Manoj Kumar Muthyala

The first immobilization of a MacMillan's first generation organocatalyst onto dendritic support is described. A modified tyrosine-based imidazolidin-4-one was grafted to a soluble high-loading hyperbranched polyglycerol via a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction and readily purified by dialysis. The efficiency of differently functionalized multivalent organocatalysts 4a-c was tested in the asymmetric Friedel-Crafts alkylation of N-methylpyrrole with α,β-unsaturated aldehydes. A variety of substituted enals was investigated to explore the activity of the catalytic system which was also compared with monovalent analogues. The catalyst 4b showed excellent turnover rates and no loss of activity due to immobilization, albeit moderate enantioselectivities were observed. Moreover, easy recovery by selective precipitation allowed the reuse of the catalyst for three cycles.

Friedel–Crafts reaction

Alkyne

10.3762/bjoc.11.83

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Citations (15)

ChemInform Abstract: Advances in Functionalized Ionic Liquids as Reagents and Scavengers in Organic Synthesis

ChemInform (2015)

Manoj Kumar Muthyala Kavya Velisetti Keykavous Parang Anil Kumar

10.1002/chin.201517292

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Citations (1)

Imidazolium salt-supported Mukaiyama reagent: an efficient condensation reagent for amide bond formation

RSC Advances (2015)

Khima Pandey Manoj Kumar Muthyala Sunita Choudhary Anil Kumar

A novel imidazolium salt-supported Mukaiyama reagent has been synthesized and utilized as a coupling agent for the synthesis of amides.

Amide

Peptide bond

Condensation reaction

Salt lake

10.1039/c4ra14856h

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Advances in Functionalized Ionic Liquids as Reagents and Scavengers in Organic Synthesis

Current Organic Chemistry (2014)

Manoj Kumar Muthyala Kavya Velisetti Keykavous Parang Anil Kumar

Functionalized ionic liquids (FILs) synthesized with specific desired chemical properties have shown promising results in various areas of organic synthesis. In supported organic synthesis, FILs have become known as a new alternative to commonly used PEG and fluorous soluble supports. This review summarizes the progress of recent development in the synthesis of functionalized ionic liquids with emphasis on their applications as reagents and scavengers in organic synthesis. Keywords: Functionalized ionic liquid, ionic liquid, reagents, scavenger and soluble support, supported reagents.

Organic Synthesis

Scavenger

10.2174/138527281819141028114639

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Ionic-liquid-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene — An efficient and recyclable organocatalyst for Michael addition to α,β-unsaturated ketones

Canadian Journal of Chemistry (2012)

Manoj Kumar Muthyala Bhupender S. Chhikara Keykavous Parang Anil Kumar

A novel ionic-liquid-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene (IL–TBD) was synthesized and investigated for its ability to act as an active organocatalyst in the Michael addition of active methylene compounds and thiophenols to chalcones under solvent-free conditions. The IL–TBD afforded Michael addition products in excellent yields (82%–94%) at room temperature, and it was simply recycled and reused at least five times without significant loss of catalytic activity.

Michael reaction

Ene reaction

Methylene

10.1139/v11-162

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ChemInform Abstract: Ionic Liquid Phase Synthesis (IoLiPS) of 2‐Aminothiazoles and Imidazo[1,2‐a]pyridines.

ChemInform (2015)

Sunita Choudhary Manoj Kumar Muthyala Anil Kumar

Abstract Acetophenones (I) give title compounds (III) or (V) upon reaction with either thiourea (II) or 2‐aminopyridine (IV) in the presence of ionic liquid‐supported hypervalent iodine compound ILI.

Hypervalent molecule

10.1002/chin.201514034

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Manoj Kumar Muthyala

Papers

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H-Index

i-10 index

Papers

Citation

H-Index

i-10 index