Yasumasa Hitomi

Tianjin Nankai Hospital

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Yuko Mizuno‐Matsumoto

University of Hyogo

Yoshihiro Tsuji

Morinomiya University of Medical Sciences

Takayuki Nishigaki

National Cerebral and Cardiovascular Center

Nodoka Sato

Access to Wholistic and Productive Living Institute

Naoki Suzuki

Komatsu (Japan)

Atsu Todo

University of Hyogo

Masato Nishimura

Tokushima University

Atsuko Igarashi

The University of Tokyo

Tomoyuki Tanaka

University of Dundee

Kotaro Yoshida

Fukui Prefectural Hospital

Cooperative Institutions

Kyoto University

Niigata University

Osaka University

The University of Tokyo

National Cerebral and Cardiovascular Center

Toujinkai Hospital

Kindai University

Kyushu University

University of Hyogo

Tianjin Nankai Hospital

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[CASE OF BROWN CYTOMA WITH PAROXYSMAL HYPERTENSION, WITH SPECIAL REFERENCE TO ITS DIAGNOSTIC CONSIDERATION].

PubMed (1964)

H Daiwa Yasumasa Hitomi Akira Karai Kazunari Maekawa Satoshi Hirose

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CCDC 274258: Experimental Crystal Structure Determination

The Cambridge Structural Database (2005)

Yasumasa Hitomi A Ando Hideto Matsui T. Ito Tomoyuki Tanaka

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc96d1x

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Changes in frontal lobe regional oxygen saturation in cases of intradialytic hypotension

Nihon Toseki Igakkai Zasshi (2022)

Naoki Suzuki Yuuki Takeda Takahiro Konishi Yasumasa Hitomi Nodoka Sato

脳血流の指標とされる前頭葉混合血酸素飽和度（FL‒rSO2）を，透析中に測定した血圧低下症例を3例報告する．症例1は76歳男性，オンライン血液透析濾過を施行した患者であり，開始2時間後より2度の急激な血圧低下とともにFL‒rSO2の低下が認められた．症例2は65歳女性，15分毎に50 mLの補液を行う間歇補充型血液透析濾過（少量頻回補液IHDF）を施行した患者であった．透析開始時より血圧とブラッドボリューム（BV）は低値で推移したが，FL‒rSO2は安定して推移した．症例3は68歳女性，少量頻回補液IHDFを施行した患者であり，BV低下はわずかであったが，開始3時間後より血圧低下を認め，FL‒rSO2はIHDFの補液に反応して変化した．脳血流の調節メカニズムは複雑であり，血圧やBVで管理することは難しいが，透析中のFL‒rSO2モニタリングは脳循環管理の指標として有用である可能性がある．

Oxygen Saturation

Saturation (graph theory)

10.4009/jsdt.55.327

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CCDC 762895: Experimental Crystal Structure Determination

The Cambridge Structural Database (2013)

Yasumasa Hitomi Junya Ohyama Yoshiki Higuchi K. Aoki T. Shishido

10.5517/cctlvjr

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Physio-psychological study on enteric capsules containing bifidobacteria for hemodialysis patients

Nihon Toseki Igakkai Zasshi (2015)

Yoshihiro Tsuji Kentaro Yoshioka M. Kohno Naoki Suzuki Nobuhiro Tajiri

腸溶性カプセル化ビフィズス菌製剤 (以下, カプセル化ビフィズス菌製剤) を透析患者に服用させ, 便秘症状の改善とそれに伴うQOL, および血液検査結果の変化について検討した. 透析患者24名を対象とし, カプセル化ビフィズス菌製剤を1日1包8週間服用させた. 便秘の尺度評価には日本語版便秘評価尺度を用い, QOLの変化にはThe Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) を用いた. カプセル化ビフィズス菌製剤摂取前と比較して, 21名 (87.5%) に便秘症状の改善とQOLの向上が認められた. また, 早期に便秘が改善した群では血清リン値が有意に低下した. カプセル化ビフィズス菌製剤摂取の効果が早発性に出現する透析患者では, 便秘症状の改善に伴うQOLの向上, および血清リン値の低下に有用であることが示唆された.

10.4009/jsdt.48.413

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Relationship between Dream Anxiety in Recurrent Nightmare and Indefinite Complaints in Patients Undergoing Maintenance Hemodialysis: A Cross-sectional Study

International Journal of Affective Engineering (2018)

Yoshihiro Tsuji Naoki Suzuki Yasumasa Hitomi Yusuke Sakai Toshiko Tokoro

The objective of this study was to investigate the relationship between recurrent nightmare and indefinite complaints and to determine the explanatory variables of indefinite complaints related to nightmares in hemodialysis (HD) patients. Sleep quality and dream anxiety in nightmare were assessed with the Athens Insomnia Scale and Van Dream Anxiety Scale. Using a visual analog scale and the Beck Depression Inventory, we assessed the presence of indefinite complaints and levels of depressive symptoms, respectively. Moreover, logistic regression analysis was performed to determine the risk factors of dream anxiety in recurrent nightmare. The presence of feelings of malaise was an independent risk factor of recurrent nightmare (OR, 1.360; p = 0.0083). Adjustment for the presence of feelings of malaise could help to reduce the frequency of nightmares or sleep disorders in patients undergoing HD treatment. Our findings will be useful when considering adjustment of the HD dose.

Nightmare

Malaise

Depression

10.5057/ijae.ijae-d-18-00004

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Association Between the Distributions of Mean Corpuscular Hemoglobin and Red Blood Cell, and Mortality in a 3-Year Retrospective Study of Hemodialysis Patients

International Journal of Biomedical Engineering and Clinical Science (2020)

Yoshihiro Tsuji Yasumasa Hitomi Naoki Suzuki Yuko Mizuno‐Matsumoto Toshiko Tokoro

Introduction: A red blood cell (RBC) concentration of 300 to 350×10⁴/μL and mean corpuscular hemoglobin (MCH) concentration of 30 to 35 pg have been proposed as management target values from the relationship of Hb=RBC×MCH to control anemia, wherein Hb levels should not exceed 12 g/dL. In contrast, even in patients whose Hb levels are maintained at 10 to 12 g/dL, Hb levels are widely distributed when divided into RBC and MCH. Objective: We examined the prognosis in the distribution of MCH and RBC. Methods: Patients were classified into two groups based on MCH and RBC values, wherein patients with MCH≥30 pg but<35 pg and RBC≤350×10⁴/μL (Group I, n=177); and MCH<30 pg and RBC>350×10⁴/μL (Group II, n=217). Associations between all-cause mortality and the distributions of MCH and RBC as well as the iron profiles of these two groups were assessed by Kaplan-Meier curves and Cox proportional hazards regression model, respectively. Results: Patients with MCH<30 pg and RBC>350×10⁴/μL (Group II, n=217) had an increased long-term risk of death and a higher rate of iron deficiency than patients with MCH≥30 pg but<35 pg and RBC≤350×10⁴/μL (Group I, n=177). Conclusions: The management goal for renal anemia would be to control MCH within the range of 30−35 pg and RBC within the range of 300−350×10⁴/μL, and to avoid absolute iron deficiency.

Mean corpuscular hemoglobin

Red Cell

10.11648/j.ijbecs.20200602.13

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Association between salt intake and long-term mortality in hemodialysis patients: A retrospective cohort study

PLoS ONE (2021)

Naoki Suzuki Yasumasa Hitomi Hiroya Takata Shinji Ushiya Masahiro Yamada

The association between salt intake and clinical outcomes in hemodialysis patients has been controversial. This study aimed to clarify the association between salt intake and mortality in hemodialysis patients.The present study included patients who underwent hemodialysis from June 1st 2016 to May 31st 2020. Corrected salt intake by ideal body weight was the main predictor of outcomes. Ideal body weight was calculated assuming that the ideal body mass index is 22 kg/m2 for the Japanese population. The multivariate Cox proportional hazards model was used to determine the association between corrected salt intake and mortality, adjusting for potential confounders. The outcomes considered were all-cause mortality and cumulative incidence of cardiovascular events at year 4.A total of 492 adult patients were enrolled in the study. The mean daily salt intake and corrected salt intake at baseline were 9.5 g/day and 0.17 g/kg/day, respectively. The low corrected salt intake group (< 0.13 g/kg/day) demonstrated the highest 4-year all-cause mortality. No association was observed between corrected salt intake and the cumulative incidence of cardiovascular events. In multivariate Cox proportional hazards analysis, only the group with corrected salt intake of 0.16-0.20 g/kg/day was associated with a decreased hazard risk for all-cause death compared with the low corrected salt intake group.The present study found that a low salt intake was associated with high all-cause mortality in hemodialysis patients. Reduced long-term survival may be attributed to malnutrition resulting from excessive salt restriction.

Cumulative incidence

10.1371/journal.pone.0260671

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In vitro evaluation of a new heating system of extracorporeal membrane oxygenation (ECMO) system for children

World Automation Congress (2010)

Takayuki Nishigaki Teruyuki Hayashi Yūzō Takahashi Kotaro Yoshida Yasumasa Hitomi

We proposed a new heating system (NHS) for an ECMO for children. This time we studied the heat retention effects and condensation prevention effects of the NHS with basic experiments. The experimental equipment consisted of three elements: the NHS, an experimental ECMO system, and an experimental heat exchanger. The NHS consisted of a convective air warming system and a vinyl sheet to cover the ECMO system. The first experimental method recorded the transitions in the circulating water temperature in the ECMO system for each of 8 types of ECMO management methods. Another test method studied whether condensation occurred in the NHS equipment and in the control equipment over 12 hours of ECMO operation. The results showed that the NHS has the heat exchange performance and the condensation prevention effect needed for ECMO management. This strongly suggested that the NHS most likely be put into practical use.

Membrane oxygenator

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Influence of differences in vasodilatory capacity in shunt stenosis on treatment results and inspection standards

Nihon Toseki Igakkai Zasshi (2022)

Yasumasa Hitomi Naoki Suzuki Yoshihiro Tsuji Hiroya Takada Masahiro Yamada

【目的】シャント狭窄部に駆血を行うことで血管拡張が得られる症例とそうでない症例で,治療成績や検査基準に違いがあるかどうかを検討した.【対象】対象は,非駆血時での狭窄部血管断面積が3.14 mm2(径で2.0×2.0 mm)以下で,エコー下VAIVTを実施した96例である.【方法】対象を,駆血で狭窄部血管径が拡張する血管拡張良好群と拡張しない血管拡張不良群に分類し,両群のVAIVT前での非駆血時狭窄部断面積,FV,RI,および治療での最高拡張圧,過去3年間のVAIVT回数などを統計学的に比較した.【結果・考察】血管拡張良好群の治療効果は血管拡張不良群よりも低い可能性が高く,血管拡張良好群の非駆血時の狭窄径は見かけ上の有意狭窄である可能性が示唆された.非駆血状態で狭窄部の径計測を行い,それのみをVAIVT介入の基準とした場合,過剰な治療介入が存在する可能性がある.治療適応を考査する際には,駆血したうえで狭窄部の径計測を行う必要がある.

10.4009/jsdt.55.167

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