Lynn X. Zhang

Clemson University

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R. Kenneth Marcus

Clemson University

Benjamin T. Manard

Oak Ridge National Laboratory

Julia L. Brumaghim

Clemson University

Amanda M. Owen

Clemson University

Caleb M. Cohen

Clemson University

Stefanie Konegger-Kappel

International Atomic Energy Agency

Rodrigo Castro-Ramírez

Universidad Nacional Autónoma de México

Haydan C. Smith

Clemson University

Craig A. Bayse

Old Dominion University

Bradley S. Stadelman

Clemson University

Cooperative Institutions

Clemson University

University of California, Berkeley

Lawrence Berkeley National Laboratory

National Institute of Standards and Technology

National Institute of Standards

Material Measurement Laboratory

Berkeley College

University of California System

Savannah River National Laboratory

Oak Ridge National Laboratory

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Liquid sampling-atmospheric pressure glow discharge excitation of atomic and ionic species

Journal of Analytical Atomic Spectrometry (2014)

Stefanie Konegger-Kappel Benjamin T. Manard Lynn X. Zhang Thomas Konegger R. Kenneth Marcus

Inter-parametric evaluation of the production of excited atomic and ionic states in the LS-APGD microplasma is presented.

Glow discharge

10.1039/c4ja00302k

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Citations (16)

CCDC 1852325: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Bradley S. Stadelman Jaime M. Murphy Amanda M. Owen Rodrigo Castro-Ramírez Haydan C. Smith

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc205hf4

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Citations (0)

Investigation of spectrochemical matrix effects in the liquid sampling-atmospheric pressure glow discharge source

Spectrochimica Acta Part B Atomic Spectroscopy (2014)

Benjamin T. Manard Jhanis J. González Arnab Sarkar Xianglei Mao Lynn X. Zhang

Glow discharge

Excitation temperature

Vaporization

10.1016/j.sab.2014.08.006

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Citations (11)

Parallel, open-channel lateral flow (immuno) assay substrate based on capillary-channeled polymer films

The Analyst (2015)

Lynn X. Zhang Liuwei Jiang Daniel Willett R. Kenneth Marcus

Presented here is a novel implementation of polypropylene capillary-channeled polymer (C-CP) films, functionalized for bioaffinity separations and implemented as a platform for lateral flow (immuno) assays. The parallel ∼80 μm × 80 μm channels pass test solutions down the 30 mm film length via spontaneous wicking action, setting up the possibility for immobilizing different capture agents in the respective channels. The base-film modification process is divided into two steps: ultraviolet light treatment to improve hydrophillicity of the polypropylene substrate and the physical adsorption of a functionalized lipid tethered ligand (LTL) as a selective capture agent. The entire modification procedure is performed under ambient conditions in an aqueous solution without extreme pH conditions. In this demonstration, physical adsorption of a biotinylated-LTL onto the UV-treated PP surface selectively captures Texas Red-labeled streptavidin (SAv-TR) in the presence of enhanced green fluorescence protein (EGFP), which passes without retention in less than 5 s. In addition to the fluorescence imaging of the protein solutes, matrix assisted laser desorption/ionization-mass spectrometry (MALDI-MS) was used to confirm the formation of the LTL-SAv conjugates on the channel surface as well as to demonstrate an alternative means of probing the capture step. The present effort sets the groundwork for further development of C-CP films as a parallel, multi-analyte LFA platform; a format that to-date has not been described.

10.1039/c5an01953b

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Citations (1)

Determination of Isoflavone Content in SRM 3238 Using Liquid Chromatography-Particle Beam/Electron Ionization Mass Spectrometry

Journal of AOAC International (2015)

Lynn X. Zhang Carolyn Q Burdette Melissa Phillips Catherine A. Rimmer R. Kenneth Marcus

Abstract The characterization of marker components in botanical materials is a challenging task, and the increased consumption of botanicals and dietary supplements demands a greater understanding of the associated health benefits and risks. In order to successfully acquire and compare clinical results and correlate health trends, accurate, precise, and validated methods of analysis must be developed. Presented here is the development of a quantitative method for the determination of soy isoflavones (daidzin, glycitin, genistin, daidzein, and genistein) using LC-particle beam/electron ionization-MS (LC-PB/EIMS). An internal standard (IS) approach for quantitation with 7-hydroxy-4- chromone as the IS compound was used, with response factors for each individual isoflavone obtained from calibrant solutions. The results from this method were compared with the certified and reference values for National Institute of Standards and Technology (NIST) SRM 3238 Soy-Containing Solid Oral Dosage Form to demonstrate that the method was in control. Results obtained using LC-PB/EIMS were consistent with the NIST certified or reference values and their uncertainties for all five isoflavones, demonstrating that the LC-PB/EIMS approach is both accurate and precise when used for the determination of the target isoflavones in soy-containing dietary supplement finished products while simultaneously providing structural information.

Genistin

Daidzin

Certified reference materials

Soy Isoflavones

10.5740/jaoacint.15-112

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Citations (8)

Ambient desorption/ionization mass spectrometry using a liquid sampling–atmospheric glow discharge (LS-APGD) ionization source

Analytical and Bioanalytical Chemistry (2013)

R. Kenneth Marcus Carolyn Q Burdette Benjamin T. Manard Lynn X. Zhang

Glow discharge

Ambient ionization