María del Carmen Lara

Benemérita Universidad Autónoma de Puebla

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Nadia Bianchi‐Berthouze

University College London

Luis Enrique Sucar

National Institute of Astrophysics, Optics and Electronics

Lorena Palafox

Instituto Nacional de Neurología y Neurocirugía

Jesús Joel Rivas

National Institute of Astrophysics, Optics and Electronics

Felipe Orihuela‐Espina

University of Birmingham

Jorge Hernández-Franco

Instituto Nacional de Neurología y Neurocirugía

ÓB

Óscar Barroso Fernández

Universidad de Granada

José Luis Mora García

Universidad Autónoma de Madrid

José Cortés

The University of Texas at San Antonio

Xavier Agenjo Bullón

Fundación Ignacio Larramendi

Cooperative Institutions

Instituto Nacional de Psiquiatría

National Institute of Astrophysics, Optics and Electronics

Instituto Nacional de Neurología y Neurocirugía

Universidad Nacional Autónoma de México

University College London

Benemérita Universidad Autónoma de Puebla

Universidad Autónoma de Madrid

Instituto Politécnico Nacional

Imperial College London

Universidad Autónoma Metropolitana

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Failure of Tibolone to Potentiate the Pharmacological Effect of Fluoxetine in Postmenopausal Major Depression

Journal of Women s Health (2003)

Carlos Berlanga Danelia Mendieta Guadalupe Alva María del Carmen Lara

Background: Perimenopausal depression has been attributed to physiological progressive estrogen decline. Estrogen and derivatives have some mood-enhancing effects, although studies of using estrogen as an antidepressant have had mixed results. The gonadomimetic drug tibolone stimulates estrogen receptors in a tissue-selective fashion, increasing the gonadal activity without causing some of the usual side effects of other estrogen preparations. Methods: A total of 31 postmenopausal outpatients with a major depressive disorder (MDD) participated in the study. Sixteen received the antidepressant fluoxetine (20 mg/day) plus tibolone (2.5 mg/day), and 15 received the same dose of fluoxetine plus placebo, assigned in a randomized fashion. Results: After 8 weeks of treatment, the two groups had a similar level of improvement in their depressive symptoms. Both treatments were well tolerated, without significant side effects. Pretreatment and posttreatment serum hormonal levels did not predict the final response. Conclusions: Combining tibolone and fluoxetine did not represent a more robust antidepressant response than fluoxetine alone in postmenopausal women with MDD.

Tibolone

Depression

10.1089/154099903321154121

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La creatividad y la psicopatología

Salud Mental (2000)

Rosa Aurora Chávez María del Carmen Lara

Resumen en: What is the relation between creativity and psychopathology? Does psychopathology facilitate creativity? Does creative activity induce psychopathology?...

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El abandono del tratamiento psiquiátrico: motivos y contexto institucional

Revista de Psicología (2000)

Alejandro Velázquez R.Juan José Sánchez Sosa María del Carmen Lara Héctor Sentíes

Para documentar la permanencia en tratamiento de pacientes de una institución de salud mental y sus motivos de abandono, se analizaron 314 expedientes clínicos (177 mujeres y 137 hombres) Se contactó al total de pacientes localizables (64) en un análisis retrospectivo que cubrió siete años. Los resultados revelaron un porcentaje acumulativo de abandono del tratamiento superior a 70% sin tendencias atribuibles a edad, sexo o lugar de residencia. La categoría diagnóstica orgánico mostró un porcentaje de abandono ligeramente superior aunque inconsistente de año a año. Los motivos de abandono más frecuentes incluyeron los siguientes: sentirse mejor (19.6%), atenderse en otra institución (17 .4%), falta de recursos económicos (10.9% ), motivos no tipificados (7.6%), efectos colaterales de medicamentos prescritos (6.5%) y maltrato del tratante (6.5%). Se destaca la necesidad de diseñar e instrumentar intervenciones psicológicas para mejorar la atención y promover la adherencia terapéutica.

10.18800/psico.200002.005

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Unobtrusive Inference of Affective States in Virtual Rehabilitation from Upper Limb Motions: A Feasibility Study

IEEE Transactions on Affective Computing (2018)

Jesús Joel Rivas Felipe Orihuela‐Espina Lorena Palafox Nadia Bianchi‐Berthouze María del Carmen Lara

Virtual rehabilitation environments may afford greater patient personalization if they could harness the patient's affective state. Four states: anxiety, pain, engagement and tiredness (either physical or psychological), were hypothesized to be inferable from observable metrics of hand location and gripping strength-relevant for rehabilitation. Contributions are; (a) multiresolution classifier built from Semi-Naïve Bayesian classifiers, and (b) establishing predictive relations for the considered states from the motor proxies capitalizing on the proposed classifier with recognition levels sufficient for exploitation. 3D hand locations and gripping strength streams were recorded from 5 post-stroke patients whilst undergoing motor rehabilitation therapy administered through virtual rehabilitation along 10 sessions over 4 weeks. Features from the streams characterized the motor dynamics, while spontaneous manifestations of the states were labelled from concomitant videos by experts for supervised classification. The new classifier was compared against baseline support vector machine (SVM) and random forest (RF) with all three exhibiting comparable performances. Inference of the aforementioned states departing from chosen motor surrogates appears feasible, expediting increased personalization of virtual motor neurorehabilitation therapies.

Neurorehabilitation

10.1109/taffc.2018.2808295

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Automatic recognition of pain, anxiety, engagement and tiredness for virtual rehabilitation from stroke: A marginalization approach

Jesús Joel Rivas Lorena Palafox Jorge Hernández-Franco María del Carmen Lara Nadia Bianchi‐Berthouze

Virtual rehabilitation taps affective computing to personalize therapy. States of anxiety, pain and engagement (affective) and tiredness (physical or psychological) were studied to be inferable from metrics of 3D hand location-proxy of hand movement- and fingers' pressure relevant for upper limb motor recovery. Features from the data streams characterized the motor dynamics of 2 stroke patients attending 10 sessions of motor virtual rehabilitation. Experts tagged states manifestations from videos. We aid classification contributing with a marginalization mechanism whereby absent input is reconstructed. With the hand movement information absent, marginalization statistically outperformed a base model where such input is ignored. Marginalized classification performance was (Area below ROC curve: μ ± σ) 0.880 ± 0.173 and 0.738 ± 0.177 for each patient. Marginalization aid classification sustaining performance under input failure or permitting different sensing settings.

Proxy (statistics)

Motor Imagery

Stroke

10.1109/aciiw.2017.8272607

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AFECTACIÓN EXTRAPULMONAR DE LA TBC

Seram (2018)

Sara Higuero Hernando María del Carmen Lara Felicicana Agustín Cembellín Juan Ramón Olivo Esteban Manuel Ángel Martín Pérez

Objetivos DocentesConocer las diferentes localizaciones donde puede asentar una infeccion tuberculosa fuera del pulmon asi como describir los hallazgos radiologicos caracteristicos. Revision del temaEl termino tuberculosis describe un conjunto de entidades clinicas causadas por Mycobacterium tuberculosis (M. tuberculosis) o menos frecuentemente por Mycobacterium bovis. El organo que fundamentalmente se afecta es el pulmon, pero la tuberculosis puede afectar practicamente a cualquier organo y de forma tipica se asocia a la formacion de granulomas.

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La benevolencia. Genealogía de una virtud política ilustrada

Revista de hispanismo filosófico (2012)

María del Carmen Lara

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Filosofías del sur. Actas de las XI Jornadas Internacionales de la Asociación de Hispanismo Filosófico

José Luis Mora García María del Carmen Lara Óscar Barroso Fernández Elena Trapanese Xavier Agenjo Bullón

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