Liya E. Yu

Northumbria University

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Liming Yang

National University of Singapore

Choon Nam Ong

National University of Singapore

Jeffrey S. Reid

United States Naval Research Laboratory

Huijuan Mu

China Medical University

Lynn M. Hildemann

Stanford University

Madhumita B. Ray

Western University

Min-Hong Zhang

Chinese PLA General Hospital

D. R. Blake

University of California, Irvine

K. Hidajat

National University of Singapore

Guowei Pan

China Medical University

Cooperative Institutions

National University of Singapore

106

National Institute of Standards and Technology

Center for Nanoscale Science and Technology

Chinese Academy of Sciences

National Institute of Standards

Nanyang Technological University

University of Maryland, College Park

North Carolina State University

Physical Measurement Laboratory

Shandong University

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Circular RNA Hsa_circRNA_101996 promotes the development of Gastric Cancer via Upregulating Matrix Metalloproteinases-2/Matrix Metalloproteinases-9 through MicroRNA-143/Ten-eleven translocation-2 Pathway

Journal of Cancer (2021)

Feng Huang Jiajia Jiang Yongliang Yao Shiyue Hu He Wang

Background:The long-term survival rate of gastric cancer (GC) patients at advanced stages remains low worldwide.Circular RNAs (circRNAs) a newly studied type of non-coding RNA that play an important role in the pathogenesis and diagnosis of various diseases.In this research, we aimed to explore the functions of hsa_circRNA_101996 in GC cells and an animal model of GC.Methods: The expression of hsa_circRNA_101996, microRNA (miR)-143, and ten-eleven translocation (TET)-2 in GC tissues, the adjacent tissues, and cell lines were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Transwell assays were used to analyze the knockdown effects of hsa_circRNA_101996, miR-143, and overexpression of TET2 on cell proliferation, migration, and invasion abilities.Western blotting was used to analyze the expression of matrix metalloproteinases (MMP)2/MMP9.Binding interactions between, hsa_circRNA_101996 and miR-143 and between, miR-143 and TET2 were detected by Dual-luciferase reporter assays.Levels of protein expression were analyzed by Western blotting.Tumor models were established by subcutaneous injection of tumor cells in Bl6/Rag2/GammaC double knockout mice.Results: The result showed that hsa_circRNA_101996 expression was significantly upregulated in GC tissues compared to that in the adjacent tissues, and its level in cancer tissue was correlated with tumor size, lymphatic metastasis, and distant metastasis.Compared with the low hsa_circRNA_101996 expression group, the three-year survival rate of patients in the high hsa_circRNA_101996 expression group was significantly lower.The knockdown of hsa_circRNA_101996 dramatically suppressed the cell migration, invasion, and proliferation of GC cells by sponging to absorb miR-143 and elevated the expression of TET2.In vivo studies showed that the knockdown of hsa_circRNA_101996 delayed tumor growth.Furthermore, we revealed that TET2 regulates MMP2/MMP9 expression through the DNA demethylation pathway. Conclusion:Our findings indicate that hsa_circRNA_101996 promotes GC development by upregulating MMP2/MMP9 through miR-143/TET2 pathway, which may provide a novel target for GC.

Circular RNA

10.7150/jca.62121

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Citations (7)

Photocatalytic degradation of particulate pollutants and self-cleaning performance of TiO2-containing silicate coating and mortar

Construction and Building Materials (2013)

Padmaja Krishnan Min-Hong Zhang Liya E. Yu Huajun Feng

Degradation

Rhodamine B

10.1016/j.conbuildmat.2013.03.009

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Citations (58)

DLTS of ALD HfO₂ on s-Si/SiGe/Si: Effects of s-Si Thickness and Surface Nitridation

ECS Transactions (2009)

Liya E. Yu George George Rozgonyi Pragya R. Shrestha Diefeng Gu Helmut Baumgart

MOS capacitors have been used as depth-dependent probing tools for MOS-DLTS studies of ALD HfO2 on s-Si/SiGe/Si composite samples. Surface nitridation prior to HfO¬2 deposition was carried out to improve the HfO2/s-Si interface by suppressing hafnium silicate interlayer formation. The overall effects of nitridation on the HfO2/s-Si interface and the s-Si/SiGe bulk region with different strained Si layer thicknesses were studied. The relationship between DLTS peak amplitude and pulsing time indicates the emission source in bulk region is related with Ge decorated dislocations and in the interface region it originates from the HfO2/s-Si interface. In the s-Si/SiGe bulk region, nitridation reduces the trap concentration and shifts trap energy level toward mid-gap. For the interface, nitridation shifts trap energy level toward valence band and reduces hole capture cross section significantly.

Silicon-germanium

Hafnium

10.1149/1.3206637

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Citations (1)

Atmospheric chemistry research in Monsoon Asia and Oceania: Current status and future prospects

APN Science Bulletin (2020)

Hiroshi Tanimoto Nguyen Thi Kim Oanh Manish Naja Shih‐Chun Candice Lung Mohd Talib Latif

We aimed to foster the community of atmospheric scientists in the Monsoon Asia and Oceania (MANGO) region to enhance communication among scientists in different countries and strengthen collaborations with the international community, with emphasis on air quality in Asia as it impacts human health and climate change. For this purpose, we have established a regional group, the International Global Atmospheric Chemistry–MANGO (IGAC–MANGO), under the IGAC project sponsored by Future Earth and the international Commission on Atmospheric Chemistry and Global Pollution. Through a series of committee meetings, scientific workshops, and training courses for students and early-career scientists, we analysed scientific activities in each country and identified research priorities in the MANGO region, significantly contributing to enhancing the capability and capacity of air quality research as well as fostering the next generation of scientists in the MANGO region.

10.30852/sb.2020.1246

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Citations (1)

Photocatalytic inactivation of Gram-positive and Gram-negative bacteria using fluorescent light

Journal of Photochemistry and Photobiology A Chemistry (2006)

Amrita Pal Simo O. Pehkonen Liya E. Yu Madhumita B. Ray

Microbacterium

Pseudomonas fluorescens

Gram-Positive Bacteria

10.1016/j.jphotochem.2006.09.002

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Citations (150)

Novel nanocrystalline Ga–Al–Zn complex oxide: catalyst for simultaneous treatment of NPAC and lean NOx

Catalysis Today (2004)

Shali Shen K. Hidajat Liya E. Yu Sibudjing Kawi

Nanocrystalline material

Complex oxide

10.1016/j.cattod.2004.08.014

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Citations (4)

Back Cover: Recombination via point defects and their complexes in solar silicon (Phys. Status Solidi A 10/2012)

physica status solidi (a) (2012)

А. R. Peaker В. П. Маркевич B. Hamilton Gábor Paráda Alan Dudas

The back-cover image, taken from the Feature Article by A. R. Peaker et al. (pp. 1884–1893), depicts a map of the minority carrier lifetime of an inexpensive form of silicon used to manufacture solar photovoltaic cells. The silicon is cast from relatively impure feedstock and is much cheaper than electronic grade silicon grown by conventional Czochralski or float zone methods. However, the minority carrier lifetime and hence the efficiency of solar cells made from it are considerably less than electronic grade. The picture shows the variation of lifetime between grains represented by a spectrum of colours (red relates to a short lifetime while blue indicates the longest lifetime). It can be seen that variations occur across the material not necessarily related to the grain boundaries. Maps such as this, used in conjunction with other techniques, can enable the lifetime to be correlated with specific defects and recombination processes and, in favourable circumstances, enable much higher efficiencies to be achieved.

Carrier lifetime

10.1002/pssa.201290026

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Smoke radiocarbon measurements from Indonesian fires provide evidence for burning of millennia-aged peat

Proceedings of the National Academy of Sciences (2018)

Elizabeth B. Wiggins C. I. Czimczik Guaciara M. Santos Yang Chen Xiaomei Xu

Significance We report radiocarbon ( 14 C) measurements of carbonaceous aerosol originating from fires on the islands of Sumatra and Borneo. These data provide information about what types of ecosystems burned and are critical for linking the human health effects of fires to the anthropogenic build-up of atmospheric CO 2 . Our measurements confirm that peat emissions were the dominant source of aerosols in Singapore during the 2015 El Niño and provide a means for monitoring the success of policies designed to protect peatland areas during future drought events.

10.1073/pnas.1806003115

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Citations (68)

Design of high efficiency PVDF-PEG hollow fibers for air filtration of ultrafine particles

Journal of Membrane Science (2017)

Ling-Yi Wang Wai Fen Yong Liya E. Yu Tai‐Shung Chung

Permeance

Filtration (mathematics)

Polyvinylidene fluoride

10.1016/j.memsci.2017.04.053

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Citations (78)

Nitration of polynuclear aromatic hydrocarbons in coal combustors and exhaust streams. Quarterly report, January 1, 1994--March 31, 1994

Liya E. Yu Sung Hwan Cho Lynn M. Hildemann Stephen Niksa

Activity during this quarter on the sample preparation side extended our capabilities to perform experiments on the oxidative pyrolysis of coal volatiles. Previously, our experiments characterized primary devolatilization and secondary volatiles pyrolysis. Now we are almost ready to report complete product distributions and to prepare PAH samples for controlled extents of oxidative pyrolysis at various oxygen levels. Tests addressed the issue of soot formation in the presence of oxygen. Our preliminary results indicate that significant amounts of the aerosol product is converted into gases before all the tar is converted into soot. Accordingly, total aerosol yields (as sum of tar plus soot) are lower than their levels after secondary pyrolysis while soot fractions (of the total aerosol product) are much less than unity. Preliminary determinations of the noncondensible gases show an abundance of CO{sub 2} and H{sub 2}O with substantial amounts of CO and H{sub 2} plus trace levels of CH{sub 4}, C{sub 2}H{sub 2}, and C{sub 2}H{sub 4}. However, only the elemental balance on oxygen is closed within acceptable tolerances, pending further characterization of tar, soot, and char compositions. Nitrogen species were not monitored at this stage. The final methodology for separating PAH via high-pressure liquid chromatography was selected. The accuracy of this approach for determining the ring number distribution of the PAH in the fractionated coal tar was evaluated using a range of PAH standards. It was determined that even slightly-polar substituents greatly retard the elution time of the parent PAH, to beyond the 6-ring compounds. Thus, the ring number distribution can be accurately determined for nonpolar PAH of 2 to 5 rings. Evaluation of relative response factors for each of these ring sizes has been completed.

tar (computing)

Coal tar

10.2172/10162252

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