Hsing-Han Li

University of California, San Diego

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Omar S. Akbari

University of California, San Diego

Shih-Cheng Wu

National Taiwan University

Wan-Tin Tsai

National Institute of Infectious Diseases

Chao-Ying Pan

National Kaohsiung Normal University

John M. Marshall

University of California, Berkeley

Guann‐Yi Yu

National Health Research Institutes

Matthew P. Su

Nagoya University

Prasad N. Paradkar

Australian Centre for Disease Preparedness

Igor Antoshechkin

California Institute of Technology

Sarah Jackson

Australian Centre for Disease Preparedness

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National Health Research Institutes

University of California, San Diego

Commonwealth Scientific and Industrial Research Organisation

CSIRO Health and Biosecurity

University of York

University of California, Berkeley

National Taiwan University

National Institute of Infectious Diseases

Australian Centre for Disease Preparedness

Universidad Católica Santo Domingo

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Mechanical transmission of Dengue Virus byAedes aegyptimay influence disease transmission dynamics during outbreaks

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Hsing-Han Li Matthew P. Su Shih-Cheng Wu Hsiao‐Hui Tsou Meng-Chun Chang

Abstract The escalating number of dengue virus (DENV) outbreaks and their worldwide spread pose a major threat to global public health. DENV transmission dynamics significantly influence outbreak duration and magnitude. Conventional DENV transmission requires an incubation period between mosquitoes biting infected humans and the mosquitoes becoming infectious. However, the possibility of immediate, mechanical transmission of DENV without viral replication in the mosquito has received little attention despite its potential importance. Here, we show that Aedes aegypti mosquitoes can mechanically transmit DENV to susceptible mice immediately after biting infected mice without the need for an incubation period. By incorporating parameters from our experiments into a newly developed mathematical model, we found a significant impact on DENV outbreak characteristics. Mechanical transmission may amplify existing disease transmission routes and influence outbreak dynamics. Our findings have implications for vector control strategies that target mosquito lifespan and suggest the possibility of similar mechanical transmission routes in other disease-carrying mosquitoes.

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10.1101/2023.03.07.531453

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Citations (2)

Engineered Antiviral Sensor Targets Infected Mosquitoes

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Elena Dalla Benetta Adam J. López-Denman Hsing-Han Li Reem A. Masri Daniel J. Brogan

Escalating vector disease burdens pose significant global health risks, so innovative tools for targeting mosquitoes are critical. We engineered an antiviral strategy termed REAPER (v

10.1101/2023.01.27.525922

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Citations (8)