Detection of small molecules such as phthalates is a persistent challenge in current point-of-care sensors technology for environmental applications. Here, owing to their porous crystalline lattice and tuneable molecular specificity,...
The present study deals with preparation of nanoformulations of epigallocatchin gallate (EGCG) alone and with piperine, and evaluation of in vivo cognitive effect on Swiss albino male mice. EGCG (25 mg) was nanoencapsulated into a biocompatible and biodegradable protein nanocarrier, zein and was also separately nanoencapsulated with piperine (5 mg), a bioenhancer. Anti-solvent precipitation method was used for formulation of EGCG loaded nanosuspension and EGCG-Piperine nanocomplex. EGCG loaded nanosuspension (25 mg kg−1) and EGCG-Piperine nanocomplex (25 mg kg−1) were administered per se to mice for 3 successive weeks. The behaviour models i.e. Elevated plus maze and Morris water maze were used for assessing the cognitive behaviour. The influence of various drug treatments on locomotor activity of mice was also studied. The mice were sacrificed on 21st day followed by estimation of brain acetylcholinesterase activity. The significant reversion in scopolamine-induced amnesia in mice was observed after administration of EGCG loaded nanosuspension (25 mg kg−1) and EGCG-Piperine nanocomplex (25 mg kg−1). A significant reduction in brain acetylcholinesterase level in mice was observed after the administration of physostigmine (0.1 mg kg−1), EGCG loaded nanosuspension (25 mg kg−1) and EGCG-Piperine nanocomplex (25 mg kg−1). The oral administration of EGCG loaded nanosuspension for three successive weeks significantly improved cognitive behaviour in mice; and piperine potentiated the cognitive effect of EGCG loaded nanosuspension. Further, EGCG loaded nanosuspension showed improved cognitive behaviour in mice probably through inhibition of brain acetylcholinesterase activity, and facilitation of cholinergic pathways.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Advances in semiconductive nanowires with novel electronic and optical properties contribute towards new detection methods and revolutionize the way of biosensing. Owing to the large amount of literature pertaining to nanowires (indium oxide, polymer, silicon, and gold), the consequent proposal highlights the research published to feature ultra-sensitive handy biosensors. The focus of this article is the effective evaluation of the outstanding scientific challenges in one-dimensional nanostructures (nanowires) towards innovative and exceptional prospects in designing and fabrication of excellent primary transducers/sensors.
Carbon nanotubes (CNTs) are attracting increasing research interest as promising adsorbents for harmful cations, anions, and other organic and inorganic impurities present in natural sources of water. This study examined the feasibility of removing Rhodamine B dye from aqueous solutions using multi walled carbon nanotubes (MWCNTs) synthesized by chemical vapor deposition (CVD) method. The effects of dye concentration, pH and contact time on adsorption of direct dye by CNTs were also evaluated. The study used the Langmuir and Temkin isotherms to describe equilibrium adsorption. Additionally, pseudo second-order model was adopted to evaluate experimental data and thereby elucidate the kinetic adsorption process. The adsorption percentage of dye increased as contact time increased. Conversely, the adsorption percentage of dye decreased as dye concentration increased. The pseudo second-order model best represented adsorption kinetics. The capacity of CNTs to adsorb Rhodamine B was 65-90% at different pH values.
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