Chi Him Eddie

City University of Hong Kong

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Ngan Pan Bennett Au

City University of Hong Kong

Gajendra Kumar

Brown University

Pallavi Asthana

Hong Kong Baptist University

Clifford J. Woolf

Boston Children's Hospital

Shu-Yen Wan

Chang Gung University

Yim Ling Mak

City University of Hong Kong

Leo Lai Chan

City University of Hong Kong

Chand Raza

Government College University, Lahore

Giovanni Coppola

University of California, Los Angeles

Raymond Chuen‐Chung Chang

University of Hong Kong

Cooperative Institutions

City University of Hong Kong

Harvard University

University of Hong Kong

Boston Children's Hospital

Chinese University of Hong Kong

Massachusetts Eye and Ear Infirmary

Chang Gung University

Smith-Kettlewell Eye Research Institute

City University of Hong Kong, Shenzhen Research Institute

Chinese Academy of Sciences

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Artificial intelligence (AI) and machine learning (ML) based encephalogram (EEG) platform for drug’s screening

G V S Phani Kumar Chi Him Eddie

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A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(ii) probe for in vivo imaging of live neurons

Chemical Communications (2014)

Yu‐Man Ho Ngan Pan Bennett Au Ka‐Leung Wong Chris Tsz‐Leung Chan Wai‐Ming Kwok

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}(2+) (1) and {[Pt(L2)]2(μ-dppm)}(2+) (2), as lysosome-specific two-photon imaging probes.

Dorsal root ganglion

Two-photon excitation microscopy

10.1039/c3cc48934e

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Citations (40)

Osteonectin is a Schwann cell‐secreted factor that promotes retinal ganglion cell survival and process outgrowth

European Journal of Neuroscience (2005)

Edward T. W. Bampton Chi Him Eddie Aviva M. Tolkovsky J. S. H. Taylor

Abstract We have investigated the factors made by Schwann cells (SCs) that stimulate survival and neurite outgrowth from postnatal rat retinal ganglion cells (RGCs). These effects are preserved under K252a blockade of the Trk family of neurotrophin receptors and are not fully mimicked by the action of a number of known trophic factors. To identify novel factors responsible for this regenerative activity, we have used a radiolabelling assay. Proteins made by SCs were labelled radioactively and then fed to purified RGCs. The proteins taken up by the RGCs were then isolated and further characterized. Using this assay we have identified a major 40 kDa factor taken up by RGCs, which was microsequenced and shown to be the matricellular protein osteonectin (ON). Using an in vitro assay of purified RGCs we show that ON promotes both survival and neurite outgrowth. We conclude that ON has a potential new role in promoting CNS repair.

Neurite

Osteonectin

Matricellular protein

10.1111/j.1460-9568.2005.04128.x

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Citations (35)

Neurometabolomic Profiling of neurotransmitters after repeated exposure of Pacific ciguatoxin-1

Neuroscience (2015)

Chi Him Eddie Nga Yu Elva Lei Ngan Pan Bennett Au Gajendra Kumar Yim Ling Mak

Ciguatoxin

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Overexpression of basic helix-loop-helix protein promotes axon regeneration after nervous system injuries

Gajendra Kumar Ngan Pan Bennett Au Sung-Kay Chiu DH Geschwind G. Coppola

Helix (gastropod)

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Low-dose ionizing radiation promotes motor recovery and brain rewiring by resolving inflammatory response after brain injury and stroke

Brain Behavior and Immunity (2023)

Ngan Pan Bennett Au Tan Wu Gajendra Kumar Yuting Jin Yolanda Y. T. Li

Stroke

10.1016/j.bbi.2023.09.015

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Connectivity preserving transformation of digital images: theory and applications

Chi Him Eddie

Thinning is a preprocessing operation of pattern recognition that erodes an object layer by layer until only a unit width skeleton is left. A thinning algorithm must connectivity, that is, for every possible input image, its output image has the same connectivity structure. Many thinning algorithms for 2D images have been proposed. But this is not the case for 3D images. Our first objective is to design two 3D fully parallel thinning algorithms--one for generating skeletons as medial faces and the other one for medial lines. A multimedia team at M.I.T. is interested in the medial-face algorithm for analyzing actions of baseball players in 3D images (length $\times$ width $\times$ time). The medial-line algorithm is applied to 3D medical images at the University of Iowa. The images (length $\times$ width $\times$ depth) show bronchial trees in human lungs. The resulting images after the application of our algorithm can be used eventually ta save lives. Since there are infinitely many images, it is difficult to show that a thinning algorithm preserves connectivity for all input images. Ronse proposed a solution to this problem for 2D images. Our second objective is to establish connectivity preservation tests for 3D thinning algorithms such that whether a 3D thinning algorithm does or does not preserve connectivity can be determined efficiently and systematically. Since both Ronse's 2D results and our 3D results only need to check a finite number of configurations, we can use computers to give such proofs automatically. Kong et al. established such a 2D program using a small look-up table for testing the connectivity preservation of any thinning algorithm. Our third objective is to establish computerized tests using 3D look-up tables to verify the connectivity preservation of 3D thinning algorithms. A thinning algorithm is a set of deleting templates. We use a look-up table to test the connectivity preservation of each template. A complete 3D look-up table is about 318 GBytes which is not feasible. Thus, our last objective is to establish a memory efficient algorithm for establishing such a 3D look-up table of a feasible size.

Thinning

Medial axis

Line (geometry)

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Extracting medial curves on 3D images

Pattern Recognition Letters (2002)

Chi Him Eddie Shu-Yen Wan Her-Kun Chang

Soundness

Thinning

10.1016/s0167-8655(01)00162-3

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Citations (19)

APPLYING UML TO THE DEVELOPMENT OF MEDICAL CARE PROCESS MANAGEMENT SYSTEM FOR NURSING HOME RESIDENTS

Int. J. Electron. Bus. Manag. (2005)

Yeh‐Chun Juan Chi Him Eddie Huang-Mu Chen

Taiwan has been recognized by World Health Organization (WHO) as an “elderly” country in 1993 since its elderly (65 or older) population ratio was over 7%. Due to the physiological and psychological degeneration, the elderly always has a higher possibility of suffering from chronic diseases. Chronic patients, including the elderly suffering from chronic diseases, have burdened their families with the long-term medical-care need. Until recently, the emergence of nursing homes has successfully alleviated the heavy burden on chronic patients’ families. A nursing home provides various professional medical-care services to its residents (i.e., patients of the nursing home) by doctors, nursing specialists, nurses, rehabilitation doctors, social workers, and occupational therapists. Each resident is indeed a unique case to a nursing home. As a result, the medical-care process management has become one of the most important factors for improving the medical care quality of a nursing home. This research took the Chang-Gung Nursing Home as an example and applied Unified Modeling Language (UML) to analyze corresponding medical care processes. A medical care process management system was developed and implemented for the Chang-Gung Nursing Home.

Population Ageing

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A small heat shock protein protects against Guillain-Barré syndrome in mice

Pallavi Asthana Gajendra Kumar Gang Zhang Kazim A. Sheikh Chi Him Eddie

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