Yubang Shen

Shanghai Ocean University

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Xiaoyan Xu

Shandong Jiaotong University

Jiale Li

Anhui University

Jiale Li

Shanghai Ocean University

Hongyan Yu

Children's Hospital of Chongqing Medical University

Jianjun Fu

Ministry of Agriculture and Rural Affairs

Anqi Wang

North China University of Technology

Qingjing Zhang

Beijing Academy of Agricultural and Forestry Sciences

Lang Gui

Shanghai Ocean University

Hua Zhu

Zhejiang University of Technology

Honggang Zhao

Louisiana Department of Natural Resources

Cooperative Institutions

Shanghai Ocean University

Ministry of Agriculture and Rural Affairs

Chinese Academy of Sciences

Temasek Life Sciences Laboratory

National University of Singapore

Shanghai Jiao Tong University

Huazhong Agricultural University

Sun Yat-sen University

Chinese Academy of Fishery Sciences

University of Chinese Academy of Sciences

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Exposure to microplastics induces lower survival, oxidative stress, disordered microbiota and altered metabolism in the intestines of grass carp (Ctenopharyngodon idella)

Aquaculture and Fisheries (2022)

Xuewen Jia Yang Liu Yan He Hongyan Yu Yuting Liu

There are major gaps in illustrating the risk to freshwater fish that are exposed to environmental microplastics (MPs), even though MPs in freshwater environments has drawn much concern. To explore the potentially negative effects of microplastics on freshwater fish, grass carp (averaging 9.215 ± 0.035g) were exposed to microplastics (32–40 μm in diameter) at two environmental concentrations (100 and 1000 μg/L) for 21 days, and evaluated for physio-biochemical performance, gut microbiome, and metabolome responses. After exposure, microplastics were detected in the intestine and within basal nuclei and goblet cells hyperplasia. Antioxidant enzyme activities (superoxide dismutase and catalase) also significantly decreased within the intestines (P < 0.05). Through 16S rRNA gene sequencing analysis, a decrease in diversity and richness was observed in the MPs-H and MPs-L groups. The abundance of opportunistic pathogens increased and beneficial bacteria decreased in both MP treatments. For example, Acinetobacter and Bosea proportions were higher in the MPs-L group, while Bacteroides and Shewanella increased in the MPs-H group. Furthermore, abundance of Lactobacillus decreased both in the MPs-H and MPs-L groups. Metabolomics analysis revealed primary bile acid biosynthesis metabolism upregulated in the MPs-L and purine metabolism downregulated in the MPs-H group. Additionally, an integration analysis of the gut microbiome and metabolomics identified significant associations between several bacteria taxa and metabolites related to intestinal repair. Taken together, these results highlighted the negative effects on intestinal morphology, oxidative stress, and microbiome and emphasized the relationship between microbiota and metabolites in response to microplastics, which could provide comprehensive insights into the potential risks of MPs on freshwater fish intestines.

Metabolome

Grass carp

10.1016/j.aaf.2022.09.004

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Citations (7)

Impact of Microcystin-LR exposure on biochemical responses, transcriptomic profiles, gut microbiota, and growth performance in grass carp (Ctenopharyngodon idella)

Journal of Environmental Sciences (2024)

Runbo Li Yinghu Hao Yubang Shen Lang Gui Biao Du

Grass carp

10.1016/j.jes.2024.11.027

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Citations (0)

Current status of research on aquaculture genetics and genomics-information from ISGA 2018

Aquaculture and Fisheries (2018)

Yubang Shen Gen Hua Yue

The ISGA (International Symposium on Genetics in Aquaculture) is an important conference in the field of aquaculture genetics, which is held every three years. This year, the meeting was hosted by James Cook University, in Cairns. The conference sessions included biotechnology and functional genomics, sex control, genomic prediction, selective breeding and quantitative genetics, industrial use of genetics, genome technology, genetics of diseases and stress, genetics of nutrition, epigenetics, genomics and metabolomes, population genetics and ethics, food safety, as well as environmental risks. Many new and interesting unpublished data, including those for new aquaculture species, marker-assisted selection, genomic selection and genome editing using Crispr/Cas9 technologies, were reported at the conference. In this brief review, we highlight the novel and interesting researches on aquaculture genetics and genomics to give readers an overview of the current status and trends of aquaculture genetics and genomics research.

Population Genetics

10.1016/j.aaf.2018.11.001

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Citations (40)

MiR-217 targets TBK1 to modulate inflammatory response in grass carp following infection with Aeromonas hydrophila

Developmental & Comparative Immunology (2023)

Abdul-Razak Salifu Yifan Pang Yan He Yang Liu Yubang Shen

Grass carp

10.1016/j.dci.2022.104583

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Citations (2)

Matrix metalloproteinase 2 of grass carp Ctenopharyngodon idella (CiMMP2) is involved in the immune response against bacterial infection

Fish & Shellfish Immunology (2012)

Xiaoyan Xu Yubang Shen Jianjun Fu Feng Liu Shi-Zhao Guo

Grass carp

Hemopexin

10.1016/j.fsi.2012.05.015

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Citations (21)

LncRNA-WAS and lncRNA-C8807 interact with miR-142a-3p to regulate the inflammatory response in grass carp

Fish & Shellfish Immunology (2021)

Kun Fan Yubang Shen Xiaoyan Xu Lizhu Tao Tianjie Bao

Grass carp

Inflammatory response

10.1016/j.fsi.2021.02.003

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Citations (15)

miR-130a targets CiGadd45bb to modulate the inflammatory response to bacterial infection in Ctenopharyngodon idella kidney (CIK) cells

Fish & Shellfish Immunology (2023)

Yuan Fang Shengzhen Jin Xiaoyan Xu Yubang Shen Quan Wang

Grass carp

Proinflammatory cytokine

10.1016/j.fsi.2023.108633

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Genomic Basis of Striking Fin Shapes and Colors in the Fighting Fish

Molecular Biology and Evolution (2021)

Le Wang Fei Sun Zi Yi Wan Baoqing Ye Yanfei Wen

Resolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of colors, long-fin varieties, and hyper-aggressive behavior in the air-breathing Siamese fighting fish (Betta splendens), supplying an excellent system for studying the genomic basis of phenotypic variations. Combining whole-genome sequencing, quantitative trait loci mapping, genome-wide association studies, and genome editing, we investigated the genomic basis of huge morphological variation in fins and striking differences in coloration in the fighting fish. Results revealed that the double tail, elephant ear, albino, and fin spot mutants each were determined by single major-effect loci. The elephant ear phenotype was likely related to differential expression of a potassium ion channel gene, kcnh8. The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double-tail mutant was suggested to be caused by a deletion in a zic1/zic4 coenhancer. Our data highlight that major loci and cis-regulatory elements play important roles in bringing about phenotypic innovations and establish Bettas as new powerful model to study the genomic basis of evolved changes.

Genetic architecture

10.1093/molbev/msab110

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Citations (46)

Molecular cloning, tissue distribution and food intake regulatory effects ofghrelin in grass carp (Ctenopharyngodon idellus)

JOURNAL OF FISHERIES OF CHINA (2012)

Yong Chen Jiale Li Yubang Shen Jianjun Fu Rongquan Wang

Grass carp

Cloning (programming)

Tissue distribution

10.3724/sp.j.1231.2012.27928

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