nitroesters to N-Boc-imines. A bulky ester group turned out to be essential to obtain high diastereoselectivity due to a synergistic effect with the catalyst. Under mild conditions the products were obtained in moderate to good yields (59-88%) and good to excellent diastereo- and enantioselectivities (dr = 5:1 to >20:1, er = 97:3 to 99.5:0.5). The reason for the opposite and thus unexpected syn-diastereoselectivity of this reaction compared to related transformations (J. N. Johnston and co-workers J. Am. Chem. Soc. 2004, 126, 3418; J. Am. Chem. Soc. 2007, 129, 3466) is so far unknown.

10.1055/s-2008-1077820

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P16 HUMAN MACROPHAGE SUBSETS IN THE PATHOGENESIS OF CAROTID ATHEROSCLEROSIS

Cardiovascular Research (2018)

Klaudia Kocsy Rania Alqurashi Jessica Johnston Kajus Baidžajevas Arshad Majid

Pathogenesis

10.1093/cvr/cvy216.019

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Citations (2)

Emotion contagion during support interactions in dating relationships

PsycEXTRA Dataset (2006)

J. R. McCreary Michelle Jarrett Jessica Johnston Jessica Harlan Kimberly Kinnear

Emotional contagion

10.1037/e633962013-592

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Citations (0)