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Ángela Ávila-Fernández

Universidad Juárez Autónoma de Tabasco

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Agustı́n López-Munguı́a

Universidad Nacional Autónoma de México

Clarita Olvera

Universidad Nacional Autónoma de México

Isela Esther Juárez‐Rojop

Universidad Juárez Autónoma de Tabasco

María Elena Rodríguez-Alegría

Universidad Nacional Autónoma de México

Carlos Alfonso Tovilla‐Zárate

Universidad Juárez Autónoma de Tabasco

Thelma Beatriz González‐Castro

Universidad Juárez Autónoma de Tabasco

Alma Delia Genis‐Mendoza

National Institute of Genomic Medicine

Jorge L. Blé‐Castillo

Universidad Juárez Autónoma de Tabasco

José Antonio Morales-Contreras

Universidad Juárez Autónoma de Tabasco

Jaime Ricardo Porras-Domínguez

KU Leuven

Cooperative Institutions

Universidad Juárez Autónoma de Tabasco

Universidad Nacional Autónoma de México

Universidad Autónoma del Estado de Morelos

Instituto Politécnico Nacional

Universidade do Porto

Consejo Superior de Investigaciones Científicas

Universitat de Miguel Hernández d'Elx

Secretaria de Salud

Rede de Química e Tecnologia

University of Florida

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Processing of Fructans and Oligosaccharides from Agave Plants

Elsevier eBooks (2014)

Clarita Olvera Ángela Ávila-Fernández Gustavo R. Bustillo Armendáriz Agustín López‐Munguía

Agave

Fructan

10.1016/b978-0-12-404699-3.00015-9

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Citations (27)

Prebióticos: Alternativas mexicanas

Horizonte Sanitario (2014)

Ángela Ávila-Fernández

Los prebióticos son ingredientes alimenticios no digeribles que al ser metabolizados por algunos géneros de bacterias que componen la microbiota del colon proporcionan un efecto benéfico al hospedero. Entre los prebióticos más estudiados se encuentran las fructanas o fructanos que son polímeros compuestos por unidades de fructosa unidas mediante enlaces de tipo (2-1) y/o (2-6). Existe una amplia variedad de fructanas caracterizadas por las peculiaridades de su estructura, sin embargo, suelen denominarse de forma general inulinas cuando el enlace que predomina es el (2-1) y levanas cuando el enlace que predomina es el enlace (2-6). Normalmente, las fructanas tienen una unidad de glucosa en el extremo, por lo que pueden ser consideradas como moléculas de sacarosa que han sido extendidas mediante la adición de unidades de fructosa. Cuando el grado de polimerización de las fructanas es menor a 10, es decir, cuando poseen un número de residuos de fructosa entre 2 y 10 son llamadas oligofructosa o fructooligosacáridos (FOS).

10.19136/hs.a12n1.149

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Molecular characterization of sucrose: sucrose 1-fructosyltransferase (1-SST) from Agave tequilana Weber var. azul.

Plant Science (2007)

Ángela Ávila-Fernández Clarita Olvera E. Rudiño-Piñera Gladys I. Cassab Jorge Nieto‐Sotelo

Agave

Fructan

Cichorium

Hydrolase

10.1016/j.plantsci.2007.07.009

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Citations (33)

Morphological and physicochemical changes in the cassava (Manihot esculenta) and sweet potato (Ipomoea batata) starch modified by pyrodextrinization

Food Science and Technology (2022)

Zeniff Reyes-López David Betancur‐Ancona Jorge L. Blé‐Castillo Isela Esther Juárez-Rojop Ángela Ávila-Fernández

In recent years, resistant starch (RS) and slowly digestible starch (SDS) have been linked to the prevention of chronic noncommunicable diseases, such as obesity and its complications. Southern Mexico has an important role in the tuber crop production of M. esculenta and I. batatas, which contain considerable amounts of starch. The aim of this study was to evaluate the morphological and physicochemical changes of M. esculenta and I. batatas after pyrodextrinization, including the production of RS and SDS. The factors used in this study were the starch/acid ratio (2.2 HCl) (80:1 and 160:1 p/v); temperature (90 °C and 110 °C) and reaction time (1 and 3 h). The highest production of RS in M. esculenta was obtained with the highest starch/acid ratio and temperature, and the lowest reaction time. For pyrodextrins, loss of crystallinity and an increase in swelling power and water absorption capacity were observed. The highest production of RS in I. batatas was obtained with the highest starch/acid ratio and reaction time, and the lowest temperature. Crystallinity and enthalpy of gelatinization decreased in modified starches. The solubility, swelling power and water absorption capacity increased in both sources.

Resistant Starch

Manihot esculenta

Ipomoea

Manihot

10.1590/fst.40922

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Citations (2)

Bacillus subtilis 168 levansucrase (SacB) activity affects average levan molecular weight

Carbohydrate Polymers (2015)

Jaime Ricardo Porras-Domínguez Ángela Ávila-Fernández Alfonso Miranda‐Molina María Elena Rodríguez-Alegría Agustín López‐Munguía

Levansucrase

Fructan

Molar mass distribution

10.1016/j.carbpol.2015.06.056

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Citations (64)

Supplementary Material for: Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

Figshare (2018)

Alma Delia Genis‐Mendoza María Lilia López‐Narváez Carlos Alfonso Tovilla‐Zárate Esteban E. Sarmiento Adriana Chavez

Background: The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population. Methods: We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models. Results: Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56–5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37–5.75) as well as males (OR = 3.3; 95% CI 1.01–10.77). Conclusion: Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.

Association (psychology)

10.6084/m9.figshare.6729347

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Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

Neuropsychobiology (2017)

Alma Delia Genis‐Mendoza María Lilia López‐Narváez Carlos Alfonso Tovilla‐Zárate Emmanuel Sarmiento Adriana Chavez

The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population.We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models.Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56-5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37-5.75) as well as males (OR = 3.3; 95% CI 1.01-10.77).Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.

10.1159/000490071

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Citations (12)

Prebióticos: Alternativas mexicanas

Horizonte Sanitario (2014)

Ángela Ávila-Fernández

Los prebióticos son ingredientes alimenticios no digeribles que al ser metabolizados por algunos géneros de bacterias que componen la microbiota del colon proporcionan un efecto benéfico al hospedero. Entre los prebióticos más estudiados se encuentran las fructanas o fructanos que son polímeros compuestos por unidades de fructosa unidas mediante enlaces de tipo (2-1) y/o (2-6). Existe una amplia variedad de fructanas caracterizadas por las peculiaridades de su estructura, sin embargo, suelen denominarse de forma general inulinas cuando el enlace que predomina es el (2-1) y levanas cuando el enlace que predomina es el enlace (2-6). Normalmente, las fructanas tienen una unidad de glucosa en el extremo, por lo que pueden ser consideradas como moléculas de sacarosa que han sido extendidas mediante la adición de unidades de fructosa. Cuando el grado de polimerización de las fructanas es menor a 10, es decir, cuando poseen un número de residuos de fructosa entre 2 y 10 son llamadas oligofructosa o fructooligosacáridos (FOS).

10.19136/hs.v12i1.149

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Citations (0)

Analysis of formulations of probiotics accessible to the population of Tabasco, México

Horizonte Sanitario (2021)

Ángela Ávila-Fernández Andrea Cristostomo-Jiménez José Antonio Morales-Contreras Isela Esther Juárez‐Rojop Mirian Carolina Martínez‐López

Objective: In this study, formulations containing probiotics that are sold in establishments in the State of Tabasco were identified, their composition was analyzed and compared with formulations that can be purchased online. Materials and methods: The formulations containing probiotics sold in 21 establishments in the city of Villahermosa were identified and compared with 30 probiotic supplements sold online. Products information was registered in a database and analyzed according to their dosage form, the probiotics genera, species / subspecies that contain and their classification as probiotics or symbiotics and as drugs or supplements. Results: 31 local products and 30 products sold online, formulated with probiotics, in 6 different dosage forms were analyzed. Only 5 of the local products and none sold online are certified by COFEPRIS as drugs. 48% of the formulations are monostrain and the rest are multistrain. 72% of the formulations are probiotics and the rest are synbiotic. In the 61 products analyzed were identified 46 species belonging to 13 different genera, 39% were common to local and online products. The Lactobacillus and Bifidobacterium genera highlight due to their abundance of species and the number of products that contain them. The genus Bacillus was the only one that was never combined with species of other genera in the formulations. Conclusions: The population of the state of Tabasco can find at least 31 formulations containing probiotics in local establishments. The variety increases if we consider the dietary supplements that can be purchased online. In particular, multistrain supplements. The products certified by COFEPRIS ensure that the benefits of the formulation are supported by clinical trials in humans and are manufactured following the good manufacturing practices.

10.19136/hs.a20n2.4140

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Simultaneous enzyme production, Levan-type FOS synthesis and sugar by-products elimination using a recombinant Pichia pastoris strain expressing a levansucrase-endolevanase fusion enzyme

Microbial Cell Factories (2023)

Ángela Ávila-Fernández Silvia Montiel María Elena Rodríguez-Alegría Luis Caspeta Agustín López‐Munguía

Abstract Background Although Levan-type fructooligosaccharides (L-FOS) have been shown to exhibit prebiotic properties, no efficient methods for their large-scale production have been proposed. One alternative relies on the simultaneous levan synthesis from sucrose, followed by endolevanase hydrolysis. For this purpose, several options have been described, particularly through the synthesis of the corresponding enzymes in recombinant Escherichia coli. Major drawbacks still consist in the requirement of GRAS microorganisms for enzyme production, but mainly, the elimination of glucose and fructose, the reaction by-products. Results The expression of a fusion enzyme between Bacillus licheniformis endolevanase (LevB1) and B. subtilis levansucrase (SacB) in Pichia pastoris cultures, coupled with the simultaneous synthesis of L-FOS from sucrose and the elimination of the residual monosaccharides, in a single one-pot process was developed. The proof of concept at 250 mL flask-level, resulted in 8.62 g of monosaccharide-free L-FOS and 12.83 gDCW of biomass, after 3 successive sucrose additions (30 g in total), that is a 28.7% yield (w L-FOS/w sucrose) over a period of 288 h. At a 1.5 L bioreactor-level, growth considerably increased and, after 59 h and two sucrose additions, 72.9 g of monosaccharide-free L-FOS and 22.77 gDCW of biomass were obtained from a total of 160 g of sucrose fed, corresponding to a 45.5% yield (w L-FOS/w sucrose), 1.6 higher than the flask system. The L-FOS obtained at flask-level had a DP lower than 20 fructose units, while at bioreactor-level smaller oligosaccharides were obtained, with a DP lower than 10, as a consequence of the lower endolevanase activity in the flask-level. Conclusion We demonstrate here in a novel system, that P. pastoris cultures can simultaneously be used as comprehensive system to produce the enzyme and the enzymatic L-FOS synthesis with growth sustained by sucrose by-products. This system may be now the center of an optimization strategy for an efficient production of glucose and fructose free L-FOS, to make them available for their application as prebiotics. Besides, P. pastoris biomass also constitutes an interesting source of unicellular protein.

Levansucrase

Monosaccharide

Zymomonas mobilis

10.1186/s12934-022-02009-7

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Citations (12)