АН

А. Н. Баландина

Center for Theoretical Problems of Physicochemical Pharmacology

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Mikhail A. Panteleev

Center for Theoretical Problems of Physicochemical Pharmacology

ФИ

Фазоил И. Атауллаханов

Center for Theoretical Problems of Physicochemical Pharmacology

E. M. Koltsova

Center for Theoretical Problems of Physicochemical Pharmacology

Alexey M. Shibeko

Center for Theoretical Problems of Physicochemical Pharmacology

Anna D. Kuprash

Center for Theoretical Problems of Physicochemical Pharmacology

ФИ

Ф. И. Атауллаханов

Center for Theoretical Problems of Physicochemical Pharmacology

A. V. Poletaev

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology

E. A. Seregina

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology

АM

А. M. Podurets

Institute of Experimental Physics of the Slovak Academy of Sciences

M. I. Tkachenko

All-Russian Scientific Research Institute of Technical Physics

Cooperative Institutions

Ministry of Health of the Russian Federation

National Research Center for Hematology Russian Academy of Medical Sciences

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology

Russian Academy of Sciences

Center for Theoretical Problems of Physicochemical Pharmacology

All-Russian Scientific Research Institute of Technical Physics

Lomonosov Moscow State University

Los Alamos National Laboratory

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Sarov Institute of Physics and Technology

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Replication data for: Enhanced clot growth rate before cycle of in vitro fertilization decreases probability of pregnancy Description_for_Dataset.docx

Harvard Dataverse (2018)

E. M. Koltsova А. Н. Баландина Tatyana Teterina Alexandra Yakovenko Е.С. Симоненко

Replication

10.7910/dvn/lcog1i/hniwks

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New approaches to the diagnosis and treatment of coagulation disorders

Pediatric Hematology/Oncology and Immunopathology (2020)

Alexey M. Shibeko А. Н. Баландина Mikhail A. Panteleev

With the advent of new approaches in coagulation studies capable of identifying regulatory mechanisms involved in transport processes, the spatial localization of processes and interaction between the coagulation system and the immune system, the complement system, and fibrinolysis, the existing diagnostic and treatment approaches used in clinical and laboratory practice are changing as well. This review describes modern diagnostic methods for hemostasis disorders that are based on an integrative approach and are used to assess many aspects of the coagulation system at once. The reviewed methods are sensitive not only to bleeding but also to prothrombotic states, and enable monitoring of treatment with various medications including both oral anticoagulants and antihemophilic agents. We will also cover new approaches to the treatment of hemostasis disorders made possible by the understanding of the involved control mechanisms, such as the use of bispecific antibodies as an alternative to coagulation cofactors, the inhibition of inhibitors and the development of new drug delivery techniques.

10.24287/1726-1708-2020-19-4-243-250

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Citations (1)

Laboratory tests for coagulation system monitoring in a patient with beta-thalassemia

International Journal of Laboratory Hematology (2014)

E. A. Seregina О. Ф. Никулина Н. В. Цветаева Maya N. Rodionova И. В. Грибкова

Beta thalassemia

BETA (programming language)

Coagulation system

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The NMR investigation of the electromagnetic irradiation effects on bacteria

The Physics of Metals and Metallography (2006)

Т. В. Дрокина V. V. Lisin L. Popova А. Н. Баландина M. A. Bitekhtina

Photobacterium

Strain (injury)

10.1134/s0031918x06140250

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Helical EMG application for aluminum rheology studies

А. Н. Баландина P. V. Duday V. I. Dudin A.M. Glybin В. А. Иванов

To study the peculiarities of initiation, evolution and recollection of spall-type damage under axis-symmetric convergence using the impact method, the test bench with an explosive magnetic pulsed power source (EPPS) on the basis of a helical generator with an explosive opening switch and a current interrupter has been created. The EPPS allows shaping the trapezoidal current pulses with the amplitude from 4 MA to 12 MA, full base duration from 10 to 250 μs and front rise duration ~ 2 μs in the load (liner). The magnetic field produced by the EMG current ensures the isentropic drive of a cylindrical liner used to create a shock wave of the required characteristics in the targets. In experiments "R-Damage-8,9" representing the completion stage of the experimental series "R-Damage-0-9" realized jointly by the VNIIEF and LANL teams we used the isentropically driven liners to realize a set of processes of shock-wave compression, evolution of damage and recollection of a damaged matter under axis-symmetric convergence in the extruded aluminum. The features of these processes were recorded with the use of PDV technique due to the time dependencies of the hollow targets' inner surface velocity. The presented method allowed apparently for the first time realizing the full and incomplete recollection of the main crack as the results of metallographic analysis have showed. This result made it possible to verify the numerical models of the damaged medium recollection being developed at the present time.

10.1109/megagauss.2012.6781422

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The laboratory control of anticoagulant thromboprophylaxis during the early postpartum period after cesarean delivery

Journal of Perinatal Medicine (2017)

E. M. Koltsova А. Н. Баландина Konstantin I. Grischuk Margarita A. Shpilyuk E. A. Seregina

The incidence of venous thromboembolism (VTE) after cesarean section is up to 0.6%, and the widespread use of cesarean section draws attention to this group. The dosage and duration of low-molecular-weight heparin (LMWH) prophylaxis after delivery is estimated by anamnestic risk-scales; however, the predictive potency for an individual patient's risk can be low. Laboratory hemostasis assays are expected to solve this problem. The aim of this study was to estimate the potency of tests to reflect the coagulation state of patients receiving LMWH in the early postpartum period.We conducted an observational study on 97 women undergoing cesarean section. Standard coagulation tests (Fg, APTT, prothrombin, D-dimer), an anti-Xa assay, rotation thromboelastometry and thrombodynamics/thrombodynamics-4D were performed. Coagulation assay parameters were compared in groups formed in the presence or absence of LMWH to estimate the laboratory assays' sensitivity to anticoagulation.Coagulation assays revealed hypercoagulation after delivery and a tendency toward normalization of coagulation during early postpartum. The thromboprophylaxis results revealed a higher percentage of coagulation parameters within the normal range in the LMWH group.This research is potentially beneficial for the application of thrombodynamics and thrombodynamics-4D in monitoring coagulation among patients with high VTE risk who receive thromboprophylaxis with heparin.

Coagulation testing

Thromboelastometry

10.1515/jpm-2016-0333

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Citations (25)

Laboratory Parameters of Blood Coagulation and Platelet Functional Activity in Premature Neonates

American Journal of Perinatology (2016)

E.N. Balashova E. M. Koltsova Anastasia A. Ignatova Dmitry M. Polokhov Anna D. Kuprash

Introduction: Premature birth is associated with significant risks of mortality and morbidity due to hemorrhage and thrombosis. However, the status of hemostatic system in premature neonates is poorly known, and almost all data in this area derive from blood samples obtained from cord blood.

Cord blood

Premature newborn

Premature birth

10.1055/s-0036-1592386

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Citations (3)

Пороговые свойства системы свертывания крови in vitro при активации тканевым фактором

А. Н. Баландина

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Replication data for: Enhanced clot growth rate before cycle of in vitro fertilization decreases probability of pregnancy

Harvard Dataverse (2018)

E. M. Koltsova А. Н. Баландина Tatyana Teterina Alexandra Yakovenko Е.С. Симоненко

Here we deposit the data on coagulation assays results of 125 patients enrolled in the study by Balandina et al. "Enhanced clot growth rate before cycle of in vitro fertilization decreases probability of pregnancy"

Replication

10.7910/dvn/lcog1i

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Hypercoagulation detected by routine and global laboratory hemostasis assays in patients with infective endocarditis

PLoS ONE (2021)

E. M. Koltsova Maria Sorokina A. S. Pisaryuk N Povalyaev Anastasia A. Ignatova

Background Coagulation system is heavily involved into the process of infective endocarditis (IE) vegetation formation and can facilitate further embolization. In this study we aimed to assess the coagulation and platelet state in IE implementing a wide range of standard and global laboratory assays. We also aim to determine whether prothrombotic genetic polymorphisms play any role in embolization and mortality in IE patients. Methods 37 patients with IE were enrolled into the study. Coagulation was assessed using standard coagulation assays (activated partial thromboplastin time (APTT), prothrombin, fibrinogen, D-dimer concentrations) and integral assays (thromboelastography (TEG) and thrombodynamics (TD)). Platelet functional activity was estimated by flow cytometry. Single nuclear polymorphisms of coagulation system genes were studied. Results Fibrinogen concentration and fibrinogen-dependent parameters of TEG and TD were increased in patients indicating systemic inflammation. In majority of patients clot growth rate in thrombodynamics was significantly shifted towards hypercoagulation in consistency with D-dimers elevation. However, in some patients prothrombin, thromboelastography and thrombodynamics were shifted towards hypocoagulation. Resting platelets were characterized by glycoprotein IIb-IIIa activation and degranulation. In patients with fatal IE, we observed a significant decrease in fibrinogen and thrombodynamics. In patients with embolism, we observed a significant decrease in the TEG R parameter. No association of embolism or mortality with genetic polymorphisms was found in our cohort. Conclusions Our findings suggest that coagulation in patients with infective endocarditis is characterized by general hypercoagulability and platelet pre-activation. Some patients, however, have hypocoagulant coagulation profile, which presumably can indicate progressing of hypercoagulation into consumption coagulopathy.

Thromboelastography

Prothrombin time

10.1371/journal.pone.0261429

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Citations (16)