Vítězslav Maier

Palacký University Olomouc

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JŠ

Juraj Ševčı́k

Palacký University Olomouc

Jan Petr

Palacký University Olomouc

Joanna Znaleziona

Regional Centre of Advanced Technologies and Materials

MŠ

Martin Švidrnoch

University of Ostrava

Radim Knob

Brigham Young University

Václav Ranc

Institute of Molecular and Translational Medicine

Jana Horáková

Palacký University Olomouc

Peter Ondra

University Hospital Olomouc

Pavlína Ginterová

KIST Europe

JŠ

Juraj Ševčík

Palacký University Olomouc

Cooperative Institutions

Palacký University Olomouc

Regional Centre of Advanced Technologies and Materials

Charles University

University Hospital Olomouc

Institute of Molecular and Translational Medicine

Czech Academy of Sciences

Czech Academy of Sciences, Institute of Experimental Botany

Czech Academy of Sciences, Institute of Microbiology

Mendel University in Brno

Masaryk University

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Using of S-(−)-2-hydroxymethyl-1,1-dimethylpyrrolidinium tetrafluoroborate as additive to the background electrolyte in capillary electrophoresis

Journal of Chromatography A (2005)

Vítězslav Maier Jana Horáková Jan Petr Dušan Drahoňovský Juraj Ševčı́k

Hydroxymethyl

Tetrafluoroborate

10.1016/j.chroma.2005.11.011

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Citations (24)

A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography

Open Chemistry (2010)

Kateřina Vítková Markéta Pechová Jan Petr Joanna Znaleziona Václav Ranc

Abstract A method for the fast determination of yohimbine, a potent adrenoreceptor antagonist used for the treatment of sexual dysfunctions, is proposed in this article. MEKC under basic and acidic conditions (sodium borate, pH 9.5 and sodium phosphate, pH 2.5) with SDS was developed. The effect of the experimental parameters, e.g. pH, SDS concentration and injection time, on yohimbine migration was also studied. Both methods were validated in terms of linearity, limits of detection and quantification, accuracy, and precision using caffeine as an internal standard. The application for the determination of yohimbine in hand-made medicaments is also investigated in this study.

Micellar electrokinetic chromatography

10.2478/s11532-009-0149-1

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Citations (3)

Contribution of Methane Benthic and Atmospheric Fluxes of an Experimental Area (Sitka Stream)

CLEAN - Soil Air Water (2015)

Adam Bednařík Lubomı́r Čáp Vítězslav Maier Martin Rulı́k

Contributions of methane benthic fluxes and methane emissions to the total methane amount were studied during the summer season for two consecutive years. Considering the fact that methane is produced in great amount within hyporheic sediments, we have expected that both methane released by the benthic fluxes into the overlying water and methane emitted to the atmosphere should significantly affect the total methane budget of the stream water within the experimental area. In order to asses this assumption, we measured methane concentrations within the vertical sediment profile of a hyporheic zone, direct benthic methane fluxes by static chambers, methane concentrations in the surface water, and methane emissions into the atmosphere simultaneously. The methane concentrations in interstitial water tended sharply to increase with sediment depth (0.54–734.99 μmol L−1) and were strongly correlated with benthic fluxes (r = 0.88, p < 0.05). We also found a considerable variability in the benthic methane fluxes (0–12.59 mmol m−2 day−1) and the spatial variability (0–71.43%) of the experimental area, suggesting that there may be various factors that affect the rate of benthic fluxes including methanotrophy in the top sediment layers. Generally, the contribution of benthic fluxes and methane emissions to the methane budgets of the experimental area was negligible (0.034 (0.45%) and 0.074 mol day−1 (0.98%), respectively).

Atmospheric methane

10.1002/clen.201300982

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Citations (18)

Analysis of Microorganisms by Capillary Electrophoresis

Chemické listy (2008)

Olga Ryparová Jan Petr Marta Kowalska Joanna Znaleziona R. Knob

Utilization of capillary electrophoresis for screening identification of Escherichia coli in water (faecal contamination) and pharmaceuticals is described. The method uses an electrolyte 4.5 mM in Tris, 4.5 mM in H3BO3 and 0.1 mM in EDTA with 0.0125 % poly(ethylene oxide). A brief survey of the published methods for analysis of microorganisms by capillary electrophoresis is given.

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Enantioseparation of d,l-2-hydroxyglutaric acid by capillary electrophoresis with tandem mass spectrometry—Fast and efficient tool for d- and l-2-hydroxyglutaracidurias diagnosis

Journal of Chromatography A (2016)

Martin Švidrnoch Adam Přibylka Vojtěch Bekárek Juraj Ševčı́k Vratislav Smolka

Capillary electrophoresis–mass spectrometry

Dansyl chloride

10.1016/j.chroma.2016.05.095

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Citations (19)

Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice

Journal of Medicinal Chemistry (2022)

Aneta Grycová Hansol Joo Vítězslav Maier Peter Illéš Barbora Vyhlídalová

Targeting the aryl hydrocarbon receptor (AhR) is an emerging therapeutic strategy for multiple diseases (e.g., inflammatory bowel disease). Thermosporothrix hazakensis microbial metabolite 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is a putative AhR endogenous ligand. To improve the chemical stability, we synthesized a series of ITE chemical mimics. Using a series of in vitro assays, we identified 2-(1H-indole-3-carbonyl)-N-methyl thiazole-4-carboxamide (ITE-CONHCH3) as a highly potent (EC50 = 1.6 nM) AhR agonist with high affinity (Ki = 88 nM). ITE-CONHCH3 triggered AhR nuclear translocation and dimerization of AhR-ARNT, enhanced AhR binding in the CYP1A1 promoter, and induced AhR-regulated genes in an AhR-dependent manner. The metabolic stability of ITE-CONHCH3 in a cell culture was 10 times higher than that of ITE. Finally, we observed protective effects of ITE-CONHCH3 in mice with DSS-induced colitis. Overall, we demonstrate and validate a concept of microbial metabolite mimicry in the therapeutic targeting of AhR.

Thiazole

10.1021/acs.jmedchem.2c00208

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Citations (16)

Determination of brominated phenols in water samples by on-line coupled isotachophoresis with capillary zone electrophoresis

Journal of Chromatography A (2010)

Radim Knob Jozef Marák Andrea Vojs Staňová Vítězslav Maier Dušan Kaniansky

Isotachophoresis

Repeatability

Sodium hydroxide

Hydrochloric acid

10.1016/j.chroma.2010.03.006

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Citations (15)

The use of PAMAM dendrimers as a dynamic coating for cyclodextrin mediated enantioseparation of selected basic drugs

Analytical Methods (2016)

Joanna Znaleziona Vítězslav Maier

A dynamic coating using polyamidoamine (PAMAM) dendrimers was used to change the direction and magnitude of electroosmotic flow.

10.1039/c5ay03070f

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Citations (4)

On-line Preconcentration Techniques in Capillary Electrophoresis

Chemické listy (2006)

Jana Horáková Vítězslav Maier J. Ševčík

Preconcentration is a very important issue for achievement of low detection limits. Various on-line preconcentration modes, various electrolyte compositions, pH values and mechanisms responsible for the focusing effect are described in literature. The main modes of stacking, sweeping and transient isotachophoresis are discussed. Some of the described methods are combinations of major techniques of preconcentration and less known focusing techniques. References for optimization of focusing conditions and routine use of on-line preconcentration are given.

Isotachophoresis

Line (geometry)

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Electrochemical oxidation of berberine and mass spectrometric identification of its oxidation products

Bioelectrochemistry (2011)

Jana Skopalová Jan Vacek Barbora Papoušková David Jirovský Vítězslav Maier

Glassy carbon

10.1016/j.bioelechem.2011.09.002

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Citations (21)