Sodium hydroxide was used as catalyst and N-acetylcaprolactam was used as activator. The amount-of-substance ratio of catalyst as well as activator to comonomer was 1∶400. The initial temperature of the copolymerization was 130℃. The copolymer of toughening MC nylon can be prepared by activated anionic copolymerization under the adiabatic condition. The melting point values and crystalline phase content of copolymers were established from DSC measurements. The shape of endothermic melting peak in the DSC curve can suggest that random copolymer is formed. The decrease of the crystallinity is caused by influence of the copolymerization. The crystallites are characterized by a wide distribution of melting points, irregularly developed, and disturbed by high content of amorphous chains.
To investigate therapeutic effects of arthroscopic treatment for acute patellar dislocation.From May 2002 to March 2009, 36 patients with acute patellar dislocation were treated with arthroscopy, including taking out of the free cartilage chips, relaxing lateral retinaculum and tight suturing medial retinaculum. Among the patients, 6 patients were males and 30 patients were females, ranging in age from 12 to 30 years (averaged, 20.5 years). Fifteen patients had the dislocations on the left an 21 patients had the dislocations on the right. The development of condyles of femur and Q trianglel were detected by preoperative radiology. The Lysholm criteria system was used to evaluate the clinical effects.All the patients were followed up, and the duration ranged from 13 to 60 months (averaged, 42 months). All the patients had no complications such as infection, and the knee range of motion recovered to normal without pain. The Lysholm score improved from preoperative (28.9 +/- 2.5) to postoperative (95.1 +/- 8.4). All the patients had no redislocation.Acute dislocation of the patella is an potential devastating injury. The arthroscopic treatment for acute patellar dislocation has advantages such as less trauma, faster recovery and more reliable.
Objective:To investigate the effect of left thorax and right thorax operating ways on cardiovascular function in patients with esophageal carcinoma.Methods:A total of 128 patients with esophageal carcinoma were divided to two groups randomly,one was left thorax operation group (n= 67),the other was right thorax operation group(n=61).The hemodynamic indexes and cardiac function were detected with color ultrasonic cardiogram before and after operation.The clinical data and cardiovascular complications were evaluated after operation.Results:The cardiovascular complications(20.9% vs.3.3%),SBP[(132.6±27.9)mmHg vs.(116.8±14.3)mmHg]、HR [(118.6±26.4)beats/min vs.(87.7±19.2) beats/min]and MAP [(84.6±13.8)mmHg vs.(61.2±11.6)mmHg] of left thorax operation group were significantly higher than those of right thorax operation group respectively(P0.05～0.01).The LVEDV[(70.2±25.3)ml vs.(87.6±27.8) ml]、LVESV[(30.1±12.4)ml vs.(39.5±23.6)ml]、LAEDV[(28.7±13.5)ml vs.(45.7±15.2) ml]、 LAESV[(25.1±11.7)ml vs.(31.4±12.6)ml]、LVEF [(47.2±15.7)% vs.(64.3±13.6)%] and LAEF [(33.5±18.4) % vs.(53.2±15.9)%] of left thorax operation group were significantly lower than those of right thorax operation group respectively(P0.05～0.01).The RAEDV[(45.8±11.6) ml vs.(37.3±14.5)ml]、RAESV[(30.3±9.1)ml vs.(26.8±13.2)ml]、RAEF [(50.3±11.5)% vs.(38.6±13.1)% ] of left thorax operation group were significantly higher than those of right thorax operation group respectively(P0.05～0.01).Conclusion:It would be much better to choose the operation pattern by right chest than by left chest operation for esophageal carcinoma patients,especially with poor heart and lung function.
Ni-Sn-P alloy plating samples with different Sn content are prepared.The main compositions of the plating are studied by the spectrometer,and the anticorrosion properties are investigated respectively.The results showed that the anticorrosion property of Ni-Sn-P alloy plating increases with the Sn content.
To investigate the therapeutic effect of lateral rectus abdominis incision combined with winged calcaneal plate on pelvic and acetabular fractures involving quadrilateral body.From January 2017 to April 2021, 21 cases of pelvic and acetabular fractures involving quadrilateral bodies were retrospectively analyzed, including 12 males and 9 females. The age ranged from 21 to 73 years with an average of (43.23±6.45) years. All patients were treated by lateral incision of rectus abdominis combined with open reduction and internal fixation with aerofoil plate, including 12 cases of pelvis with anterior and posterior column fractures, 7 cases of acetabular fractures with quadrilateral involvement, and 2 cases of acetabular fractures with central dislocation.All 21 patients were followed up for 12 to 36 months with an average of (18.60±6.45) months. All fractures healed. According to Matta's image reduction evaluation after operation, 11 cases of pelvic anterior and posterior column fractures were all anatomic reduction, 1 case was satisfactory reduction, 7 cases of acetabular fractures involving quadrilateral were anatomic reduction, 1 case with central dislocation was anatomic reduction, and 1 case was satisfactory reduction. The modified Merle D'Aubigne Postel hip joint score was 13 to 17 points.Lateral incision approach of rectus abdominis combined with wing-shaped steel plate can obtain good radiological and clinical results in the treatment of complex pelvic and acetabular fractures involving quadrilateral bodies, and has advantages in the treatment of complex pelvic fractures and acetabular quadrilateral fractures.
Cotton fabric was treated with pure silica sol and boron doped partner through sol-gel method in order to improve its thermal and combustion properties. The results of thermo-gravimetric analysis, micro combustion calorimeter, and smoke density test of control showed that the finished cotton fabric had excellent thermal stability and mild combustion behavior with lower heat release rate. Furthermore, the smoke density test also indicated the safety performance of the boron doped silica sol treated cotton fabric in the fire.
Abstract Background Coronavirus disease 2019 (COVID-19) has spurred a boom in uncovering repurposable existing drugs. Drug repurposing is a strategy for identifying new uses for approved or investigational drugs that are outside the scope of the original medical indication. Motivation Current works of drug repurposing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mostly limited to only focusing on chemical medicines, analysis of single drug targeting single SARS-CoV-2 protein, one-size-fits-all strategy using the same treatment (same drug) for different infected stages of SARS-CoV-2. To dilute these issues, we initially set the research focusing on herbal medicines. We then proposed a heterogeneous graph embedding method to signaled candidate repurposing herbs for each SARS-CoV-2 protein, and employed the variational graph convolutional network approach to recommend the precision herb combinations as the potential candidate treatments against the specific infected stage. Method We initially employed the virtual screening method to construct the ‘Herb-Compound’ and ‘Compound-Protein’ docking graph based on 480 herbal medicines, 12,735 associated chemical compounds and 24 SARS-CoV-2 proteins. Sequentially, the ‘Herb-Compound-Protein’ heterogeneous network was constructed by means of the metapath-based embedding approach. We then proposed the heterogeneous-information-network-based graph embedding method to generate the candidate ranking lists of herbs that target structural, nonstructural and accessory SARS-CoV-2 proteins, individually. To obtain precision synthetic effective treatments forvarious COVID-19 infected stages, we employed the variational graph convolutional network method to generate candidate herb combinations as the recommended therapeutic therapies. Results There were 24 ranking lists, each containing top-10 herbs, targeting 24 SARS-CoV-2 proteins correspondingly, and 20 herb combinations were generated as the candidate-specific treatment to target the four infected stages. The code and supplementary materials are freely available at https://github.com/fanyang-AI/TCM-COVID19.
'/%3e%3cuse xlink:href='%23a' transform='rotate(23.036 .093 25.536)'/%3e%3cuse xlink:href='%23a' transform='rotate(45.87 1.273 16.18)'/%3e%3cuse xlink:href='%23a' transform='rotate(69.945 .996 12.078)'/%3e%3cuse xlink:href='%23a' transform='rotate(20.66 -19.689 31.932)'/%3e%3c/svg%3e)