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Csaba András

Sapientia Hungarian University of Transylvania

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Péter András

Edinburgh Napier University

István Hajdú

HUN-REN Research Centre for Natural Sciences

Judit Gálicza

Universitatea Națională de Știință și Tehnologie Politehnica București

R. V. Salamon

Sapientia Hungarian University of Transylvania

György Dormán

Innostart (Hungary)

Éva György

Sapientia Hungarian University of Transylvania

Beáta Flachner

Institute of Molecular Life Sciences

Éva Laslo

Sapientia Hungarian University of Transylvania

Csilla Albert

Sapientia Hungarian University of Transylvania

Dan Wan

Hunan Academy of Traditional Chinese Medicine

Cooperative Institutions

Sapientia Hungarian University of Transylvania

Russian Academy of Sciences

Universitatea Națională de Știință și Tehnologie Politehnica București

Institute of Evolutionary Physiology and Biochemistry

United States Food and Drug Administration

Budapest University of Technology and Economics

St Petersburg University

University of Southern California

National Institutes of Health

Sapientia College of Theology of Religious Orders

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Target identification and polypharmacology of nutraceuticals

Elsevier eBooks (2021)

György Dormán Beáta Flachner István Hajdú Csaba András

Nutraceuticals are mostly multitarget agents that affect the cellular signaling systems in various stages. The multitarget feature of the herbal components allows interactions with several targets that might cooperate in a synergistic way. In order to elucidate the exact molecular mechanism the nutraceuticals exhibit, identification of their beneficial effects at the so-called “efficacy targets” (direct or indirect “networked” protein targets) is extremely important. The completion of the human genome project has accelerated the development of the target identification methods and many of the traditional techniques were revisited and upgraded. In this chapter, the multitarget or polypharmacology aspects of the nutraceuticals are discussed, and this is then followed by a detailed overview of the contemporary procedures for the identification of the direct molecular targets of the most important active nutraceutical components.

Nutraceutical

Identification

10.1016/b978-0-12-821038-3.00023-9

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Citations (3)

Egy szociológiai beszédmód hegemóniája : Kultúra és kapitalizmus. Fordulat (30), 2022/1. 315. o.

A recenzió a Fordulat folyóirat harmincadik, „Kultúra és kapitalizmus” című számát vizsgálja. A bírálat méltatja a kiadvány szövegeit, majd a bevezető írás és a programadó tanulmány elemzésével rámutat a folyóiratszám céljai és javasolt módszertana közötti feszültségre. A kritika bemutatja, hogy bár a Fordulat harmincadik száma ennél többre vállalkozik, programjában a kulturális termelés politikai gazdaságtanának szempontrendszere kiszorítja azokat a kritikai diskurzusokat, melyeknek a termelt kultúra sajátosságairól lenne mondanivalójuk.

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Antibiotic resistance pattern of the allochthonous bacteria isolated from commercially available spices

Food Science & Nutrition (2021)

Éva György Éva Laslo M Antal Csaba András

Abstract Spices are often used in dried form, sometimes with significant microbial contamination including pathogenic and food spoilage bacteria. The antibiotic resistance represents an additional risk for food industry, and it is worthy of special attention as spices are important food additives. During our work, we examined the microbiological quality of 50 different spices with cultivation methods on diverse selective media. The identification of the most representative bacteria was carried out using 16S rDNA gene sequence analysis. Antibiotic resistance profiling of twelve identified Bacillus species ( B. subtilis subsp. stercoris BCFK, B. licheniformis BCLS, B. siamensis SZBC, B. zhangzhouensis BCTA, B. altitudinis SALKÖ, B. velezensis CVBC, B. cereus SALÖB isolate, B. tequilensis KOPS, B. filamentosus BMBC, B. subtilis subsp. subtilis PRBC2, B. safensis BMPS, and B. mojavensis BCFK2 isolate) was performed using the standard disk‐diffusion method against 32 antibiotics. The study showed that the majority resistance was obtained against penicillin G (100%), oxacillin (91.67%), amoxyclav (91.67%), rifampicin (75%), and azithromycin (75%). Our findings suggest that spices harbor multidrug‐resistant bacteria.

Cereus

Pathogenic bacteria

10.1002/fsn3.2433

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Citations (22)

List of Contributors

Elsevier eBooks (2016)

Abul H. Ahmad Arturo Anadón Rashmi Anand Vellareddy Anantharam Csaba András

10.1016/b978-0-12-802147-7.00080-2

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Study of Antioxidant Activity of Garden Blackberries (Rubus fruticosus L.) Extracts Obtained with Different Extraction Solvents

Applied Sciences (2022)

Csilla Albert Georgiana Gabriela Codinǎ Melinda Héjja Csaba András Ancuța Chetrariu

Blackberries are rich in antioxidants due to their high polyphenol and vitamin content, making them an excellent source of health protection. It is well known that good quality juices and fruit extracts can be obtained only from high quality fruits. The aim of this research is to characterize the antioxidant properties of garden blackberries fruits grown in Turia (Romania). Extracts were made from blackberry fruits with four different solvents, and the antioxidant capacity was studied by applying DPPH and FRAP assay. The total phenolic content (with Folin–Ciocâlteu reagent), total anthocyanin content (with the pH differential method), and total flavonoid content (with aluminum chloride colorimetric method) were also measured. The quercetin and gallic acid content were also determined by HPLC-DAD. As the best results were obtained with 90% v/v acidified acetonitrile, the Hansen parameters analysis was performed for the acetonitrile-water solvent mixture as a solvent and cyanidin-3-O-glucoside as a solute.

Aluminium chloride

10.3390/app12084004

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Increasing the Prediction Efficiency of Hansen Solubility Parameters in Supercritical Fluids

Periodica Polytechnica Chemical Engineering (2019)

Csaba András László Mátyás Botond Ráduly R. V. Salamon

This work describes a simplified method developed for calculating the Hansen parameters (HSPs) for scCO2-polar modifier solvent mixtures. The method consists in fitting 2nd order equations on the calculated values of HSPs of pure components in function of pressure and temperature. It has been proved that these equations are suitable for the characterization of the above system. The current work also proposes a modified representation method, which eliminates the shortcomings of the original ternary Teas diagram, normally used for the representation of the Hansen parameters. On the one hand, the Teas diagram uses quantities without any physical meaning and, on the other hand, the illustration of the solubility information is distorted because it does not take into account the differences of the Hildebrand parameters of different solvents. The factors we have chosen to represent on the ternary diagram possess physical meaning (cohesion energy density partitions). The distortion was eliminated by extending the Teas diagram to a prismatic three dimensional representation. We proved that the Hansen-ellipsoid from the Cartesian coordinate system (dd = f (δH, dp)) is transformed in an ellipsoid also in the new coordinate system (the transformation is pseudo-isomorphic). Nonetheless, the suggested corrections improve the accuracy of the Hansen method, in some cases the interactions between the solvents and the dissolved materials are still not predicted with sufficient accuracy. Most probably a thermodynamic-based correction of the values of the HSPs of small molecules could lead to a significant improvement of the predictive ability of the newly developed method.

Representation

Ellipsoid

Hildebrand solubility parameter

10.3311/ppch.12780

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The origins of life – the ‘protein interaction world’ hypothesis: protein interactions were the first form of self-reproducing life and nucleic acids evolved later as memory molecules

Medical Hypotheses (2005)

Péter András Csaba András

Protocell

Abiogenesis

10.1016/j.mehy.2004.11.029

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Citations (35)

生命の起原のタンパク質相互作用ワールド仮説( ISOLAB '05プロシーティング)

Viva origino (2006)

Péter András Csaba András

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Citations (1)

Structural characterization of an endoglucanase from Serpula lacrymans var. lacrymans S7.9

Nature Precedings (2011)

Csaba Zoltan Kibedi Szabo Csaba Zoltan Kibedi Szabo Judit Gálicza István Weyda Csaba András

Characterization

10.1038/npre.2011.6575

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Essential oil extraction from herbs and their use in the food industry

Acta Agraria Debreceniensis (2018)

Csaba András Bernadett Salamon Éva György Emőke Mihok Alexandru Szép

Essential oil extraction of wild caraway and thyme was performed using a classical (HD) and microwave hydro-distillation (MWHD) and a laboratory supercritical fluid extraction (SFE) with a carbon dioxide as solvent. Our experiments demonstrated that the extraction yield of the essential oil performed in same conditions was influenced by the location of growth area; the maximum extraction yield of 10 ml 100 g-1 caraway was obtained from dried seeds collected from Csíkmadaras. This quantity far exceeded the yield of the Újtusnád samples. In the case of wild caraway (Carum carvi L.), the extraction method influenced thecomposition of the essential oil (carvone/limonene ratio), the highest limonene content being achieved by classical hydro-distillation. In the case of thyme, this effect was not detected, the thymol/carvacrol ratio was independent from the given extraction method. The obtained thyme essential oil possesses high antimicrobial activity demonstrated by agar diffusion test. The thyme extract provides a good protection against microorganisms collected on the surface of fresh vegetables following bacterial stains: Citrobacter portucalensis, Pseudomonas hunanensis, Pseudomonas baetica, Pseudomonas parafulva, Bacillus mojavensis and Enterobacter cloacae. Protective effect was also detected on the vegetable surface of by chitosan-based edible film coating during a 6-day-long storage period at a temperature of 4 °C. The caraway essential oil used as soft cheese seasoning with a direct, dilution-free method, proved to be unsuitable because the uneven distribution and confer a strong, unpleasant taste to the product in comparison with the ground wild caraway seed-dressed cheese.

Carvacrol

Carvone

Thymol

Enterobacter cloacae

10.34101/actaagrar/150/1702

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Citations (3)