An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
A Monte Carlo mathematical model is developed to simulate the atomic oxygen undercutting interaction between atomic oxygen and polyimide film. The physical undercutting processes are described by tracing transportation particle approach on the basis of the statistical mechanics. Under the 43 degree and 28.5 degree orbit angle of spacecraft, predicted results are carried out by numerical simulation technique and the affecting factors are discussed in detail. Undercutting with breaker patterns are in good agreement with flight experimental data. Larger atomic oxygen fluence is favorable for producing the bigger undercutting depth and width. The maximum undercutting depth is always larger than maximum undercutting width. Mass loss increased with the increment of initial impact reaction probability and the decrease thermal assimilation coefficient. With respect to the bigger orbit angle, the difference between depth and width are reduced due to the decreasing depth and the increasing width.
Complex of 18\|crown\|6 with K 2[Pd(NO 2) 4]has been isolated and characterized by IR and X\|ray diffraction analysis.The crystal structure belongs to monoclinic,space group P2 1/c with cell dimensions,a= 1.710 4(3) ,b=1.485 9(3),c=1.576 3(3) nm,β=93.49(3) 0,V=3.998 7(14) nm 3,Z=4,F(000)=1 880,In the solid state,the complex contains two groups [K(18C6)] 2[Pd(NO 2) 4](1) and [K(18C6)] 2[Pd(NO 2) 4](H 2O)(2).The later displays an one\|dimensional infinite chain of two [K(18C6)] + complex cations and a [Pd(NO 2) 4] 2- anion bridged by one H 2O molecule between adjacent [K(18C6)] + units.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Abstract A series of Sm‐doped Ca 2 Sb 2 O 7 samples is prepared by solid state reaction of CaCO 3 , Sb 2 O 3 , and Sm 2 O 3 (air, alumina crucible, 1150 °C, 16 h).
Stratum corneum (SC) is the most superficial skin layer. Its contact with the external environment means that this tissue layer is subjected to both cleansing agents and daily variations in ambient moisture; both of which can alter the water content of the tissue. Reductions in water content from severe barrier dysfunction or low humidity environments can alter SC stiffness and cause a build-up of drying stresses. In extreme conditions, these factors can cause mechanical rupture of the tissue. We have established a high throughput method of quantifying dynamic changes in the mechanical properties of SC upon drying. This technique can be employed to quantify changes in the drying behavior and mechanical properties of SC with cosmetic cleanser and moisturizer treatments. This is achieved by measuring dynamic variations in spatially resolved in-plane drying displacements of circular tissue samples adhered to an elastomer substrate. In-plane radial displacements acquired during drying are azimuthally averaged and fitted with a profile based on a linear elastic contractility model. Dynamic changes in drying stress and SC elastic modulus can then be extracted from the fitted model profiles.
Ulcerative colitis (UC) is an inflammatory disease of the colon that is characterized by mucosal ulcers. Given its increasing prevalence worldwide, it is imperative to develop safe and effective drugs for treating UC. Emodin, a natural anthraquinone derivative present in various medicinal herbs, has demonstrated therapeutic effects against UC. However, low bioavailability due to poor water solubility limits its clinical applications.Emodin-borate nanoparticles (EmB) were synthesized to improve drug solubility, and they modified with oligomeric mannitol into microgels (EmB-MO) for targeted delivery to intestinal macrophages that express mannose receptors. UC was induced in a mouse model using dextran sulfate sodium (DSS), and different drug formulations were administered to the mice via drinking water. The levels of inflammation-related factors in the colon tissues and fecal matter were measured using enzyme-linked immunosorbent assay. Intestinal permeability was evaluated using fluorescein isothiocyanate dextran. HE staining, in vivo imaging, real-time PCR, and western blotting were performed to assess intestinal barrier dysfunction.Both EmB and EmB-MO markedly alleviated the symptoms of UC, including body weight loss, stool inconsistency, and bloody stools and restored the levels of pro- and anti-inflammatory cytokines. However, the therapeutic effects of EmB-MO on the macroscopic and immunological indices were stronger than those of EmB and similar to those of 5-aminosalicylic acid. Furthermore, EmB-MO selectively accumulated in the inflamed colon epithelium and restored the levels of the gut barrier proteins such as ZO-1 and Occludin.EmB-MO encapsulation significantly improved water solubility, which translated to greater therapeutic effects on the immune balance and gut barrier function in mice with DSS-induced UC. Our findings provide novel insights into developing emodin-derived drugs for the management of UC.
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