Marina Anatolyevna Yevseyeva

Smolensk State Medical University

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ВА

В. А. Правдивцев

Smolensk State Medical University

D.V. Sosin

Smolensk State Medical University

Andrey Viktorovich Yevseyev

Omsk State Medical University

Petr Dmitriyevich Shabanov

Czech Academy of Sciences, Institute of Experimental Medicine

Edgar Andreyevich Parfenov

Academy of Medical Sciences

АВ

А. В. Евсеев

Smolensk State Medical University

Cooperative Institutions

Smolensk State Medical University

Ministry of Health of the Russian Federation

Omsk State Medical University

Czech Academy of Sciences, Institute of Experimental Medicine

University of Nigeria

Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus

Belarusian State Medical University

Academy of Medical Sciences

Russian Cancer Research Center NN Blokhin

Russian Academy of Sciences

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Influence of new antihypoxant πq1983 on mice conditioned reflexes

Reviews on Clinical Pharmacology and Drug Therapy (2013)

D.V. Sosin Andrey Viktorovich Yevseyev В. А. Правдивцев Marina Anatolyevna Yevseyeva Petr Dmitriyevich Shabanov

The dynamic of active avoidance reaction in consist of a defense conditioned reflex after intragastric administration of new selenium-containing metal-complex substances πQ1983 (100 mg/kg) possessing protective action during development of acute exogenous hypoxia in animal have been studied in experiments on mice. Timing data of the active avoidance reaction in experiments on formerly trained mice under action of this substance used in same doze were analyzed. It was established that substance πQ1983 blocks formation of conditioned reflex. In the group of trained mice antihypoxant πQ1983 increases a latent period of the avoidance reaction and decreases the avoidance time. All found effects provided by intragastric administration of the antihypoxant were short-term (15– 20 h) and reversible. The results were compared with effects of antihypoxant amthizole.

Conditioned reflex

10.17816/rcf11226-30

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HYPOTHERMIC EFFECT OF ANTIHYPOXANTS πQ1983 AND πQ2170

Reviews on Clinical Pharmacology and Drug Therapy (2012)

D.V. Sosin Andrey Viktorovich Yevseyev Edgar Andreyevich Parfenov В. А. Правдивцев Marina Anatolyevna Yevseyeva

In experiments on mice the influence of the new antihypoxants (selenium containing metal complex substances πQ1983, πQ2170) on rectal temperature level dynamic after parenteral and enteral introductions was studied. It is established that both substances perform clear dose-dependent hypothermic effect exceeding an action of the antihypoxant amthizole. Was supposed that substance πQ2170 has high acute toxicity affirmed by significant mice death-rate.

Rectal temperature

Enteral administration

10.17816/rcf10478-82

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Influence of substance πQ1983 on evoked potentials of somatosensory cortex during acute hypoxia development

Reviews on Clinical Pharmacology and Drug Therapy (2014)

D.V. Sosin Andrey Viktorovich Yevseyev В. А. Правдивцев Marina Anatolyevna Yevseyeva Petr Dmitriyevich Shabanov

The influence of selenium-containing metal-complex substance πQ1983 on somatosensory cortex bioelectrical activity has been studied on cats (n = 22) during development of acute hypoxia. The condition of acute hypoxia was performed by making of loop including an animal, an apparatus for artificial lung ventilation, and a reservoir for respiration with 5 liter volume. Evoked activities of neurons were provided by direct electrical current irritations applied to the radial nerve of right superior extremity. Couple needle-shaped electrodes were used for mean evoked potentials registration. 100 mg/kg of the substance πQ1983 was introduced in the stomach 180 min before experiment. Also on any steps of the experiments ECG was registered. Containing of oxygen and carbon dioxide were determined by method of gas analysis in air enabled for respiration. It have been established that the substance πQ1983 taking internally increases cortex neurons functional activity period more than triple during acute hypoxia, stabilizes myocardial electrical activity, and helps animals to sustain the action of critical oxygen and carbon dioxide concentrations. Finally, the substance πQ1983 may be related to the high effectively antihypoxants because it significantly rises the resistance of animals with high CNS organization level (cats) to the acute hypoxia even after introduction per os.

Hypoxia

Somatosensory evoked potential

Hypoxic hypoxia

10.17816/rcf12341-49

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Acute hypoxia influence on cardio-respiratory system and new possibilities of pharmacological prophylactics of hypoxia in experiment

Reviews on Clinical Pharmacology and Drug Therapy (2016)

А. В. Евсеев В. А. Правдивцев D.V. Sosin Marina Anatolyevna Yevseyeva

Cardiorespiratory system activities have been studied on rats in experiment after oral introduction of the new selenium-containing metal-complex substance πQ1983 in dose 100 mg/kg before and under action of acute hypercapnic hypoxia (AH + Hc). The substance was introduced 90 min. before (incubation period) placement of animals into hypoxic chambers with 1.0 L free volume. During each experiment as well as during AH+Hc an electrical activity of myocardium (ECG) and respiration curves called pneumobarogramm (PBG) were recorded simultaneously. It has been established that the substance πQ1983 made cardiodepressive effect and decreases parameters of lungs ventilation in animals. According to ECG and PBG dynamics, rats protected by the substance demonstrated a high resistance level to the aroused acute hypoxia with hypercapnia, that expressed by weakening of early reactions from cardiorespiratory system under hypercapnia action, and by twice longer life span of animals in hypoxic experiment.

Hypoxia

Respiratory minute volume

10.17816/rcf14137-45

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ECG of rat under action of new metal-complex antixypoxant πq1983 in acute hypoxia

Reviews on Clinical Pharmacology and Drug Therapy (2013)

D.V. Sosin В. А. Правдивцев Marina Anatolyevna Yevseyeva Andrey Viktorovich Yevseyev Petr Dmitriyevich Shabanov

Fine changes of electrical activities in rat myocardium were studied after oral introduction of new selenium-containing metal-complex substance πQ1983 in dose 100 mg/kg before and after an acute hypercapnichypoxia (AH + Hc) development. A substance for comparison — metabolic antihypoxant amthizole was used by same way and dose. The substances were introduced 90 min before (incubation period) placing of animals into hypoxic chambers with 1.0 L free volume. ECG was recorded continually during both an incubation period and a hypoxic experiment. It has been established that the inhibitory action of the substance πQ1983 on electrical activity of rat myocardium manifests itself like a significant bradycardia. According with ECG data, rats protected with substance πQ1983 show the resistance level to the AH + Hc higher than ones that intake the antihypoxant amthizole. It was proved by peculiarities of early myocardial hypercapnic reactions, parameters of lifespan, and length of so called relative wellbeing period.

Hypoxia

10.17816/rcf11245-51

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Study of antihypoxic activities of metal complex selenium containing substances after their parenteral and enteralintroductions

Reviews on Clinical Pharmacology and Drug Therapy (2012)

D.V. Sosin Andrey Viktorovich Yevseyev Edgar Andreyevich Parfenov В. А. Правдивцев Marina Anatolyevna Yevseyeva

In experiments on mice undergone to an acute hypercapnic hypoxia and an acute hypobaric hypoxia a screening of antihypoxants among new selenium containing metal complex substances was performed after their intra-abdominal and oral introductions. It was found that substances πQ1983 and πQ2170 on both models of hypoxia make the defensive effects surpassing actions well-known antihypoxants such as amthizole and bemythil. It was shown that antihypoxiс affects of studied substances depend on their caused hypothermia. For the first time the protective action of selenium containing metal complex compounds was demonstrated after their introduction per os.

Hypoxia

10.17816/rcf10328-34

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Citations (1)