Saeid Abediankenari

Mazandaran University of Medical Sciences

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Narjes Jafari

Mazandaran University of Medical Sciences

Maryam Ghasemi

Mazandaran University of Medical Sciences

Nourollah Sadeghzadeh

Mazandaran University of Medical Sciences

Alireza Rafiei

Emory University

Zahra Rahmani

Shahid Beheshti University of Medical Sciences

Hossein Ranjbaran

Mazandaran University of Medical Sciences

Seyed Mohammad Abedi

Mazandaran University of Medical Sciences

Zahra Kashi

Mazandaran University of Medical Sciences

Alireza Mardomi

Islamic Azad University of Tabriz

Saeideh Sadat Shobeiri

Sabzevar University of Medical Sciences

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Mazandaran University of Medical Sciences

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Tehran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Imam Khomeini Hospital

Iran University of Medical Sciences

University of Mazandaran

Babol University of Medical Sciences

University of Tehran

Pasteur Institute of Iran

Shiraz University of Medical Sciences

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Toxoplasmosis among cancer patients undergoing chemotherapy: a population study based on the serological, molecular and epidemiological aspects

Transactions of the Royal Society of Tropical Medicine and Hygiene (2020)

Seyed Abdollah Hosseini Mehdi Sharif Shahabeddin Sarvi Ghasem Janbabai Shahrbanoo Keihanian

Toxoplasmosis is highly prevalent in northern Iran and immunocompromised individuals are more susceptible to this infection. The present study aimed to determine the seroprevalence, parasitism and genetic diversity of Toxoplasma gondii among patients with cancer undergoing chemotherapy in northern Iran.A total of 350 serum samples obtained from cancer patients were collected from laboratory centers in northern Iran. Immunodiagnosis and DNA detection were accomplished by ELISA and PCR. Thereafter, multiplex-nested PCR-restriction fragment length polymorphism was used for the genotyping of T. gondii.In general, out of 350 patients, 264 (75.4%) and 9 (2.57%) cases were positive for anti-T. gondii IgG and IgM, respectively. Moreover, 19 (5.43%) samples contained T. gondii DNA. From 19 positive samples, 10 high-quality samples with sharp and non-smear bands were selected to determine the genotypes of T. gondii. Accordingly, the samples were classified as genotype #1 (type II clonal; n=4, 40%), genotype #2 (type III clonal; n=3, 30%), genotype #10 (type I clonal; n=2, 20%) and genotype #27 (type I variant; n=1, 10%).As evidenced by the results, due to the high prevalence of T. gondii, cancer patients in northern Iran are at serious risk of severe toxoplasmosis and its complications. Therefore, oncologists need to regard this critical health problem as a matter requiring urgent attention.

Toxoplasmosis

Seroprevalence

10.1093/trstmh/traa112

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MicroRNA-34 dysregulation in gastric cancer and gastric cancer stem cell

Tumor Biology (2017)

Narjes Jafari Saeid Abediankenari

Gastric cancer is a major cause of cancer mortality worldwide, with a low survival rate for patients with advanced forms of the disease. Over the recent decades, the investigation of the pathophysiological mechanisms of tumourigenesis has opened promising avenues to understand some of the complexities of cancer treatment. However, tumour regeneration and metastasis impose great difficulty for gastric cancer cure. In recent years, cancer stem cells – a small subset of tumour cells in many cancers – have become a major focus of cancer research. Cancer stem cells are capable of self-renewal and are known to be responsible for tumour initiation, metastasis, therapy resistance and cancer recurrence. Recent studies have revealed the key role of microRNAs – small noncoding RNAs regulating gene expression – in these processes. MicroRNAs play crucial roles in the regulation of a wide range of biological processes in a post-transcriptional manner, though their expression is dysregulated in most malignancies, including gastric cancer. In this article, we review the consequences of aberrant expression of microRNA-34 in cancer and cancer stem cells, with a specific focus on the miR-34 dysregulation in gastric cancer and gastric cancer stem cells. We address the critical effects of the aberrant expression of miR-34 and its target genes in maintaining cancer stem cell properties. Information collection and discussion about the advancements in gastric cancer stem cells and microRNAs can be useful for providing novel insights into patient treatment.

10.1177/1010428317701652

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Epidermal Growth Factor Receptor Gene Polymorphisms and Gastric Cancer in Iran

Asian Pacific Journal of Cancer Prevention (2013)

Saeid Abediankenari Fereshteh Jeivad

Background: Epidermal growth factor receptor (EGFR) is a transmembrane receptor which contributes to many processes involved in cell survival, proliferation and inhibits apoptosis, that may lead to cancer development. Gastric cancer is one of the most common diseases of digestive system that has low 5-year-survival. The aim of this research was to determine the significance of EGFR tyrosine kinase domain gene polymorphisms in gastric cancer in Iran. Materials and Methods: In the present study, 83 patients with gastric cancer and 40 normal subjects were investigated for EGFR gene polymorphisms in exons 18-21 by PCR-SSCP. Then, DNA sequencing was conducted for different mobility shift bands. Finally the data were statistically analyzed using the chi-2 test and the SPSSver.16 program. Results: Exon 18 of EGFR gene showed three different bands in SSCP pattern and DNA sequencing displayed one mutation. SSCP pattern of Exons 19 and 21 did not show different migration bands. Exon 20 of EGFR gene revealed multiple migrate bands in SSCP pattern. DNA sequencing displayed 2 mutations in this exon: one mutation was caused amino acid change and another mutation was silent. Conclusion: It may be that EGFR tyrosine kinase gene polymorphisms differ between populations and screening could be useful in gastric cancer patients who might benefit from tyrosine kinase inhibitor therapy.

Single-strand conformation polymorphism

10.7314/apjcp.2013.14.5.3187

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Advanced Technologies in DNA-based Nanomedicine

Recent Advances in Drug Delivery and Formulation (2021)

Ameneh Mohammadi Pooria Gill Pedram Ebrahimnejad Saeid Abediankenari Zahra Kashi

: The application of nanotechnology in medicine and pharmaceutical purpose suggested a novel procedure in the nanotechnology terminology as nanomedicine. There is a wide range of applications for nanotechnology in medicine, such as the use of nanocarriers in drug delivery systems. Recently a remarkable attention to DNA has been made through its amazing functionality and its nature as a nanomaterial in biological systems. Since DNA is a biocompatible, the use of DNA as a nanomaterial in medicine has shown a great perspective of rational engineering of DNA nanostructures. According to new approaches in treatment of diseases in gene levels, gene therapy, using DNA as a nanomedicine possesses an important role in the medical sciences as the researchers published enormous papers and patents in the fields, for instance, the applications of DNA and DNA-based nanostructures as drug or gene nanocarriers, DNA-based diagnostics and DNA nanovasccines. Here, some examples of DNA-based nanomedicine in the patent frame were reviewed.

Nanocarriers

10.2174/2667387815666210212142526

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The Upregulation of HLA-G1 and miRNA-34a in Lens Epithelial Cells of Diabetic Retinopathy Patients.

PubMed (2023)

Elnaz Taghvaei-Bijandi Fatemeh Abedian Ahmad Ahmadzadeh Amiri Narjes Jafari Saeid Abediankenari

Retinopathy of diabetes is a chronic diabetes mellitus complication affecting retinal vessels, and some ocular complications' molecular mechanisms remain obscure.To evaluate the expression of HLA-G1, HLA-G5, miRNA-181a, and miRNA-34a in the lens epithelial cells of patients with retinopathy of diabetes.In a case-control study, 30 diabetic patients with retinopathy, 30 diabetic patients without retinopathy, and 30 cataract patients without diabetes mellitus as the control group were enrolled after a full description with details about the study methods and objectives. The expression of HLA G1, HLA G5, miRNA-181a, and miRNA-34a in lens epithelial cells was assessed by quantitative RT PCR. Moreover, the levels of HLA-G protein in aqueous humor were evaluated by the ELISA method.HLA-G1 expression was significantly upregulated in the retinopathy group (P=0.003). The aqueous humor of diabetic retinopathy patients contained significantly higher levels of HLA-G protein compared with the non-diabetic patients (P=0.001). miRNA-181a was significantly downregulated in the diabetic retinopathy group compared with the patients without diabetes (P=0.001). In addition, miRNA-34a was upregulated in the retinopathy group (P=0.009).Taken together, the present results showed that HLA-G1 and miRNA-34a can be valuable markers for diabetic retinopathy. Our data offers new perspectives for improving the control of inflammation in the lens epithelial cells by considering HLA-G and miRNA.

10.22034/iji.2023.97403.2510

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THE CONCURRENT EFFECT OF 5-AZACYTIDIN AND DMSO ON IN VITRO DIFFERENTIATION INDUCTION OF CARDIOMYOCYTES FROM EMBRYONIC CARCINOMA CELLS P19

Hatef Ghasemi Hamidabadi Nourollah Rezaei Raha Setorg Saeid Abediankenari Mostafa Latifpour

P19 cell

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Serum total carbohydrates, conjugated carbohydrates and total protein glycation index in diabetes mellitus

Glycoconjugate Journal (2023)

Sepideh Hosseini Saeid Abediankenari Mehdi Rasouli

10.1007/s10719-023-10115-w

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Effect of conditioned medium from miRNA-34a transfected gastric cancer-associated fibroblast on peripheral blood mononuclear cells

BMC Immunology (2025)

Mozhgan Esmaili Narjes Jafari Fatemeh Ahmadzadeh Shirin Toosi Saeid Abediankenari

Cancer-associated fibroblast (CAF) cells play an important role in gastric malignancy. MiRNA dysregulation has been detected in CAF cells, which is related to the tumor progression ability of these cells. Therefore, this study aimed to evaluate the function of miRNA34a in CAF cells in gastric carcinoma. We transiently transfected miRNA-34a mimic in CAF cells and examined the effect of the overexpressed miRNA on PD-L1 expression using real-time PCR. Next, we evaluated the role of transfected CAF-conditioned medium (CM) on the immune response and viability of gastric cancer cell lines. We have shown that miRNA-34a significantly reduced PD-L1 expression in CAF cells (p < 0.05). However, the conditioned medium of transfected cells had no significant effect on the immune response. We also found that CM of miRNA-34a transfected CAF cells significantly suppressed gastric cancer cell line viability relative to the control group (P < 0.05). We indicated that CM of miRNA-34a transfected CAF can reduce gastric cancer cell line proliferation. Additionally, miRNA-34a in these cells may improve immune response via PD-L1 reduction. Thus, miRNA-34a could be a potential therapeutic agent in gastric cancer treatment. Not applicable.

10.1186/s12865-025-00688-6

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^99mTc‐(EDDA/tricine)‐HYNIC‐GnRH analogue as a potential imaging probe for diagnosis of prostate cancer

Chemical Biology & Drug Design (2020)

Arezou Masteri Farahani Fariba Maleki Nourollah Sadeghzadeh Saeid Abediankenari Seyed Mohammad Abedi

Prostate cancer is a serious threat to men's health, so it is necessary to develop the techniques for early detection of this malignancy. Radiolabeled peptides are the useful tools for diagnosis of prostate cancer. In this research, we designed a new HYNIC-conjugated GnRH analogue and labeled it by 99m Tc with tricine/EDDA as coligands. We used aminohexanoic acid (Ahx) as a hydrocarbon linker to generate 99m Tc-(tricine/EDDA)-HYNIC-Ahx-[DLys6 ]GnRH. The radiopeptide exhibited high radiochemical purity and stability in solution and serum. Two human prostate cancer cell lines LN-CaP and DU-145 were used for cellular experiments. The binding specificity and affinity of radiopeptide for LN-CaP were superior to DU-145 cells. The Kd values for LN-CaP and DU-145 cells were 41.91 ± 7.03 nM and 55.96 ± 10.56 nM, respectively. High kidney uptake proved that the main excretion route of radiopeptide was through the urinary system. The tumor/muscle ratio of 99m Tc-HYNIC-Ahx-[DLys6 ]GnRH was 4.14 at 1 hr p.i. that decreased to 2.41 at 4 hr p.i. in LN-CaP tumor-xenografted nude mice. The blocking experiment revealed that the tumor uptake was receptor-mediated. The lesion was visualized clearly using 99m Tc-[DLys6 ]GnRH at 1 hr p.i. Accordingly, this research highlights the capability of 99m Tc-(tricine/EDDA)-HYNIC-Ahx-[DLys6 ]GnRH peptide as a promising agent for GnRHR-expressing tumor imaging.

Tricine

10.1111/cbdd.13693

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Investigation of Relationship between Hepatitis B Virus and Gastric Adenocarcinoma.

PubMed (2012)

Mohammad‐Reza Ghasemi Vahedi Larijani L Saeid Abediankenari

Dear Editor, Gastric cancer is the second leading cause of cancer-related deaths worldwide [1][2][3] while some genetic and environmental factors such as infectious agents were shown to be linked to carcinogenesis.[2] Infectious agents notably viruses were shown to induce 20-25% of all cancers around the globe.[4][5] Helicobacter pylori (H. pylori) is one of those infectious agents to be related to gastric carcinogenesis.[1][2] Epstein bar virus was inconstantly demonstrated to be associated with gastric cancer that may be due to the presence of the cofactor of H. pylori that can immortalize abnormal epithelial cells.[6] Hepadnaviridae, the most powerful infectious related cause of hepatoma has been reported with other malignancies such as renal cell carcinoma, gastric and oral cancers.[7][8][9] One study showed an association between anti-hepatitis C virus (HCV) antibody in 10.6% of sera of patients and gastric cancer.[10] Gastric cancer is assumed to be more prevalent in cirrhotic patients.[9] Expression of hepatitis B virus (HBV) antigens in H. pylori bearing gastric mucosa was shown by immunostaining methods.[11] Here we evaluated the association between HBV infection and gastric carcinoma in north of Iran. We collected one hundred formalin-fixed paraffin embedded blocks of biopsies confirmed as gastric cancer in pathology department of our university belonging to patients who underwent gastrectomy during 2005-2010. Besides, 100 blocks of normal gastric mucosa tissues were provided as control group. Polymerase chain reaction for HBV DNA detection was performed. Sixty nine percent of gastric cancer patients were male (Male/female ratio: 69/31) with a mean age of 67.14±10.98 years. The most common histological type of adenocarcinoma was intestinal type (68%) followed by diffuse (26%) and mixed (7%) types while the location was respectively proximal (57%), distal (22%) and diffuse (6%). The majority patients were diagnosed at advanced stage III (68%) followed by stage 2 (19%), stage 4 (9%) and stage 1 (4%). The most common grade was grade 2 (52%), grade 1 (41%) and grade 3 (7%). HBV genome was undetectable in all cases and control subjects using PCR (Figure 1). Fig. 1 Agarose gel electrophoresis illustrated a positive control for patients DNA (Beta actin as house keeping gene) compared to negative gastric cancer cases. 1: DNA ladder (50 bp-1000bp), 2, 3, 4, 5, 6, 7: Beta actin (321 bp), 8: Negative con-trol. Previous studies confirmed the role of HBV in the pathogenesis of hepatocellular carcinoma.[4][5] Besides, limited studies have revealed association between HBV antigens and/or antibodies with other malignancies such as renal carcinoma, oral cancer, and gastric carcinoma.[7][8][9][10] Zullo et al. showed 2.6 folds increases in prevalence of gastric cancer in cirrhotic patients compared to non-cirrhotic individuals using endoscopic and histological examinations.[9] Chen et al. showed the expression of HBV antigens in H. pylori infected gastric mucosa of patients with chronic liver disease using immunostaining.[11] Our findings showed that HBV genome was undetectable in gastric cancers. We demonstrated that HBV was not correlated with gastric carcinoma in north of Iran.

CagA

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