Ping-Qing Wang

Chongqing University

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Baoyun Zhang

Northwestern Polytechnical University

Mingxing Chu

Chinese Academy of Agricultural Sciences

Q. Fan

Southeast University

Ping Lai

Nanjing University of Science and Technology

Ying Tan

Nankai University

Chong-Xu Liu

Chongqing University

Lang Lu

Janssen (United States)

Ran Di

Chinese Academy of Agricultural Sciences

Ping Chin Lai

Longyan University

Wei Xiang

Renji Hospital

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Chongqing University

Nanjing University of Science and Technology

Xiangya Hospital Central South University

Central South University

Chinese Academy of Agricultural Sciences

Ministry of Agriculture and Rural Affairs

Institute of Animal Science

Xiamen University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

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Effects of RFRP-3 on reproductive function and energy balance in mammals

Hereditas (Beijing) (2012)

Wei Xiang Ping Lai Baoyun Zhang Ping-Qing Wang Mingxing Chu

The hypothalamo-pituitary-gonadal (HPG) axis integrates internal and external cues via a balance of stimulatory and inhibitory neurochemical systems to regulate reproductive function in mammals. However, RFRP-3 is a unique inhibitor of HPG axis at the hypothalamuic level in mammals to date. A large number of previous studies have confirmed that RFamide-related peptide (RFRP-3) suppresses gonadotropin-releasing hormone (GnRH) system and luteinizing hormone (LH) secretion, thereby affecting the reproduction. However, whether the inhibition of LH secretion by RFRP-3 occurs at the pituitary level or the hypothalamus level is not clear. It is interesting that RFRP-3 is also related to signal pathway of melatonin modulating mammal seasonal reproduction, but little is known about the effects of melatonin on the RFRP-3 neuron up to now. In addition, RFRP-3 also plays an important role in the regulation of energy balance and behavior. The regulatory mechanism of RFRP-3 in HPG axis and role of RFRP-3 in modulating mammalian energy balance, as well as behavior, are systematically elaborated and the remaining unsolved problems are also discussed in this paper.

Neurochemical

10.3724/sp.j.1005.2012.00969

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Progesterone receptor-mediated molecular mechanisms on mam-malian female reproduction

Hereditas (Beijing) (2012)

Yuehua Kang Baoyun Zhang Ping-Qing Wang Mingxing Chu Ping Chin Lai

The steroid hormone, progesterone, plays a critical role in regulation of mammalian female reproductive activities.Besides the non-genomic activity of progesterone on target cells, its main physiological effect is caused through genomic action by the ligand-dependent nuclear progesterone receptor.The genomic and non-genomic effects of progesterone collectively mediate various female reproductive functions, including ovulation, embryo implantation, maintenance of pregnancy, initiation of parturition, and development of mammary gland.Although a large number of candidate genes regulated by progesterone have been identified by gene chip technology, the traditional progesterone response elements located in the promoter region of downstream target genes havenot been detected.Accordingly, it was suggested thatthe mechanism of nuclear progesterone receptors regulating transcription may be different from other nuclear steroid receptors.In this review, we summarized the mechanisms of progesterone receptors mediating the physiological effects in various female re-1224 HEREDITAS (Beijing) 2012 第 34 卷 productive activities.

Progesterone receptor

Steroid hormone

Steroid hormone receptor

10.3724/sp.j.1005.2012.01223

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Advances on progesterone receptor gene

Hereditas (Beijing) (2009)

Baoyun Zhang Ran Di Mingxing Chu Ping-Qing Wang Lang Lu

The steroid hormone, progesterone, plays a key role in diverse events associated with female reproduction. In humans and other vertebrates, the biological activity of progesterone is mediated by modulation of the transcriptional activity of two progesterone receptors, PGR-A and PGR-B. This review introduced the structure, expression regulation and polymorphism of progesterone receptor gene. The relationship between progesterone receptor gene and reproductive function was also discussed in mammals.

Progesterone receptor

Steroid hormone

10.3724/sp.j.1005.2008.01536

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The neuroendocrine regulatory mechanisms of mammalian seasonal reproduction

Hereditas (Beijing) (2012)

Ping Lai Ping-Qing Wang Baoyun Zhang Mingxing Chu Chong-Xu Liu

The seasonal reproduction of mammal means the reproduction experiences an annual period from quiescence to renaissance. Studies have shown that kisspeptin and RFRP play an important role in the reproductive seasonality. The non-breeding season is characterized by an increase in the negative feedback effect of estrogen on GnRH, and this effect is transmitted by kisspeptin neurons, which may be an important factor affecting the reproduction activities. The expression of RFRP depends on melatonin secretion, and shows an apparent inhibition on reproduction in non-breeding season. In addition, thyroid hormones influence termination of the breeding season. Dopaminergic neuron A14/A15 also contributes to the seasonal changes in estrogen negative feedback. These neural systems may synergistically modulate the seasonal changes of reproductive function with the photoperiod. This review makes a systematic expatiation on the relationship between seasonal reproduction and these neural systems.

Kisspeptin

10.3724/sp.j.1005.2012.00281

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Citations (3)