GÁ

Gema Álvarez‐García

Universidad Complutense de Madrid

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Luís Miguel Ortega-Mora

Universidad Complutense de Madrid

112

Javier Regidor‐Cerrillo

Universidad Complutense de Madrid

Daniel Gutiérrez-Expósito

Hospital Dipreca

Adriana Aguado-Martínez

University of Bern

Paula García-Lunar

Universidad Complutense de Madrid

Carlos Diezma‐Díaz

Universidad Complutense de Madrid

Esther Collantes-Fernández

Universidad Complutense de Madrid

Alejandro Jiménez‐Meléndez

Norwegian University of Life Sciences

Gereon Schares

Friedrich-Loeffler-Institut

Ignacio Ferre

Universidad Complutense de Madrid

Cooperative Institutions

Universidad Complutense de Madrid

173

Cambridge University Press

Instituto de Salud Carlos III

Consejo Superior de Investigaciones Científicas

Universidad de Zaragoza

Institute of Parasitology

National Agricultural Technology Institute

Consejo Nacional de Investigaciones Científicas y Técnicas

Département Santé Animale

University of Washington

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PAR volume 140 issue 5 Cover and Back matter

Parasitology (2013)

Xiaohong Huang Yang Xu Guowei Guo Qianqian Lin Zhongfeng Ye

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Content (measure theory)

10.1017/s0031182013000280

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Identificación de proteínas Neospora caninum implicadas en procesos de invasión y virulencia

Proteómica: revista de la Sociedad Española de Proteómica (2010)

Virginia Marugán‐Hernández Javier Regidor‐Cerrillo Gema Álvarez‐García Fiona M. Tomley Adriana Aguado-Martínez

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Resveratrol protects pancreatic beta cell and hippocampal cells from the aggregate-prone capacity of hIAPP

Scientific Reports (2024)

Carlos González-Blanco Ángela Cristina Lockwood Beatriz Jiménez Sarai Iglesias-Fortes Patricia Marqués

Type 2 diabetes mellitus and Alzheimer's disease, are two closely related pathological situations that are connected at the molecular level. In recent years, amylin, which is co-secreted with insulin, has been proposed for being a main actor in this context due to its capacity to form aggregates in a β-sheet-like structure. In a diabetic milieu, there is an increase in the production and secretion of insulin and amylin. We have analysed the role of resveratrol on aggregate formation and in the production of extracellular vesicles with amylin in its interior and in pancreatic β cells overexpressing human amylin (INS1E-hIAPP). Furthermore, we have explored the consequences of the exposition of the conditioned medium derived from INS1E-hIAPP in the hippocampal cell line HT-22 and the role of resveratrol in this cell line. Hippocampal cells were exposed to conditioned media obtained from rat insulinoma 1E overexpressing human amylin in the presence or in the absence of resveratrol. When we exposed HT-22 cells to the conditioned media of INS1E-hIAPP we observed amylin-aggregates inside HT-22 cells. Resveratrol was able to alleviate this effect not only in HT-22 but also in pancreatic β cells. Furthermore, resveratrol decreased the average exosome size produced by the INS1E-hIAPP stimulated with high glucose, diminishing the toxic effect of these exosomes in HT-22 cells. We have uncovered that resveratrol inhibits the aggregation capacity of amylin and it can diminish the deleterious spreading of the toxic protein, to other cell types such as the hippocampal neuron cells, HT-22.

BETA (programming language)

10.1038/s41598-024-78967-2

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Neospora caninum infection in breeder bulls: seroprevalence and comparison of serological methods used for diagnosis

Veterinary Parasitology (2004)

Andrea Caetano-da-Silva Ignacio Ferre Gorka Adúriz Gema Álvarez‐García I. del-Pozo

Seroprevalence

Neospora

10.1016/j.vetpar.2004.06.023

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Citations (19)

Cell immortalization facilitates prelamin A clearance by increasing both cell proliferation and autophagic flux

Aging (2022)

Carlos González-Blanco Patricia Marqués Jesús Burillo Beatriz Jiménez Gema Álvarez‐García

Hutchinson-Gilford Progeria Syndrome is an ultrarare disease which is characterized by an accelerated senescence phenotype with deleterious consequences to people suffering this pathology. The production of an abnormal protein derived from lamin A, called progerin, presents a farnesylated domain, which is not eliminated by the causal mutation of the disease, and accumulates in the interior of the nucleus, provoking a disruption of nuclear membrane, chromatin organization and an altered gene expression. The mutation in these patients occurs in a single nucleotide change, which creates a de novo splicing site, producing a shorter version of the protein. Apart from this mutation, an alteration in the metalloproteinase Zmpste24, involved in the maturation of lamin A, causing a similar alteration than in progeria. However, in this case, patients accumulate a protein, called prelamin A, which generates similar alterations in the nucleus than progerin. The reduction of prelamin A protein levels facilitates the recovery of the phenotype in different mice models of the disease, reducing the aging process. Different strategies have been studied for eliminating this toxic protein. Here, we report that immortalization of primary cells derived from the Zmpste24 KO mice, facilitates prelamin A degradation by different mechanisms, being essential, the enhancing proliferative capacity that the immortalized cells present. Then, these data suggest that using different treatments for increasing proliferative capacity of these cells, potentially could have a beneficial effect, facilitating prelamin A toxicity.

Progeria

Nuclear lamina

LMNA

10.18632/aging.203943

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An inter-laboratory comparative study of serological tools employed in the diagnosis of Besnoitia besnoiti infection in bovines

HAL (Le Centre pour la Communication Scientifique Directe) (2011)

P. Garcia Lunar Luis Miguel Ortega Mora G. Schares Philippe Jacquiet Christelle Grisez

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