The secretion of fluid and electrolytes, as well as amylase, was studied in response to secretin and pancreozymin stimulation in unanesthetized dogs fitted with a Thomas-type duodenal fistula by inserting a cannula directly into the main pancreatic duct before and during a 3-week period of ethionine administration. In addition to the well-established destructive effect of d-l-ethionine on the acinar cell and its secretion of enzymes, changes occurred in the secretion of HCO 3 and H 2 O in response to secretin. During the early phase of ethionine intoxication (weeks 1–2) HCO 3 concentration fell despite preservation of the volume rate of flow. During the second and third weeks, HCO 3 concentration was preserved despite marked reduction in volume rate of flow. It is suggested that these findings may be correlated with changes in ductular as well as acinar cells. Na and K concentration, juice osmolality, and the reciprocal Cl-HCO 3 relationship were unaltered.
A multinodular parotid tumor in a 63-year-old man occupied almost the entire gland and was found to represent diffuse oncocytic growth. The literature on salivary gland oncocytoma is reviewed. This case appears to be a unique example of diffuse proliferation of oxyphilic granular cells (oncocytes) virtually replacing the normal parotid acinar structure. There was no evidence of local or distant spread.
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