Chuan‐Min Yen

National Cheng Kung University

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Rong‐Jyh Lin

Kaohsiung Medical University

Susan Shin‐Jung Lee

Kaohsiung Veterans General Hospital

June‐Der Lee

Kaohsiung Medical University

Er Chen

Wenzhou Medical University

Hung‐Chin Tsai

Kaohsiung Veterans General Hospital

Li-Yu Chung

Kaohsiung Medical University

Yao-Shen Chen

Kaohsiung Veterans General Hospital

Shue-Ren Wann

Kaohsiung Veterans General Hospital

Eng-Rin Chen

Kaohsiung Medical University

Jiun-Jye Wang

Kaohsiung Medical University

Cooperative Institutions

Kaohsiung Medical University

112

National Yang Ming Chiao Tung University

Kaohsiung Veterans General Hospital

E-Da Hospital

I-Shou University

National Cheng Kung University

Kaohsiung Medical University Chung-Ho Memorial Hospital

National Sun Yat-sen University

Chang Gung University

National Cheng Kung University Hospital

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Preparation of monoclonal antibody against Angiostrongylus cantonensis antigen.

PubMed (1989)

Chuan‐Min Yen Eng-Rin Chen Soichi Kojima Masanori Kobayashi

Monoclonal antibodies (MAb) against A cantonensis were produced through fusion of immunised spleen cells from BALB/c mice with NS-1 myeloma cells at a ratio of 10:1. The successful fusion rate on the 3rd day of fusion was 90.1%. Ten MAb were characterised, six of which were IgG1 and the remaining four were IgG2a, IgG2b, IgM and IgA respectively. Among 6 IgG1 MAb, four were A. cantonensis-specific, of which three reacted to adult worm antigen only and one reacted to both adult worm and juvenile worm antigens. Two other IgG1 MAb showed cross-reaction with other helminthic antigens of Toxocara canis. Ascaris suum. Paragonimus westermani, Dirofilaria immitis, Anisakis Spp, Gnatostoma Spinigerum and Clonorchis sinensis.

Paragonimus westermani

Ascaris suum

Clonorchis sinensis

Toxocara cati

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Citations (8)

Prevalence of Cryptosporidium for Foreign Workers in Taiwan

Tropical Doctor (2004)

June‐Der Lee Ma-Li Chiu Lee-Yi Chung Chuan‐Min Yen

10.1177/004947550403400325

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Citations (3)

Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection

Korean Journal of Parasitology (2019)

Hung‐Chin Tsai Yu-Hsin Chen Chuan‐Min Yen Li-Yu Chung Shue-Ren Wann

Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform Î² and Î³ proteins significantly increased in the CSF 2â3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 Î², Î³, É, and Î¸ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges. Key words: Angiostrongylus cantonensis, dexamethasone, eosinophile, meningitis, 14-3-3 isoform

Meninges

10.3347/kjp.2019.57.3.249

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Citations (3)

VASCULAR ENDOTHELIAL GROWTH FACTOR IS ASSOCIATED WITH BLOOD BRAIN BARRIER DYSFUNCTION IN EOSINOPHILIC MENINGITIS CAUSED BY ANGIOSTRONGYLUS CANTONENSIS INFECTION

American Journal of Tropical Medicine and Hygiene (2007)

Hung‐Chin Tsai SUSAN SHIN-JUNG LEE YUNG-CHING LIU Chuan‐Min Yen ENG-RIN CHEN

Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of vascular endothelial growth factor in eosinophilic meningitis, vascular endothelial growth factor was measured in the cerebrospinal fluid (CSF) and blood of 9 patients with eosinophilic meningitis in a cohort study. VEGF CSF was detected in 8 (90%) of 9 eosinophilic meningitis patients (range, 45–2190 pg/mL) at presentation. The mean VEGF CSF at presentation, 1 week, and 2 weeks after admission was 568 pg/mL, 751 pg/mL, and 1031 pg/mL, respectively. There was an association between VEGF CSF , CSF protein, white cell count, and eosinophil counts. The VEGF SERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis.

Vascular permeability

White blood cell

10.4269/ajtmh.2007.76.592

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Citations (14)

Magnetic Resonance Imaging Findings of Eosinophilic Meningoencephalitis Caused by Angiostrongyliasis

中華放射線醫學雜誌 (2001)

Tsyh-Jyi Hsieh Gin‐Chung Liu Chuan‐Min Yen Yu‐Ting Kuo Min-Shon Chou

We report on magnetic resonance imaging (MRI) findings of eosinophilic meningoencephalitis caused by angiostrongyliasis in a 79-year-old Chinese woman. MR imaging in this case was compatible with the features of meningitis and angiostrongyliasis, including leptomeningeal thickening and microcavity formation with slight hemorrhagic and granulomatous inflammatory reaction caused by migration of worms. To our knowledge, this is the first report of MRI of eosinophilic meningoencephalitis caused by angiostrongyliasis in Taiwan.

Angiostrongyliasis

Neuroradiology

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Cytotoxic Compounds from the Stems of Cinnamomum tenuifolium

Journal of Natural Products (2009)

Rong‐Jyh Lin Ming‐Jen Cheng Jin‐Cherng Huang Wen‐Li Lo Yu-Ting Yeh

Three new butanolides, tenuifolide A (1), isotenuifolide A (2), and tenuifolide B (3), a new secobutanolide, secotenuifolide A (4), and one new sesquiterpenoid, tenuifolin (5), along with 16 known compounds were isolated from the stems of Cinnamomum tenuifolium. Their structures were determined by spectroscopic analyses. Compound 4 was found to induce apoptotic-related DNA damage, increase sub-G1 cells, and inhibit the growth of human prostate cancer cells, DU145. In addition, treatment with 4 significantly increased intracellular H2O2 and/or peroxide. The results show that 4 induced (a) noticeable reduction of mitochondrial transmembrane potential (ΔΨm); (b) significant increase in the ratio of cytochrome c concentration (cytosol/mitochondria); and (c) subsequent activation of caspase-9/caspase-3. Antiproliferation caused by 4 was found to markedly decrease when pretreated with caspase-9/caspase-3 inhibitor. In ROS scavenging, antioxidant, NADPH oxidase, and NO inhibitor studies, pretreatment of DU145 cells with either DPI, dexamethasone, l-NAME, or mannitol decreased 4-induced intracellular DCF fluorescence of ROS. These results suggest that an increase of H2O2 and/or peroxide by 4 is the initial apoptotic event and 4 has anticancer effects on DU145 cells.

DU145

Cinnamomum

Dichlorofluorescein

10.1021/np900225p

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Citations (71)

Kinetics of change in the eotaxin concentration in serum and cerebrospinal fluid of mice infected with Angiostrongylus cantonensis

Parasitology Research (2004)

Eddy Essen Chang Lee-Yi Chung Chuan‐Min Yen

10.1007/s00436-003-1017-0

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Citations (18)

Detection of antibodies to surface antigens ofAngiostrongylus cantonensisby ELISA

Annals of Tropical Medicine and Parasitology (1995)

Jih‐Hsin Chang Chuan‐Min Yen E. R. Chen Li‐Yu Chung Jeh‐Jeng Wang

10.1080/00034983.1995.11812989

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Citations (6)

Anthelmintic Activities of Aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana

International Journal of Molecular Sciences (2014)

Rong‐Jyh Lin Mei-Hsuan Wu Yi-Hsuan Ma Li-Yu Chung Chung‐Yi Chen

Nelumbo nucifera Gaertn. cv. Rosa-plena (Nelumbonaceae), commonly known as lotus, is a perennial aquatic plant grown and consumed throughout Asia. All parts of N. nucifera have been used for various medicinal purposes in oriental medicine. From the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena (an aquatic plant), liriodenine (1), lysicamine (2), (-)-anonaine (3), (-)-asimilobine (4), (-)-caaverine (5), (-)-N-methylasimilobine (6), (-)-nuciferine (7), (-)-nornuciferine (8), (-)-roemerine (9), 7-hydroxydehydronuciferine (10) and cepharadione B (11) were isolated and identification and anthelmintic activities of aporphine was evaluated against Anisakis simplex and Hymenolepis nana. This study found that the above constituents killed H. nana or reduced their spontaneous movements (oscillation/peristalsis). However, the above constituents at various concentrations demonstrated no larvicidal effect or ability to halt spontaneous parasite movement for 72 h against A. simplex, respectively. In addition, according to an assay of cestocidal activity against H. nana and nematocidal activity against A. simplex, we found that the above compounds showed greater lethal efficacy on H. nana than against A. simplex. Further investigation showed that these above constituents have effects against peroxyl radicals under cestocidal effect. Together, these findings suggest that these constituents of Nelumbo nucifera Gaertn. cv. Rosa-plena might be used as anthelmintic agents against H. nana.

Nelumbo Nucifera

Cocos nucifera

Hymenolepis nana

Aporphine

10.3390/ijms15033624

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Citations (36)

Microbiological studies on the wound infection of blackfoot disease.

PubMed (1977)

Tsaihong Yc Tsai Cc Chuan‐Min Yen

Wound infection

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