Dieudonné Emmanuel Pegnyemb

Université de Yaoundé I

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Joséphine Ngo Mbing

Université de Yaoundé I

Olivier Placide Noté

Université de Yaoundé I

Alex de Théodore Atchadé

Université de Yaoundé I

Auguste Abouem À Zintchem

Université de Yaoundé I

Eutrophe Le Doux Kamto

Université de Yaoundé I

Joseph Thierry Ndongo

Université de Yaoundé I

Raphaël Ghogomu Tih

Université de Yaoundé I

Bernard Bodo

Institut de Chimie des Substances Naturelles

Dominique Serge Ngono Bikobo

Université de Yaoundé I

Christian G. Bochet

University of Fribourg

Cooperative Institutions

Université de Yaoundé I

100

Centre National de la Recherche Scientifique

Laboratoire de Chimie

Université de Dschang

Institut de Recherches Médicales et d’Etudes des Plantes Médicinales

Université de Strasbourg

Inserm

University of Karachi

Laboratoire d'Innovation Thérapeutique

University of Geneva

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Chemical Constituents, Ethnomedicinal Uses, Pharmacology, and Toxicity of Dysphania Ambrosioides (L.) Mosyakin & Clemants, Formerly Chenopodium Ambrosioides L.

The Natural Products Journal (2021)

Boniface Pone Kamdem Eutrophe Le Doux Kamto Hugues Kamdem Paumo Lebogang Katata‐Seru Dieudonné Emmanuel Pegnyemb

Background: Dysphania ambrosioides (L.) Mosyakin & Clemants is an aromatic herb native to South America but also distributed widely throughout Africa and Europe. This plant is traditionally used to treat various ailments including pain and swellings, flu, parasitic diseases and is used as an analgesic, antipyretic, and wound healing. Phytochemical analyses of D. ambrosioides revealed the presence of terpenoids, flavonoids, coumarins, fatty acids, and miscellaneous compounds, among others, which might be responsible for its modern pharmacological actions. Objective: The present work summarizes recent developments on phytochemistry, ethnomedicinal use, pharmacology, and toxicity of D. ambrosioides. A critical assessment of the literature information of D. ambrosioides is also presented. Methods: The available information on D. ambrosioides was collected through libraries and electronic databases [Scifinder, ACS, Scielo, Science direct, Pubmed (National Library of Medicine), Wiley, Springer, PROTA, Web of Science, Google Web, Yahoo search and Google scholar] from respective inception until January 2021. Results: More than 150 compounds, including terpenoids, flavonoids, coumarins, fatty acids, and miscellaneous compounds, etc., were identified from D. ambrosioides. D. ambrosioides exhibited a wide range of pharmacological activities, including antimalarial, anti-inflammatory, antiparasitic, anticancer, insecticidal, antigiardial, among others. Metal nanoparticles synthesized from D. ambrosioides extracts presented enhanced pharmacological activities as compared to the crude plant extracts counterparts. Conclusion: D. ambrosioides is a promising medicinal plant, however, more in vivo experiments, cytotoxicity tests, and mechanisms of actions of its extracts and compounds are recommended to transubstantiate the ethnomedicinal claims of this plant into scientific rationale-based information.

Phytochemical

Web of science

Phytochemistry

Terpene

10.2174/2210315511666210920144526

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Citations (0)

Two biflavonoids from Ouratea nigroviolacea

Phytochemistry (2006)

Joséphine Ngo Mbing Cécile Enguehard‐Gueiffier Alex de Théodore Atchadé H. Allouchi Joseph Gangoué‐Piéboji

Biflavonoids

Stigmasterol

10.1016/j.phytochem.2006.07.027

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Citations (14)

Antiplasmodial activities of indole alkaloids from Tabernaemontana penduliflora K. Schum (Apocynaceae)

Fitoterapia (2021)

André Néhémie Bitombo Auguste Abouem À Zintchem Alex de Théodore Atchadé Norbert Mbabi Nyemeck Dominique Serge Ngono Bikobo

Apocynaceae

Indole alkaloid

10.1016/j.fitote.2021.104941

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Citations (8)

Carbazole-, Aspidofractinine-, and Aspidocarpamine-Type Alkaloids from Pleiocarpa pycnantha

Journal of Natural Products (2018)

Joseph Thierry Ndongo Joséphine Ngo Mbing Aymeric Monteillier Michel Feussi Tala Michael Rütten

Three new alkaloids, janetinine (1a), pleiokomenine A (2), and huncaniterine B (3a), and 13 known compounds, pleiomutinine (3b), huncaniterine A (3c), 1-carbomethoxy-β-carboline (4), evoxanthine (5), deformyltalbotine acid lactone (6), pleiocarpamine (7), N4-methyl-10-hydroxygeissoschizol (8), spegatrine (9), neosarpagine (10), aspidofractinine (11), N1-methylkopsinin (12), pleiocarpine (13), and N1-methylkopsinin-N4-oxide (14), were isolated from the stem bark of Pleiocarpa pycnantha. Janetinine (1a) is a carbazole alkaloid; in pleiokomenine A (2), two aspidofractinine-type alkaloids are bridged by a methylene unit in an unprecedented way, and huncaniterine B (3a) is a pleiocarpamine–aspidofractinine-type dimer. The structures and relative configurations of these compounds were elucidated on the basis of NMR and MS analyses. Their absolute configurations were defined by means of experimental and calculated ECD data, and additionally, the structures of 5 and 13 were determined by single crystal X-ray diffraction. Compounds 1a, 2, 3b, 4, 6, 9, and 12 displayed cancer chemopreventive properties through either quinone reductase induction (CD = 30.7, 30.2, 29.9, 43.5, and 36.7 μM for 1a, 4, 6, 9, and 12, respectively) and/or NF-κB inhibition with IC50 values of 13.1, 8.4, 9.4, and 8.8 μM for 2, 3b, 6, and 12, respectively.

Carbazole

10.1021/acs.jnatprod.7b00958

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Citations (15)

Acylsteryl glycosides and other constituents from Campylospermum densiflorum (Ochnaceae)

HAL (Le Centre pour la Communication Scientifique Directe) (2011)

Dominique Ngono Bikobo Jeanne Louise Nkot Paul Mosset Alex de Théodore Atchadé Joseph Thierry Ndongo

A mixture of two new acylsteryl glycosides named densifloside A and B was isolated from the leaves of Campylospermum densiflorum , together with serotobenine, decursivine, N-feruloyltriptamine , ent -16 �,17dihydroxykauran-19-oic acid, menisdaurin, and secoisolariciresinol. The structure elucidations were based on spectroscopic evidence. The biological assay of crude extract of this plant showed good antimicrobial activity against Gram-positive cocci, weak activity against Gram-negative bacilli , and displayed moderate activity against two strains of fungi ( C. albicans and C. neoformans ) among several strains.

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Flavonoids of Ochna afzelii.

ChemInform (2003)

Dieudonné Emmanuel Pegnyemb Raphaël Ghogomu Tih Beibam Lucas Sondengam Alain Blond Bernard Bodo

Abstract For Abstract see ChemInform Abstract in Full Text.

10.1002/chin.200402236

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Minor Biflavonoids of Lophira lanceolata

Journal of Natural Products (1994)

Dieudonné Emmanuel Pegnyemb R. Ghogomu-Tih B.L. Sondengam M.T. Martín Bernard Bodo

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMinor Biflavonoids of Lophira lanceolataD. E. Pegnyemb, R. Ghogomu-Tih, B. L. Sondengam, M. T. Martin, and B. BodoCite this: J. Nat. Prod. 1994, 57, 9, 1275–1278Publication Date (Print):September 1, 1994Publication History Published online1 July 2004Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/np50111a015https://doi.org/10.1021/np50111a015research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Biflavonoids

10.1021/np50111a015

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Citations (7)

Pro-apoptotic activity of new triterpenoid saponins from the roots of Albizia adianthifolia (Schumach.) W.Wight

Fitoterapia (2018)

Olivier Placide Noté Eutrophe Le Doux Kamto Daniel Djou Toukea Sarah Ali Aouazou Joséphine Ngo Mbing

Hydroxymethyl

Triterpenoid saponin

DEPT

10.1016/j.fitote.2018.06.008

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Citations (9)

In Vitro and In Silico Potential Inhibitory Effects of New Biflavonoids from Ochna rhizomatosa on HIV-1 Integrase and Plasmodium falciparum

Pharmaceutics (2022)

Angélique Nicolas Messi Susan L. Bonnet Brice Ayissi Owona Anke Wilhelm Eutrophe Le Doux Kamto

The aim of this study was to identify bioactive secondary metabolites from Ochna rhizomatosa with potential inhibitory effects against HIV and Plasmodium falciparum. A phytochemical study of O. rhizomatosa root barks resulted in the identification of three new biflavonoids (1-3), along with four known ones (4-7). Compound 7 (Gerontoisoflavone A) was a single flavonoid present in the rootbark of the plant and was used as a reference. Compound 1 (IC50 = 0.047 µM) was the only one with a noteworthy inhibitory effect against HIV-1 integrase in vitro. Chicoric acid (IC50 = 0.006 µM), a pure competitive inhibitor of HIV-1 integrase, was used as control. Compound 2 exhibited the highest antiplasmodial activity (IC50 = 4.60 µM) against the chloroquine-sensitive strain of Plasmodium falciparum NF54. Computational molecular docking revealed that compounds 1 and 2 had the highest binding score (-121.8 and -131.88 Kcal/mol, respectively) in comparison to chicoric acid and Dolutegravir (-116 and -100 Kcal/mol, respectively), towards integrase receptor (PDB:3LPT). As far as Plasmodium-6 cysteine s48/45 domain inhibition is concerned, compounds 1 and 2 showed the highest binding scores in comparison to chloroquine, urging the analysis of these compounds in vivo for disease treatment. These results confirm the potential inhibitory effect of compounds 1 and 2 for HIV and malaria treatment. Therefore, our future investigation to find inhibitors of these receptors in vivo could be an effective strategy for developing new drugs.

Dolutegravir

IC50

Docking (animal)

Phytochemical

AutoDock

10.3390/pharmaceutics14081701

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Citations (7)

Two new aggreceride derivatives and other chemical constituents from the stems of Tarenna conferta Benth and their potential antileishmanial activity against Leishmania donovani promastigotes: Insight from molecular docking analysis

Biochemical Systematics and Ecology (2025)

Raïssa Carelle Dzukoug Angélique Nicolas Messi Rostanie Dongmo Zeukang Susan L. Bonnet Anke Wilhelm

Apocynaceae

Chemotaxonomy

10.1016/j.bse.2025.104990

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