Yrna Lorena Matos de Oliveira

Universidade Federal de Sergipe

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Silvio Santana Dolabella

Universidade Federal de Sergipe

Yvanna Louise Di Christine Oliveira

Universidade Federal de Sergipe

Lilian Lacerda Bueno

Universidade Federal de Minas Gerais

Ayane de Sá Resende

Universidade de São Paulo

Anne Caroline Santos Ramos

Universidade Federal de Sergipe

Ricardo Toshio Fujiwara

Universidade Federal de Minas Gerais

Luciana Maria de Oliveira

Universidade Federal do Ceará

Cristiane Bani Corrêa

Universidade Federal de Sergipe

Ricardo M. Geraldi

Universidade Federal de Minas Gerais

Paulo Ricardo Martins‐Filho

Universidade Federal de Sergipe

Cooperative Institutions

Universidade Federal de Sergipe

Universidade Tiradentes

Universidade Federal de Minas Gerais

Fundação Oswaldo Cruz

Faculdades Guarulhos

Instituto de Tecnologia e Pesquisa

Universidade Federal do Rio Grande do Sul

Universidade de São Paulo

Universidade Federal de Alagoas

University of Vienna

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Nisin Induces Cell-Cycle Arrest in Free-Living Amoebae Acanthamoeba castellanii

Acta Parasitologica (2021)

Marianna de Carvalho Clímaco Yrna Lorena Matos de Oliveira Anne Caroline Santos Ramos Jucicleide Ramos-de-Souza Audrey Rouse Soares Tavares Silva

10.1007/s11686-021-00436-x

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Citations (6)

Dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in the Northeast region of Brazil

Pathogens and Global Health (2022)

Adriano Antunes de Souza Araújo Lucindo José Quintans‐Júnior Luana Heimfarth Dulce Marta Schimieguel Cristiane Bani Corrêa

In this household-based seroepidemiological survey, we analyzed the dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in Sergipe State, Northeast Brazil, the poorest region of the country. A total of 16,547 individuals were tested using a rapid IgM-IgG antibody test and fluorescence immunoassay (FIA). Seroprevalence rates were presented according to age, sex, and geographic region. A comparative analysis was performed between the results obtained in July 2020 (peak of the first wave), August - November 2020 (end of the first wave), and February - March 2021 (beginning of the second wave). Seroprevalence rates in the three phases were estimated at 9.3% (95% CI 8.5-10.1), 12.0% (95% CI 11.2-12.9) and 15.4% (95% CI 14.5-16.4). At the end of the first wave, there was a rise in seroprevalence in the countryside (p < 0.001). At the beginning of the second wave, we found an increase in seroprevalence among women (p < 0.001), adults aged 20 to 59 years (p < 0.001), and the elderly (p < 0.001). In this phase, we found an increase in estimates both in metropolitan areas and in the countryside (p < 0.001). This study showed an increase in SARS-CoV-2 seroprevalence over the first year of the pandemic, with approximately one in six people having anti-SARS-CoV-2 antibodies at the beginning of the second wave of COVID-19. Furthermore, our results suggest a rapid spread of COVID-19 from metropolitan areas to the countryside during the first months of the pandemic.

Seroprevalence

Pandemic

10.1080/20477724.2022.2121366

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Occurrence, molecular diversity and pathogenicity of Acanthamoeba spp. isolated from aquatic environments of Northeastern Brazil

International Journal of Environmental Health Research (2022)

Yrna Lorena Matos de Oliveira Erica Tirzah Santos Lima Marilise Brittes Rott Roberta Pereira Miranda Fernandes Sona Jain

Acanthamoeba is a free-living amoeba (FLA) that is ubiquitous in nature and can cause serious pathologies in humans. This protozoan has been detected in several environmental sources, such as soil, water, and swimming pools. The aim of this study was to evaluate the occurrence and molecular diversity of Acanthamoeba spp. in aquatic environments of the state of Sergipe, northeastern Brazil, and to determine the pathogenic potential of the isolated samples. A total of 138 samples were collected from 69 aquatic environments and, after cell culture, 74% of the samples were positive for FLA, 47% belonging to the genus Acanthamoeba. Genotypic analysis was performed using the primers JDP1 and JDP2, confirming distinct Acanthamoeba genotypes: 18 (75%) isolates belonging to genotype T4, two (8%) to T3, and one isolate (4%) to genotype T5. Tests carried out to analyze the pathogenic potential showed that 11 isolates could grow at 0.5 M mannitol concentration and seven isolates supported hyperosmolarity. In the thermotolerance test, two isolates grew at 37°C. These results confirm the presence and the pathogenic potential of FLA of the genus Acanthamoeba in aquatic environments of the municipalities of Sergipe.

10.1080/09603123.2022.2117280

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Intestinal polyparasitism and levels of mucosal anthelmintic SIgA in children from endemic areas in Northeastern Brazil

Parasite Immunology (2021)

Luciana Maria de Oliveira Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Anne Caroline Santos Ramos Gabriela F. Andrade

Interactions between parasites during co-infections are often complex and can impact immunization and treatment programmes, as well as disease outcomes and morbidity. However, little is known about these interactions and the mechanisms involved. In this study, a coproparasitological survey was carried out in school-age children living in endemic areas of parasitic infection in the state of Sergipe, Northeastern Brazil. Anti-helminth-specific and total secretory immunoglobulin-A (SIgA) levels were measured in stool and saliva samples and were compared in children presenting monoparasitism, polyparasitism (helminths and/or intestinal protozoa) and no infections. The survey showed that protozoa were more prevalent than helminths, and that there was a high frequency of polyparasitism in the studied population, mainly from combinations of protozoan species. Although less frequent, combinations between species of protozoa and helminths were also observed. The levels of salivary SIgA in these co-infected individuals were lower than the average observed in infections with helminths alone. Although the children participating in this survey were asymptomatic, and it was, therefore, not possible to evaluate the impact of salivary SIgA reduction on the diseases, and the study highlights the need for further investigations of co-infections by intestinal parasites and the effects on immune response induced by the interactions between different parasites.

Trichuris

10.1111/pim.12899

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Obesity in Severe COVID-19 Patients Has a Distinct Innate Immune Phenotype

Biomedicines (2023)

Ayane de Sá Resende Yrna Lorena Matos de Oliveira Mariana Nobre Farias de Franca Lucas Sousa Magalhães Cristiane Bani Corrêa

Obesity alters the capacity of effective immune responses in infections. To further address this phenomenon in the context of COVID-19, this study investigated how the immunophenotype of leukocytes was altered in individuals with obesity in severe COVID-19. This cross-sectional study enrolled 27 ICU COVID-19 patients (67% women, 56.33 ± 19.55 years) that were assigned to obese (BMI ≥ 30 kg/m2, n = 9) or non-obese (BMI < 30kg/m2, n = 18) groups. Monocytes, NK, and both Low-Density (LD) and High-Density (HD) neutrophils were isolated from peripheral blood samples, and surface receptors’ frequency and expression patterns were analyzed by flow cytometry. Clinical status and biochemical data were additionally evaluated. The frequency of monocytes was negatively correlated with BMI, while NK cells and HD neutrophils were positively associated (p < 0.05). Patients with obesity showed a significant reduction of monocytes, and these cells expressed high levels of PD-L1 (p < 0.05). A higher frequency of NK cells and increased expression of TREM-1+ on HD neutrophils were detected in obese patients (p < 0.05). The expression of receptors related to antigen-presentation, phagocytosis, chemotaxis, inflammation and suppression were strongly correlated with clinical markers only in obese patients (p < 0.05). Collectively, these outcomes revealed that obesity differentially affected, and largely depressed, innate immune response in severe COVID-19.

Immunophenotyping

Immune Dysregulation

10.3390/biomedicines11082116

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Role of Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in COVID-19 and Other Viral Pneumonias: A Systematic Review and Meta-Analysis of Clinical Studies

SSRN Electronic Journal (2022)

Yrna Lorena Matos de Oliveira Ayane de Sá Resende Tatiana Rodrigues de Moura Paulo Ricardo Martins‐Filho

Background: Triggering receptor expressed on myeloid cells-1 (TREM-1) has emerged as an important inflammatory marker of immune response associated with severity and mortality outcomes in infection diseases, including viral pneumonias.Aim: (1) To evaluate the expression of TREM-1 in patients with COVID-19 and other viral pneumonias compared to healthy individuals; and (2) to analyze the levels of these biomarkers according to disease severity.Method: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Searches were performed in PubMed, Scopus, Embase, and Google Scholar. Studies were considered eligible if they were observational studies that provided data on the levels of TREM-1 in humans with viral pneumonia compared to healthy controls. The results of the meta-analysis were expressed as standardized mean difference (SMD) and an effect size of 0.8 was considered a large effect. A subgroup analysis was performed according to the disease severity.Results: Seven studies were included in this systematic review. Four studies included patients with COVID-19 and three analyzed patients with different viruses. The meta-analysis was performed only with patients with COVID-19, which showed increased levels of soluble form of TREM-1 among patients with COVID-19 compared to healthy controls (SMD 1.53; 95% CI 0.53 to 2.52; p < 0.01). No differences were found between patients with mild to moderate COVID-19 and healthy controls, but higher levels of sTREM-1 were shown among patients with severe COVID-19 (SMD 1.83; 95% CI 0.77 to 2.88; p < 0.01). All three studies evaluating including patients with other viral pneumonias showed that TREM-1 levels were significantly elevated in infected patients compared with controls.Conclusion: These findings may provide evidence on the pro-inflammatory role of TREM-1 in these infections, contributing to the inflammatory profile and disease progression.

2019-20 coronavirus outbreak

10.2139/ssrn.4019296

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Amoebicidal activity of essential oils and essential oil-based microemulsions of Aloysia citrodora Ortega ex Pers., Cymbopogon winterianus Jowitt ex Bor and Ocimum gratissimum L. against Acanthamoeba polyphaga trophozoites

Journal of Applied Microbiology (2024)

Ingrid Borges Siqueira Yrna Lorena Matos de Oliveira Bráulio Otomar Caron Denise Schmidt Audrey Rouse Soares Tavares Silva

Evaluate the in vitro efficacy of the essential oils derived from Aloysia citrodora (Verbenaceae), Cymbopogon winterianus (Poaceae), and Ocimum gratissimum (Lamiaceae) against Acanthamoeba polyphaga trophozoites. Additionally, microemulsions formulated with these essential oils, along with their major components, were analyzed.

Ocimum gratissimum

Verbenaceae

10.1093/jambio/lxae232

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Author response for "Intestinal polyparasitism and levels of mucosal anthelmintic SIgA in children from endemic areas in Northeastern Brazil"

Luciana Maria de Oliveira Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Anne Caroline Santos Ramos Gabriela F. Andrade

10.1111/pim.12899/v3/response1

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Author response for "Intestinal polyparasitism and levels of mucosal anthelmintic SIgA in children from endemic areas in Northeastern Brazil"

Luciana Maria de Oliveira Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Anne Caroline Santos Ramos Gabriela F. Andrade

10.1111/pim.12899/v2/response1

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Changes in the epidemiological profile of intestinal parasites after a school-based large-scale treatment for soil-transmitted helminths in a community in northeastern Brazil

Acta Tropica (2019)

Yvanna Louise Di Christine Oliveira Luciana Maria de Oliveira Yrna Lorena Matos de Oliveira Ana Mércia Dias Nascimento Roseli La Corte

Intestinal parasites cause a significant public health problem worldwide due to the associated morbidities, mainly in infected school-aged children (SAC). The strategy of large-scale deworming in SAC to control the transmission of soil-transmitted helminths (STH) has been advocated by the World Health Organization and was recently adopted in Brazil; however, the long-term effects of mass deworming on the larger parasitological profile have been less studied. After a five-year period of school-based large-scale treatment for STH using an annual single dose of albendazole in a community of Sergipe state, Brazil, a marked reduction in prevalence was observed (15.4%% vs.7.4% for Ascaris sp., 6.0%% vs. 0.4% for hookworm, and 12.8%% vs. 4.5%% for Trichuris trichiura), with the exception of Strongyloides stercoralis, which had no statistically significant change in prevalence. There was, however, an increase in the prevalence of intestinal protozoans, specifically Entamoeba histolytica/E. dispar (0.0%% vs. 36.0%), Blastocystis hominis (0.0%% vs. 40.1%), and Giardia duodenalis (5.6%% vs. 14.5%). Although the findings showed a dramatic reduction in the prevalence of STH after four rounds of preventive chemotherapy, there was an increase in intestinal protozoan infections, indicating a change in the epidemiological profile.

Trichuris trichiura

Strongyloides stercoralis

Deworming

Albendazole

Strongyloidiasis

10.1016/j.actatropica.2019.105279

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Citations (14)