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Ángel R. Nebreda

Spanish National Cancer Research Centre

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Ana Igea

Navarre Institute of Health Research

Marçal Vilar

Instituto de Biomedicina de Valencia

Begoña Cánovas

Institute for Research in Biomedicine

Modesto Orozco

Institute for Research in Biomedicine

Patrick Aloy

Institució Catalana de Recerca i Estudis Avançats

Roger R. Gomis

Centro de Investigación Biomédica en Red de Cáncer

Iván del Barco Barrantes

AstraZeneca (United Kingdom)

Víctor Alcalde

Translational Therapeutics (United States)

Samira Jaeger

Institute for Research in Biomedicine

Rodrigo Arroyo

Universidad del Desarrollo

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Institute for Research in Biomedicine

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Universitat de Barcelona

Instituto de Salud Carlos III

Consejo Superior de Investigaciones Científicas

Inserm

Centre National de la Recherche Scientifique

Centro de Investigación Biomédica en Red de Cáncer

Centro de Investigación Biomédica en Red

Spanish National Cancer Research Centre

Universitat Autònoma de Barcelona

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RINGO efficiently triggers meiosis resumption in mouse oocytes and induces cell cycle arrest in embryos

Biology of the Cell (2001)

Marie‐Emilie Terret Ingvar Ferby Ángel R. Nebreda Marie‐Hélène Verlhac

Summry— RINGO was identified as a Cdc2‐binding and activating protein which is necessary and sufficient to trigger G2/M progression in Xenopus oocytes. We have investigated whether the function of RINGO is conserved in mouse oocytes. We show that RINGO induces Germinal Vesicle BreakDown (GBVD) in mouse oocytes. Mos is known to induce GVBD in mouse oocytes, and is also involved in the metaphase II arrest, which is due to the CSF (CytoStatic Factor) activity. We found that RINGO also has CSF activity and induces cleavage arrest after injection into one blastomere of a late two‐cell mouse embryo, like Mos. However, RINGO also inhibits polar body extrusion of wild type mouse oocytes. The same effect of RINGO on first and second polar body extrusion was observed in Mos ‐ /‐ mouse oocytes. The injection of RINGO mimics Mos effects: GVBD induction and efficient cleavage arrest. However, our results in mouse oocytes suggest that RINGO may have additional functions in meiosis regulation.

Germinal vesicle

Blastomere

Cleavage (geology)

10.1016/s0248-4900(01)01122-4

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Citations (18)

Self‐associating properties of yeast exo‐β‐glucanases are dependent on the ionic strength

FEBS Letters (1982)

Ángeles Sánchez Ángel R. Nebreda Tomás G. Villa

Reprint

10.1016/0014-5793(82)80170-1

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Citations (3)

Diversity and versatility of p38 kinase signalling in health and disease

Nature Reviews Molecular Cell Biology (2021)

Begoña Cánovas Ángel R. Nebreda

Signalling

Cell Signaling

Cell type

Cellular stress response

10.1038/s41580-020-00322-w

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Citations (408)

TEF-1 and C/EBPβ are major p38α MAPK-regulated transcription factors in proliferating cardiomyocytes

Biochemical Journal (2006)

Concetta Ambrosino Tomoko Iwata Claudio Scafoglio Massimo Mallardo Rüdiger Klein

p38 MAPKs (mitogen-activated protein kinases) play important roles in the regulation of cellular responses to environmental stress. Recently, this signalling pathway has also been implicated in the regulation of processes unrelated to stress, for example, in T lymphocytes and cardiomyocytes. In order to identify molecular targets responsible for the housekeeping functions of p38 MAPKs, we have analysed the differences in the transcriptomes of normally proliferating wild-type and p38α knockout immortalized embryonic cardiomyocytes. Interestingly, many potential components of the myocardium extracellular matrix were found to be upregulated in the absence of p38α. Further analysis of the microarray data identified TEF-1 (transcriptional enhancer factor-1), a known regulator of heart-specific gene expression, and C/EBPβ (CCAAT/enhancer-binding protein β), as the two transcription factors the binding sites of which were most enriched in the promoters of p38α-regulated genes. We have focused on the study of the extracellular matrix component COL1A1 (α1 chain of type I collagen) and found evidence for the involvement of both TEF-1 and C/EBPβ in the p38α-dependent inhibition of COL1A1 transcription. Our data therefore show that p38 MAPKs regulate TEF-1 and C/EBPβ transcriptional activity in the absence of environmental stress and suggests a role for p38α in the expression of extracellular matrix components that maintain organ architecture.

Ccaat-enhancer-binding proteins

Transcription

10.1042/bj20051502

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Citations (43)

Feedback control of the protein kinase TAK1 by SAPK2a/p38

The EMBO Journal (2003)

Peter Cheung David G. Campbell Ángel R. Nebreda Philip Cohen

10.1093/emboj/cdg552

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Citations (277)

p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin‐induced liver failure

EMBO Reports (2008)

Jan Heinrichsdorff Tom Luedde Eusebio Perdiguero Ángel R. Nebreda Manolis Pasparakis

10.1038/embor.2008.149

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Citations (94)

Faculty Opinions recommendation of The juxtamembrane region of the EGF receptor functions as an activation domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2009)

Ángel R. Nebreda Marçal Vilar

10.3410/f.1161732.623324

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Faculty Opinions recommendation of Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2005)

Ángel R. Nebreda

The ablation of the protein kinase Raf-1 renders cells hypersensitive to apoptosis despite normal regulation of extracellular signal-regulated kinases, which suggests that apoptosis protection is mediated by a distinct pathway. We used proteomic analysis of Raf-1 signaling complexes to show that Raf-1 counteracts apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). Raf-1 prevents dimerization and phosphorylation of the activation loop of MST2 independently of its protein kinase activity. Depletion of MST2 from Raf-1-/- mouse or human cells abrogated sensitivity to apoptosis, whereas overexpression of MST2 induced apoptosis. Conversely, depletion of Raf-1 from Raf-1+/+ mouse or human cells led to MST2 activation and apoptosis. The concomitant depletion of both Raf-1 and MST2 prevented apoptosis. PMID: 15618521

10.3410/f.1022959.270706

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Possible role of cAMP in the synthesis of Î²-glucanases and Î²-xylanases ofBacillus circulansWL-12

FEMS Microbiology Letters (1984)

Rosa Esteban Ángel R. Nebreda J. R. Villanueva Tomás G. Villa

Bacillus circulans WL-12 secretes 1,4-β-d-xylanase and 1,3-β-d- and 1,6-β-d-glucanase activities. All of them are catabolites regulated by glucose and, while xylanase needs xylan as the inducer, the two latter enzyme activities are formed once glucose is depleted. Cyclic nucleotides such as adenosine 3′,5′-monophosphate (cAMP) and guanosine 3′,5′ monophosphate (cGMP) exhibit a negative effect on enzyme synthesis if added to the culture media. Based on the fact that only cAMP is found in cells growing in glucose-rich media we propose a model for B. circulans WL-12 in which cAMP acts as a negative effector for regulating the synthesis of these enzymes. The model is not, however, extrapolated to other Bacillus species and all B. circulans strains.

Bacillus circulans

Inducer

Bacillus (shape)

10.1111/j.1574-6968.1984.tb01041.x

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Citations (8)

Supplementary Figure 13 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

<p>Distribution of DCI values (DCI20 to DCI80) ranging from 20 to 80% of proliferation inhibition (IC20 to IC80) for DC01 to DC10.</p>

Cancer drugs

10.1158/0008-5472.22415243.v1

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