Murray Oratz

New York University

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Marcus A. Rothschild

John Wiley & Sons (United States)

Sidney S. Schreiber

University Medical Center

S. S. Schreiber

Rancho Los Amigos National Rehabilitation Center

Rothschild Ma

Freie Universität Berlin

Joseph Mongelli

New York University

SS Schreiber

Schreiber Ss

UES (United States)

Carole Evans

Valeo (France)

Shaul Schreiber

Tel Aviv Sourasky Medical Center

C D Evans

Eli Lilly (United States)

Cooperative Institutions

New York University

United States Department of Veterans Affairs

Columbia University Irving Medical Center

University Medical Center

Icahn School of Medicine at Mount Sinai

Harvard University

UiT The Arctic University of Norway

State University of New York

Albert Einstein College of Medicine

Mount Sinai Beth Israel

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Alcohol Inhibition of Protein Synthesis

Clinical toxicology (1975)

Marcus A. Rothschild Sidney S. Schreiber Murray Oratz

(1975). Alcohol Inhibition of Protein Synthesis. Clinical Toxicology: Vol. 8, No. 3, pp. 349-357.

Clinical toxicology

10.3109/15563657508988084

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Citations (5)

Protein secretion in suspensions of isolated rat hepatocytes: No influence of acute ethanol administration

Gastroenterology (1981)

Jørg Mørland Marcus A. Rothschild Murray Oratz Joseph Mongelli D. Donor

Trypan blue

Colchicine

Bovine serum albumin

10.1016/0016-5085(81)90207-9

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Citations (37)

Effects of ischemia & ethanol on synthesis of cardiac collagen & myoglobin in pressure loaded right ventricles

Journal of Molecular and Cellular Cardiology (1984)

Shaul Schreiber Murray Oratz Marcus A. Rothschild

Cardiac ischemia

Cardiac Ventricle

10.1016/s0022-2828(84)80513-1

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Citations (2)

Prolonged Feeding of Ethanol to the Young Growing Guinea Pig: 1, The Effect on Protein Synthesis in the Afterloaded Right Ventricle Measured in Vitro

Alcoholism Clinical and Experimental Research (1982)

Sidney S. Schreiber Carole Evans Francine Reff Marcus A. Rothschild Murray Oratz

Newly weaned guinea pigs weighing approximately 300 g were fed normal laboratory diets with drinking water containing 5.5% ethanol as the sole source of liquid for periods of 8–11 weeks. Growth was continuous with this diet. After this period, hearts were removed from anesthetized animals and perfused for 3 hr in a perfusion system in which pressure may be induced in the right ventricle In the face of constant coronary flow. Protein synthesis, assayed from the incorporation of labeled lysine and phenylalanine, was compared to that in hearts from identically treated weight‐matched control animals who had been drinking water without ethanol. Protein synthesis in hearts from ethanoWrinking animals was decreased in the right ventricles exposed to normal pulmonary pressure, but was unchanged in the contracting but not working left ventricles. The data suggest that prolonged exposure even to low levels of ethanol in the growing animal may interfere with the cardiac protein synthetic response to the normal work stress.

10.1111/j.1530-0277.1982.tb04996.x

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Citations (26)

Spermine stimulation of CCl4 depressed protein synthesis in rabbits

Gastroenterology (1980)

Murray Oratz Marcus A. Rothschild Sidney S. Schreiber Bernard Lane

Polysome

Secretory protein

10.1016/0016-5085(80)90909-9

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Citations (16)

Regulation of albumin synthesis

Springer eBooks (1978)

Murray Oratz Marcus A. Rothschild S. S. Schreiber

Peptide bond

Proteolysis

Pentapeptide repeat

Serum Albumin

Moiety

10.1007/978-94-009-9744-8_5

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Citations (0)

ALBUMIN SYNTHESIS††Supported in part by the U.S. Public Health Service Grants AA 00959 and HL 09562.

Elsevier eBooks (1977)

Marcus A. Rothschild Murray Oratz Sidney S. Schreiber

Serum Albumin

10.1016/b978-0-08-019603-9.50017-x

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Citations (6)

Synthesis of myosin heavy and light chains in the afterloaded guinea pig right ventricle

Cardiovascular Research (1978)

Ceryn Evans S. S. Schreiber Murray Oratz Marcus A. Rothschild

Increased afterload causes increased cardiac myosin synthesis and ultimately leads to hypertrophy. Since the latter is associated with altered myosin ATPase activity, it was of interest to study the synthesis of myosin subunits in the acute response to this stress. An in vitro guinea pig heart preparation was used which allowed application of afterload to the right ventricle with unaltered coronary flow, and also permitted measurement of synthesis of myosin heavy chains (HC) and combined light chains (LC) by continuous perfusion with labelled amino acids (3H-lysine and/or 3H-phenylalanine) of constant specific activity. Isolation of 3H-labelled HC and LC with heterologous unlabelled carrier was possible because of identical mobilities of HC's and LC's from unlabeled lamb carrier myosin and 3H-labelled guinea pig myosin. This permitted study of comparative synthesis of the HC and LC in small samples as the single guinea pig right ventricle (100-150 mg) and avoided errors inherent in pooling hearts or in measurement of turnover in the non-steady state. After 3 h of perfusion, the ratio of synthesis of HC/LC was 2 : 1 in controls. This ratio increased significantly to 3 : 1 in afterload. It is possible that the disproportionate increase in HC synthesis may lead to stoichiometric problems in myosin assembly which ultimately effect altered myosin ATPase activity.

Afterload

10.1093/cvr/12.12.731

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Citations (14)

Alcoholic cardiomyopathy: Studies of protein metabolism

Journal of Molecular and Cellular Cardiology (1986)

Shaul Schreiber Marcus A. Rothschild Murray Oratz

Alcoholic cardiomyopathy

10.1016/s0022-2828(86)80218-8

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Citations (0)

Effects of Ethanol on Protein Synthesisa