Haoyi Lei

University of Washington

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Warren Ladiges

University of Washington

Juan Wang

Anhui University of Traditional Chinese Medicine

Sarah Fish

University of California Davis Medical Center

Rahul K. Chaliparambil

Northwestern University

Steve Austad

University of Alabama at Birmingham

Susan M. Markiewicz

University of Washington

Christy S. Carter

National Institute on Aging

Derek M. Huffman

Albert Einstein College of Medicine

Y J Wu

Yangzhou University

Anushka Noori

Bellevue College

Cooperative Institutions

University of Washington

Bellevue College

The University of Texas Health Science Center at San Antonio

Geriatric Research Education and Clinical Center

Seattle University

Shanxi Medical University

University of Alabama at Birmingham

National Institute on Aging

South Texas Veterans Health Care System

The University of Texas at San Antonio

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Resilience to aging is a heterogeneous characteristic defined by physical stressors

Aging Pathobiology and Therapeutics (2022)

Haoyi Lei Derek M. Huffman Adam B. Salmon Nathan K. LeBrasseur Christy S. Carter

Physical resilience, the capacity to respond to and recover from a stressful event, declines with advancing age. Individuals respond differently to physical stressors across their lifespans. While the biological underpinnings of resilience remain unclear, a plausible determinant is the capacity of an individual’s cellular and molecular levels to return to homeostasis after a physical challenge. Impaired resilience may not only be a consequence of aging but could also be a contributing factor to the aging process. Therefore, resilience at relatively younger ages could be predictive of future health and lifespan. By utilizing standardized physical challenges and measuring stress response patterns, the relative resilience of individuals can be quantified and classified. Current preclinical research suggests that several physical stressors could be used to measure resilience in clinical aging studies. A mechanistic understanding of why some individuals are more resilient to physical stressors than others could help identify protective factors and therapeutic ways to promote healthy aging. Keywords: Physical resilience to aging, physical stressors, heterogeneity, stress response patterns, healthy aging, therapeutic resilience

Stressor

Resilience

10.31491/apt.2022.03.076

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Citations (8)

Androst-4-ene-3 beta, 17 beta-diol dicyclopentylpropionate combined with traditional Chinese drugs in chronic aplastic anemia.

PubMed (1981)

Z N Zhang Y J Wu Yanjuan Hou Haoyi Lei Q Q Chen

Aplastic anemia

BETA (programming language)

Ene reaction

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Short-term oral rapamycin prevents age-related learning impairment in mice

Aging Pathobiology and Therapeutics (2020)

Haoyi Lei Juan Wang Warren Ladiges Zhou Jiang

Effective treatments to prevent or delay age-related learning impairment are not generally available. In a preliminary preclinical study, mice 20 months of age were fed a diet containing 14 ppm rapamycin, an inhibitor of mTOR, for three months and then tested in a spatial navigation task. Mice fed the nonmedicated control diet showed learning impairment while mice fed the rapamycin diet were not learning impaired. This observation provides support for additional preclinical studies and suggests that short-term rapamycin treatment could be a possible strategy for preventing or delaying age-related cognitive impairment in people. Keywords: Age-related learning impairment, rapamycin, aging mice

Sirolimus

10.31491/apt.2020.09.033

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[THE STIMULATION OF THE RELEASE OF ACTH BY CORYDALIS B IN RATS].

PubMed (1963)

K T Liu Haoyi Lei

Corydalis B has been reported to have strong analgesic and sedative actions resembling morphine and a number of tranquilizers. It is well.known that both morphine and the tranquilizers, such as reserpine and chlorpromazine, stimulate the release of ACTH, as well as depress the secretion of ACTH by the pituitary in response to a number of stressful stimuli under certain conditions. Since Corydalis B has been shown to have pharmacological properties similar to those of the aforementioned compounds, an attempt was made to study whether corydalis B would also affect the pituitary-adrenal axis. Experiments were carried out on male rats. A fall in adrenal ascorbic acid was used as the criterion for the release of ACTH. Subcutaneous injection of Corydalis B in a dose of 50 or 70mg/kg, the effective analgesic and sedative dosage, caused marked adrenal ascorbic acid and cholesterol depletion in intact rats. However, the ascorbic acid depleting effect of the compound disappeared in hypophysectomized rats. Pretreatment of rats with pentobarbital (40 mg/kg) or prednisolone (15 mg/kg) completely prevented the adrenal ascorbic acid depletion. Repeated injections of Corydalis B for 6 days, induced the development of tolerance to the pituitary-stimulating effect of the compound. From these results, it would appear that Corydalis B has a stimulatory action on the pituitary-adrenal system.

Reserpine

Subcutaneous injection

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Packing entropy for fixed-point free flows

arXiv (Cornell University) (2021)

Liang Ruiming Haoyi Lei

Let $(X,ϕ)$ be a compact flow without fixed points. We define the packing topological entropy $h_{\mathrm{top}}^P(ϕ,K)$ on subsets of $X$ through considering all the possible reparametrizations of time. For fixed-point free flows, we prove the following result: for any non-empty compact subset $K$ of $X$, $$h_{\mathrm{top}}^P(ϕ,K)=\sup\{\overline{h}_μ(ϕ):μ(K)=1,μ\text{ is a Borel probability measure on} X\},$$ where $\overline{h}_μ(ϕ)$ denotes the upper local entropy for a Borel probability measure $μ$ on $X$.

10.48550/arxiv.2102.10281

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Generation and characterization of a tractable C. elegans model of tauopathy

GeroScience (2021)

Joshua C. Russell Haoyi Lei Rahul K. Chaliparambil Sarah Fish Susan M. Markiewicz

Tauopathy

Tau protein

Hyperphosphorylation

10.1007/s11357-021-00436-9

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Citations (3)