Jajula Kashanna

Rajiv Gandhi University of Knowledge Technologies

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ravada Kishore

GITAM University

Rathod Aravind Kumar

Indian Institute of Chemical Technology

Paramesh Jangili

Korea University

Biswanath Das

Indian Institute of Chemical Technology

Bharat Kumar Tripuramallu

Vignan's Foundation for Science, Technology & Research

Ananda Kumar Jami

GITAM University

Pilli V.V.N. Kishore

Amrita Institute of Medical Sciences and Research Centre

Biswanath Das

Indian Institute of Technology Bhubaneswar

Anandarup Goswami

Palacký University Olomouc

Varadhi Govinda

GITAM University

Cooperative Institutions

Indian Institute of Chemical Technology

University of Hyderabad

GITAM University

Vignan's Foundation for Science, Technology & Research

Osmania University

Academy of Scientific and Innovative Research

Dr. Reddy's Laboratories (India)

Biological E (India)

Council of Scientific and Industrial Research

Sri Venkateswara University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Multicomponent one-pot synthesis of 2-naphthol derivatives and evaluation of their anticancer activity

Medicinal Chemistry Research (2011)

Biswanath Das Cheruku Ravindra Reddy Jajula Kashanna Suman Kumar Mamidyala C. Ganesh Kumar

HeLa

Anisole

Cancer cell lines

10.1007/s00044-011-9884-x

Cite

Citations (43)

ChemInform Abstract: Novel Synthetic Methodologies. Part 210. Indium(III) Chloride‐Catalyzed Conversion of {[(Benzyloxy)carbonyl]amino}‐Substituted Sulfones with 2‐[(Trimethylsilyl)oxy]furan: A Facile Access to γ‐Butenolactone Derivatives Containing a Protected Amino Group.

ChemInform (2011)

Biswanath Das Chithaluri Sudhakar Parigi Raghavendar Reddy Jajula Kashanna

Abstract Various racemic γ‐butenolactones are prepared with moderate anti‐selectivities tolerating aromatic, heteroaromatic and aliphatic substituents and a range of functional groups.

Furan

Trimethylsilyl

Trimethylsilyl chloride

Isocoumarins

10.1002/chin.201142086

Cite

Citations (0)

ChemInform Abstract: Studies on Novel Synthetic Methodologies. Part 226. Organic Reactions in Water: A Distinct Approach for the Synthesis of Quinoline Derivatives Starting Directly from Nitroarenes.

ChemInform (2012)

Biswanath Das Paramesh Jangili Jajula Kashanna Rathod Aravind Kumar

Abstract The biologically interesting quinoline skeleton is readily available in good to excellent yield and functional groups including halogens remain unaffected.

Quinoline

10.1002/chin.201207137

Cite

Citations (0)

Synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles in water using p-dodecylbenzenesulfonic acid as catalyst

Monatshefte für Chemie - Chemical Monthly (2012)

Biswanath Das Jajula Kashanna Rathod Aravind Kumar Paramesh Jangili

Benzil

10.1007/s00706-012-0770-0

Cite

Citations (42)

ChemInform Abstract: Efficient Organocatalytic Synthesis of 1,8-Dioxo-octahydroxanthenes.

ChemInform (2012)

Biswanath Das Jajula Kashanna Rathod Aravind Kumar Paramesh Jangili

10.1002/chin.201250144

Cite

Citations (0)

Design, synthesis and biological evaluation of novel substituted indazole-1,2,3-triazolyl-1,3,4-oxadiazoles: Antimicrobial activity evaluation and docking study

Results in Chemistry (2022)

Ananda Kumar Dunga Tejeswara Rao Allaka Yugandhar Kethavarapu Sunil Kumar Nechipadappu Pradeep Pothana

A novel series of dual 1,2,3–triazole and 1,3,4–oxadiazole heterocyclic compounds linked to indazole were designed and efficiently synthesized using 3-bromo-1H-indazole as potential antimicrobial agents. All the compounds were characterized by their proton, carbon nuclear magnetic resonance, infrared, mass spectral data, and elemental analysis. The final compounds 9a–m were evaluated in vitro antimicrobial activity against Gram–negative microorganism E. coli, Gram–positive microorganisms B. subtilis, S. pneumoniae, S. aureus and antifungal strains A. fumigates, C. albicans. From biological screening, we were surprised to find that most of the compounds have significant inhibitory activity and in particular dual heterocycles 9b, 9c, 9h, 9i, and 9j showed outstanding antibacterial activity against Gram–positive bacteria S. pneumoniae with MICs 5.4 ± 0.02, 5.8 ± 0.03, 8.0 ± 0.04, 4.0 ± 0.03, and 7.8 ± 0.01 µg/mL respectively, when compared to ampicillin [MIC = 9.1 ± 0.01 µg/mL]. Final prepared scaffolds 9b, 9h acquiring highest potential drug scores ΔG = –7.78, –8.34 Kcal/mol with their amino acids residues Arg171 (O…H: 1.934), Lys20 (N…H: 1.951), Arg265 (N…H: 2.080), ArgA:171 (2.740), ArgA:265 (1.874), TyrA:248 (1.973), and Ser19 (H…O: 2.048), Tyr248 (O…H: 1.570), Arg265 (N…H: 1.976), Arg46 (N…H: 1.059) ArgA:45 (O…H, 2.94 Å) respectively.

Indazole

Thiazole

Triazole

10.1016/j.rechem.2022.100605

Cite

Citations (14)

Design, Synthesis and Cytotoxicity of New Coumarin‐1,2,3‐triazole Derivatives: Evaluation of Anticancer Activity and Molecular Docking Studies

Chemistry & Biodiversity (2023)

Victor Premsagar Miriyala Prakash Raj Thommandru Jajula Kashanna Varadhi Govinda G. Ravi

A library of new coumarin-1,2,3-triazole hybrids 7a-l were synthesized from 4-(diethylamino)-2-hydroxybenzaldehyde precursor through a series of reactions including Vilsmeier-Haack reaction and condensation reaction to achieve key intermediate oxime and further performed click reaction by using different aromatic azides. We screened all molecules in silico against crystal structure of Serine/threonine-protein kinase 24 (MST3), based on these results all molecules were screened for their cytotoxicity against human breast cancer MCF-7 and lung cancer A-549 cell lines. Compound 7 b (p-bromo) showed best activity against both cell lines MCF-7 and A-549 with IC

Docking (animal)

1,2,3-Triazole

Triazole

10.1002/cbdv.202300269

Cite

Citations (7)

CCDC 1470625: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Jajula Kashanna Koppanathi Nagaraju K. C. Kumara Swamy

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1lc9js

Cite

Citations (0)

CCDC 2124693: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Ravada Kishore Jajula Kashanna Bharat Kumar Tripuramallu

10.5517/ccdc.csd.cc299xh1

Cite

Citations (0)

The First Stereoselective Total Synthesis of a Naturally Occurring Bioactive Diarylheptanoid, (3R,6E)‐1,7‐Bis(4‐hydroxyphenyl)hept‐6‐en‐3‐ol, through Two Different Approaches

Helvetica Chimica Acta (2012)

Jajula Kashanna Paramesh Jangili Rathod Aravind Kumar Biswanath Das

Abstract The stereoselective total synthesis of a naturally occurring bioactive diarylheptanoid, (3 R ,6 E )‐1,7‐bis(4‐hydroxyphenyl)hept‐6‐en‐3‐ol, has been accomplished starting from 4‐hydroxybenzaldehyde through two different approaches involving Wittig olefination, hydrolytic kinetic resolution of a racemic epoxide, and olefin cross‐metathesis reaction as the key steps.

Kinetic resolution

Wittig reaction

10.1002/hlca.201200084

Cite

Citations (8)