Wolfgang Bäumler

University Hospital Regensburg

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Michael Landthaler

University Hospital Regensburg

M. Landthaler

University Hospital Regensburg

Tim Maisch

University Hospital Regensburg

Christoph Abels

Dr. August Wolff (Germany)

Rolf‐Markus Szeimies

Klinikum Vest

Ulrich Hohenleutner

University Hospital Regensburg

Sigrid Karrer

University Hospital Regensburg

Johannes Regensburger

University Hospital Regensburg

Rudolf Vasold

University of Regensburg

Burkhard König

University of Regensburg

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University of Regensburg

164

University Hospital Regensburg

Ludwig-Maximilians-Universität München

Heidelberg University

University Medical Center

Charité - Universitätsmedizin Berlin

University Hospital Heidelberg

Universität Hamburg

Hautklinik Heidelberg

University of Lübeck

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通过光动力治疗实现人皮肤的 MRSA 非殖民化治疗

British Journal of Dermatology (2018)

M. Schreiner Wolfgang Bäumler Daniel Bernhard Eckl Andreas Späth Brigitte König

作为医院感染的来源之一, 患者皮肤表面(载体)存在潜在有害细菌, 它们不会产生感染, 但在某些条件下可能传播给其他人。皮肤表面生活的细菌也会导致湿疹恶化。目前去除这些微生物(细菌)皮肤的方法包括给患者使用局部抗生素(皮肤上的)或口服抗生素(口服),但随着时间的推移, 这种策略被认为导致了抗生素耐药性, 这意味着抗生素不再能杀死细菌。本文中描述的是由德国雷根斯堡大学的一个小组进行的研究。他们使用切掉的猪和人体皮肤样本, 在样本中加入耐药细菌,如耐甲氧西林葡萄球菌或 MRSA, 然后用一种化学溶液对皮肤进行处理, 这种化学溶液的作用是增加对光的敏感性。皮肤样本随后暴露在光源下,这一过程被称为光动力激活。他们发现这种技术可以在不损害皮肤细胞的情况下, 大量减少细菌的数量。作者建议,这一过程现在应该作为一种更安全的方法来研究, 以减少表面细菌运输, 而不增加细菌耐药性的风险,也不损害皮肤。

10.1111/bjd.17302

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Citations (0)

Tattoo-Entfernung mit dem Laser

MMW - Fortschritte der Medizin (2006)

Wolfgang Bäumler Michael Landthaler

10.1007/bf03364783

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Citations (6)

Femtosecond pulse generation around 650 nm in a passive mode-locked Kiton Red dye laser

Optics Communications (1993)

Valentin Petrov M. Wittmann Wolfgang Bäumler A. Penzkofer

Pulse duration

Saturable absorption

Femtosecond pulse

Mode-Locking

10.1016/0030-4018(93)90053-8

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Citations (3)

Photodynamic Inactivation of Staphylococci with 5-Aminolaevulinic Acid or Photofrin

Lasers in Medical Science (1999)

Sigrid Karrer Rolf‐Markus Szeimies Sharon L. Ernst Christoph Abels Wolfgang Bäumler

10.1007/s101030050021

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Citations (30)

Tätowierungspigmente im Fokus der Forschung

Nachrichten aus der Chemie (2007)

Eva Engel Rudolf Vasold Wolfgang Bäumler

Abstract Eine Tätowierung oder ein Permanent‐Make‐up wie tätowierter Lidstrich und Lidschatten ist meist eine Entscheidung fürs Leben. Die Farbpigmente, die beim Tätowieren in die Haut eingebracht wurden, wieder zu entfernen, ist nicht nur kostenaufwendig und schmerzhaft, sondern manchmal sogar gesundheitsgefährlich.

10.1002/nadc.200751916

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Citations (8)

Laser- und Lichttherapie von kapillären Malformationen (Nävi flammei)

Aktuelle Dermatologie (2013)

A. Кlеіn Wolfgang Bäumler

Kapilläre Malformationen (Nävi flammei) werden bei unter 1 % der Neugeborenen beobachtet. Sie treten überwiegend im Kopf-Hals-Bereich auf und können sehr stigmatisierend für die Betroffenen sein. Blitzlampen-gepumpte gepulste Farbstofflaser stellen weiterhin die Therapie der Wahl dar und können bereits im Säuglingsalter eingesetzt werden. Aber auch inkohärente Lichtquellen wie die Hochenergetische Blitzlampe (HBL) werden zunehmend erfolgreich eingesetzt. Während bei den meisten Patienten eine gute Aufhellung des Nävus flammeus durch die Laser- oder HBL-Therapie erzielt werden kann, wird nur selten ein komplettes Verschwinden der Läsion erreicht. Daher wären neue, effektivere Therapieoptionen wünschenswert.

10.1055/s-0033-1344223

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Adverse Reactions after Tattooing: Review of the Literature and Comparison to Results of a Survey

Dermatology (2013)

S. Wenzel Ines Rittmann Michael Landthaler Wolfgang Bäumler

The number of tattooed people has substantially increased in the past years. Surveys in different countries reveal this to be up to 24% of the population. The number of reported adverse reactions after tattooing has also increased including infections, granulomatous and allergic reactions and tumors. However, the case reports do not reflect the frequency of adverse reactions. This review compares the medically documented adverse reactions published in 1991-2011 with the findings of a nation-wide survey that recently revealed the features and health problems associated with tattoos. To compare the data with the survey, the sex of patients was reported and the location and color of tattoos were evaluated. The results show clearly that colored tattoo inks are mainly responsible for adverse skin reactions and that tattoos on the extremities are involved most.

Skin reaction

10.1159/000346943

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Citations (129)

Laser tattoo removal: do we already have picosecond lasers?

JDDG Journal der Deutschen Dermatologischen Gesellschaft (2018)

Syrus Karsai Wolfgang Bäumler Christel Weiß Jörg Faulhaber Christian Raulin

10.1111/ddg.13467

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Citations (7)

Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma

British Journal of Cancer (1998)

Christoph Abels Sigrid Karrer Wolfgang Bäumler A. E. Goetz M. Landthaler

Indocyanine Green

Erythema

Kaposi's sarcoma

10.1038/bjc.1998.168

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Citations (76)

Fast and Effective Photodynamic Inactivation of Multiresistant Bacteria by Cationic Riboflavin Derivatives

PLoS ONE (2014)

Tim Maisch Anja Eichner Andreas Späth Anita Gollmer Burkhard König

Photodynamic inactivation of bacteria (PIB) proves to be an additional method to kill pathogenic bacteria. PIB requires photosensitizer molecules that effectively generate reactive oxygen species like singlet oxygen when exposed to visible light. To allow a broad application in medicine, photosensitizers should be safe when applied in humans. Substances like vitamin B2, which are most likely safe, are known to produce singlet oxygen upon irradiation. In the present study, we added positive charges to flavin derivatives to enable attachment of these molecules to the negatively charged surface of bacteria. Two of the synthesized flavin derivatives showed a high quantum yield of singlet oxygen of approximately 75%. Multidrug resistant bacteria like MRSA (Methicillin resistant Staphylococcus aureus), EHEC (enterohemorrhagic Escherichia coli), Pseudomonas aeruginosa, and Acinetobacter baumannii were incubated with these flavin derivatives in vitro and were subsequently irradiated with visible light for seconds only. Singlet oxygen production in bacteria was proved by detecting its luminescence at 1270 nm. After irradiation, the number of viable bacteria decreased up to 6 log10 steps depending on the concentration of the flavin derivatives and the light dosimetry. The bactericidal effect of PIB was independent of the bacterial type and the corresponding antibiotic resistance pattern. In contrast, the photosensitizer concentration and light parameters used for bacteria killing did not affect cell viability of human keratinocytes (therapeutic window). Multiresistant bacteria can be safely and effectively killed by a combination of modified vitamin B2 molecules, oxygen and visible light, whereas normal skin cells survive. Further work will include these new photosensitizers for topical application to decolonize bacteria from skin and mucosa.

Acinetobacter baumannii

10.1371/journal.pone.0111792

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Citations (114)