Maria Teresa Guagnano

University of Chieti-Pescara

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Francesco Cipollone

University of Chieti-Pescara

Damiano D’Ardes

University of Chieti-Pescara

Francesca Santilli

University of Chieti-Pescara

S Sensi

University of Chieti-Pescara

Ilaria Rossi

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Andrea Boccatonda

Policlinico S.Orsola-Malpighi

Giovanni Davı̀

University of Chieti-Pescara

Cosima Schiavone

University of Chieti-Pescara

Maria Rosaria Manigrasso

Ospedale SS. Annunziata

Marco Bucci

University of Padua

Cooperative Institutions

Policlinico S.Orsola-Malpighi

283

Azienda Ospedaliera Universitaria Senese

258

Ospedale San Paolo

256

IRCCS Ospedale San Raffaele

256

Azienda Ospedaliera Citta' della Salute e della Scienza di Torino

253

University of Chieti-Pescara

222

Istituti di Ricovero e Cura a Carattere Scientifico

220

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

205

University of Milan

187

University Orthopedics Center

115

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Associations between hypertriglyceridemia and serum ghrelin, adiponectin, and IL-18 levels in HIV-infected patients.

PubMed (2006)

Katia Falasca Maria Rosaria Manigrasso Delia Racciatti Pompea Zingariello Margherita D’Alessandro

HIV-related metabolic abnormalities include hypertriglyceridemia, hypercholesterolemia, insulin resistance, and diabetes mellitus. Recent studies suggest a role of ghrelin in promoting the deposition of triglycerides (TG) in the liver and regulating the metabolic action of adiponectin. Visceral fat is a key regulator of inflammation and it secretes proinflammatory cytokines (eg, interleukin-18, IL-18), with potential atherogenic activity. The aim of this study was to assay serum concentrations of ghrelin, adiponectin, and IL-18 in HIV+ patients, with and without hypertriglyceridemia, who were receiving highly active antiretroviral therapy (HAART). The 49 HIV+ patients were divided in 2 groups: 17 patients with serum TG concentration >200 mg/dl (group A) and 32 patients with normal serum TG concentration (group B). All subjects underwent viral and immunological evaluations and determinations of serum cholesterol, glucose, ghrelin, adiponectin, and IL-18. No differences of viral and immunological parameters were observed between the 2 groups. Serum levels of ghrelin were 768 +/- 596 pg/dl in group A and 470 +/- 248 pg/dl in group B (p = 0.01). Group A had lower serum adiponectin levels (8.4 +/- 3.6 microg/dl) than group B (18.2 +/- 10.1 microg/dl; p = 0.0001). Serum IL-18 levels were 455 +/- 199 pg/ml in group A and 258 +/- 233 pg/ml in group B (p = 0.005). The patients with hypertriglyceridemia showed a positive correlation between serum triglyceride and ghrelin levels (r = 0.51, p = 0.03). These findings suggest potential roles of ghrelin, adiponectin, and IL-18 in the pathogenesis of metabolic disorders in HIV-infected patients.

Proinflammatory cytokine

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Citations (26)

Morning Sudden Cardiac Death

International Journal of Immunopathology and Pharmacology (2000)

Maria Teresa Guagnano Giovanni Davı̀S Sensi

A circadian variation of cardiac function with peak in the early morning was documented about twenty years ago. A circadian rhythm of platelet aggregability, in the same time of the day, was demonstrated in healthy young male subjects. The morning hours were also reported as crucial for sympathetic nervous system activity, for heart rate variability, and for the abrupt rise in blood pressure. Altogether, these trigger factors may explain the high incidence of sudden cardiac death during the morning. In the primary prevention of sudden death in patients with high cardiovascular risk, many strategies were proposed, such as implantable cardioverter-defibrillators, antiarrhythmic and antihypertensive therapies, particularly beta-blockers and more recently, aspirin. Also in subjects without cardiovascular risk factors, it is predictable that early and continuous administration of low-dose aspirin, by inhibiting platelet aggregation and thrombin formation, particularly in morning hours, may represent an effective therapy for the prevention of myocardial infarction and morning sudden cardiac death.

Sudden Death

10.1177/039463200001300109

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Citations (6)

Effects of body composition on the procoagulant imbalance in obese patients

Journal of Thrombosis and Thrombolysis (2020)

Matteo Candeloro Marcello Di Nisio Emanuele Valeriani Raffaella Auciello Sara La Barba

10.1007/s11239-020-02287-1

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Citations (2)

Association of low-grade inflammation and platelet activation in patients with hypertension with microalbuminuria

Clinical Science (2008)

Patrizia Ferroni Maria Teresa Guagnano Angela Falco Vincenzo Paoletti Maria Rosaria Manigrasso

Increased levels of sCD40L (soluble CD40 ligand) have been associated with enhanced in vivo platelet activation, and may represent a molecular link between inflammation and a prothrombotic state. The aim of the present study was to analyse the relationship between platelet activation, endothelial dysfunction, low-grade inflammation and sCD40L in patients with hypertension with or without MA (microalbuminuria). A cross-sectional comparison of sCD40L levels was performed in 25 patients with MH (essential hypertension with MA) pair-matched for gender and age with 25 patients with EH (essential hypertension) and 25 HS (healthy subjects with normotension). Circulating levels of CRP (C-reactive protein), a marker of inflammation, sP-selectin (soluble P-selectin), a marker of in vivo platelet activation, and ADMA (asymmetric dimethylarginine) and vWF (von Willebrand factor), markers of endothelial dysfunction, were analysed in each subject. sCD40L levels were increased in patients with MH compared with either patients with EH (P<0.001) or HS (P<0.0001). A highly significant correlation between plasma sCD40L and sP-selectin (P<0.0001), vWF (P<0.001) or CRP levels (P<0.05) was observed in patients with MH. Multivariate regression analysis showed that sP-selectin was the strongest independent predictor of sCD40L levels (P<0.0001) in patients with MH. Patients with hypertension with both vWF and CRP levels above the median had the highest sCD40L levels (P<0.0001). Factorial ANOVA of all of the patients with hypertension confirmed that only patients with MH with low-grade inflammation had elevated levels of sCD40L. In conclusion, sCD40L levels appear to discriminate a subset of patients characterized by MA and low-grade inflammation, suggesting that inhibition of the CD40/CD40L system may represent a potential therapeutic target in subjects with hypertension at a high risk of cardiovascular events.

Endothelial Dysfunction

Microalbuminuria

Endothelial Activation

Essential hypertension

Asymmetric dimethylarginine

10.1042/cs20070307

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Citations (24)

Burnout among hospital staff during the COVID-19 pandemic: Longitudinal results from the international Cope-Corona survey study

Journal of Psychosomatic Research (2022)

Markus Müller Eva Baillés Jordi Blanch Xavier Torres Araceli Rousaud

Occupational Burnout

10.1016/j.jpsychores.2022.111102

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Citations (18)

Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry

Internal and Emergency Medicine (2020)

Christiano Argano Nicola Scichilone G Natoli Alessandro Nobili Gino Roberto Corazza

Depression

10.1007/s11739-020-02412-1

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Citations (22)

Association between plasma interleukin-18 levels and liver injury in chronic hepatitis C virus infection and non-alcoholic fatty liver disease.

PubMed (2005)

Jacopo Vecchiet Katia Falasca Pierluigi Cacciatore Pompea Zingariello Margherita D’Alessandro

There is significant upregulation of interleukin-18 (IL-18) expression in viral infectious diseases and in some chronic hepatic diseases, especially (i) hepatitis C virus (HCV) infection, (ii) HCV infection with persistently normal ALT levels (PNAL), and (iii) non-alcoholic fatty liver disease (NAFLD). The aim of this study was a better understanding of the implications of plasma IL-18 levels in the above-mentioned liver diseases. Thirty-four patients with HCV infection, 13 with NAFLD, and 10 controls were enrolled. The HCV-RNA and HCV-genotypes and the serum or plasma levels of IL-18, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (gamma-GT), alkaline phosphatase, total cholesterol, triglycerides, alpha(1)-fetoprotein, and ferritin were evaluated. Patients with HCV showed higher levels of IL-18 than the NAFLD patients (p <0.01) and the controls (p <0.005). Patients with NAFLD showed higher values of body mass index and liver disease parameters, compared to HCV-infected subjects or controls. These data confirm previous reports of enhanced expression of IL-18 in patients with HCV and NAFLD, compared to healthy subjects, and suggest that IL-18 is important as a marker of liver diseases.

Liver disease

Hepatitis C

Alanine aminotransferase

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Citations (49)

Pain and Frailty in Hospitalized Older Adults

Pain and Therapy (2020)

Ilaria Ardoino Carlotta Franchi Alessandro Nobili Pier Mannuccio Mannucci Oscar Corli

Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. In light of this knowledge gap, 3577 acutely hospitalized patients 65 years or older enrolled in the REPOSI register, an Italian network of internal medicine and geriatric hospital wards, were assessed to calculate the frailty index (FI). The impact of pain and some of its characteristics on the degree of frailty was evaluated using an ordinal logistic regression model after adjusting for age and gender. The prevalence of pain was 24.7%, and among patients with pain, 42.9% was regarded as chronic pain. Chronic pain was associated with severe frailty (OR = 1.69, 95% CI 1.38–2.07). Somatic pain (OR = 1.59, 95% CI 1.23–2.07) and widespread pain (OR = 1.60, 95% CI 0.93–2.78) were associated with frailty. Osteoarthritis was the most common cause of chronic pain, diagnosed in 157 patients (33.5%). Polymyalgia, rheumatoid arthritis and other musculoskeletal diseases causing chronic pain were associated with a lower degree of frailty than osteoarthritis (OR = 0.49, 95%CI 0.28–0.85). Chronic and somatic pain negatively affect the degree of frailty. The duration and type of pain, as well as the underlying diseases associated with chronic pain, should be evaluated to improve the hospital management of frail older people.

10.1007/s40122-020-00202-3

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Citations (29)

Platelet activation in obesity and metabolic syndrome

Obesity Reviews (2011)

Francesca Santilli Natale Vazzana Rossella Liani Maria Teresa Guagnano Giovanni Davı̀

Summary Obesity is associated with increased cardiovascular disease. Metabolic syndrome (MS) identifies substantial additional cardiovascular risk beyond the individual risk factors, and is a powerful predictor of cardiovascular events even regardless of body mass index, thus suggesting a common downstream pathway conferring increased cardiovascular risk. Platelet hyper‐reactivity/activation plays a central role to accelerate atherothrombosis and is the result of the interaction among the features clustering in obesity and MS: insulin resistance, inflammation, oxidative stress, endothelial dysfunction. Interestingly, the same pathogenic events largely account for the less‐than‐expected response to antiplatelet agents, namely low‐dose aspirin. The proposed explanations for this phenomenon, besides underdosing of drug and/or reduced bioavailability, subsequent to excess of adipose tissue, include enhanced platelet turnover, leading to unacetylated COX‐1 and COX‐2 in newly formed platelets as a source of aspirin‐escaping thromboxane formation; extraplatelet sources of thromboxane, driven by inflammatory triggers; and enhanced lipid peroxidation, activating platelets with a mechanism bypassing COX‐1 acetylation or limiting COX‐isozyme acetylation by aspirin. This review will address the complex interactions between platelets and the pathogenic events occurring in obesity and MS, trying to translate this body of mechanistic information into a clinically relevant read‐out, in order to establish novel strategies in the prevention/treatment of atherothrombosis.

10.1111/j.1467-789x.2011.00930.x

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Citations (219)

Association between Serum Leptin Levels and 24‐Hour Blood Pressure in Obese Women

Obesity Research (2003)

Maria Teresa Guagnano Maria Rosaria Manigrasso Enzo Ballone R. Della Vecchia Graziano Riccioni

Abstract Objective : To assess the relationship between serum leptin and 24‐hour blood pressure (BP) in obese women, according to body fat distribution. Research Methods and Procedures : A cross‐sectional study was carried out in a population of 70 nondiabetic, normotensive, obese women (40 with android and 30 with gynoid type of obesity) and 20 nonobese healthy women as a control group. All subjects underwent 24‐hour ambulatory BP monitoring. Blood samples were collected for serum leptin and plasma insulin measurements. Total cholesterol and high‐density lipoprotein cholesterol were also measured. Results : Serum leptin levels were significantly higher in obese subjects than in controls, and they were more elevated in android obese women than in gynoid ones. Leptin levels were positively related to body mass index (BMI), insulin, and waist and hip circumferences in the android group. Among gynoid subjects, leptin levels showed positive associations with BMI and insulin. In women with android obesity, strong positive correlations ( p < 0.001) were found between leptin levels and 24‐hour systolic BP (SBP), daytime SBP, nighttime SBP, 24‐hour diastolic BP (DBP), and daytime DBP. Multiple regression analyses, including age, insulin and leptin concentrations, BMI, and waist and hip circumferences on 24‐hour and daytime SBP and DBP, showed that only leptin levels contributed to the variability of BP. Conclusions : Our study shows that serum leptin levels are directly related to 24‐hour BP levels in normotensive women with android fat distribution, independently of BMI.

10.1038/oby.2003.77

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Citations (27)