Dalal H. Aljabryn

Princess Nourah bint Abdulrahman University

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Nora A. AlFaris

Princess Nourah bint Abdulrahman University

Jozaa Z. AlTamimi

Princess Nourah bint Abdulrahman University

Mohammed Abdo Yahya

King Saud University

Ghedeir M. Alshammari

King Saud University

Reham I. Alagal

Princess Nourah bint Abdulrahman University

Hussain Aldera

King Saud bin Abdulaziz University for Health Sciences

Mahmoud A. Alkhateeb

Qatar University

Lujain A. AlMousa

Princess Nourah bint Abdulrahman University

Amal Nassir ALKURAIEEF

Princess Nourah bint Abdulrahman University

Nora M. AlKehayez

Princess Nourah bint Abdulrahman University

Cooperative Institutions

Princess Nourah bint Abdulrahman University

Taif University

King Saud University

King Abdullah International Medical Research Center

King Saud bin Abdulaziz University for Health Sciences

King Abdulaziz University

National Guard Health Affairs

King Saud Medical City

Ain Shams University

King Khalid University

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Ellagic acid protects against diabetic nephropathy in rats by regulating the transcription and activity of Nrf2

Journal of Functional Foods (2021)

Jozaa Z. AlTamimi Nora A. AlFaris Ghedeir M. Alshammari Reham I. Alagal Dalal H. Aljabryn

This study examined if the protective effect of Ellagic acid (EA) against streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats involves activation of Nrf2. Diabetes mellitus was induced by a single i.p dose of STZ (65 mg/kg). The Rats were divided into 5 groups (n = 12/each) and treated for 8 weeks as control, control + EA (100 mg/kg), STZ, STZ + EA (100 mg/kg), and STZ + EA + trigonelline (Nrf2 inhibitor/0.2 mg/kg). EA prevented renal damage, oxidative stress, inflammation, and apoptosis. These effects were associated with reduced activity of NF-κB, upregulated GSH, γ-GCL, and SOD, and increased the nuclear translocation of Nrf2. Besides, EA suppressed the cytoplasmic expression of keap1 and its interaction with Nrf2, increased the phosphorylation of Akt and GS3Kβ, and reduced the phosphorylation and nuclear accumulation of Fyn. All these alterations were abolished by trigonelline. In conclusion, EA ameliorates DN in rats by antioxidant and anti-inflammatory potentials.

Ellagic Acid

KEAP1

Trigonelline

10.1016/j.jff.2021.104397

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Citations (25)

The protective effect of shrimp cooked in different methods on high-cholesterol- induced fatty liver in rats

Saudi Journal of Biological Sciences (2020)

Nora A. AlFaris Ghedeir M. Alshammari Jozaa Z. AlTamimi Lujain A. AlMousa Nora M. AlKehayez

This study examined the impact of different cooking methods on fatty acid (FAs) composition of shrimp meat and the ability of these foods to protect against high cholesterol (HC) diet-induced non-alcoholic fatty liver disease (NAFLD) in rats. Shrimp were cooked for 10 min boiled, grilled, or fried in sunflower oil. Rats (n = 6/group) were fed a normal diet (ND)or high-cholesterol diet (HC) each containing boiled, grilled or fried shrimp powder (15% w/w) (NDBS, NDFS, NDGS for ND or HCBS, HCFS, HCDGS for HC diet). Frying alone significantly reduced total levels of saturated FAs (SFA) and increased total mono- and polyunsaturated FAs (MSFA, and PUFAs, respectively) in shrimp meat. It also increased levels of n-6 PUFAs and linoleic acid (LA) and decreased levels of n-3 PUFAs including eicosapentaenoic FAs (EPA) and docosahexaenoic fatty acid (DHA). When fed to HC rats, only diets containing the grilled and boiled shrimp powders significantly prevented the weight loss, lowered fasting and glucose levels, improved glucose and insulin tolerance, and prevented the increase in serum liver markers, ALT and AST. They also reduced hepatic fat accumulation, reduced serum levels and hepatic levels of cholesterol and triglycerides (TGs), reduced hepatic levels of MDA, tumor necrosis factor-alpha (TNF-α), and IL-6, and increased those of glutathione (GSH) and superoxide dismutase (SOD). No alterations in all these parameters were observed in HC-fed rats which fed fried shrimp. In conclusion, boiling and grilling but not frying are the best method to cook shrimp to preserve their fatty acid content and its nutritional value in ameliorating NAFLD.

alpha-Linolenic acid

10.1016/j.sjbs.2020.09.036

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Esculeoside A Decreases Diabetic Cardiomyopathy in Streptozotocin-Treated Rats by Attenuating Oxidative Stress, Inflammation, Fibrosis, and Apoptosis: Impressive Role of Nrf2

Medicina (2023)

Jozaa Z. AlTamimi Nora A. AlFaris Ghedeir M. Alshammari Reham I. Alagal Dalal H. Aljabryn

Background and Objectives: This experiment evaluated the preventative influence of the tomato-derived Esculeoside A (ESA) on diabetic cardiomyopathy in type 1 diabetes mellitus (T1DM) in rats induced by streptozotocin (STZ). It also examined whether the activation of Nrf2 signaling affords this protection. Materials and Methods: Adult male Wistar control nondiabetic rats and rats with T1DM (STZ-T1DM) were given either carboxymethylcellulose as a vehicle or ESA (100 mg/kg) (eight rats/group) orally daily for 12 weeks. A group of STZ-T1DM rats was also treated with 100 mg/kg ESA and co-treated i.p. with 2 mg/kg (twice/week), brusatol, and Nrf2 inhibitors for 12 weeks. Results and Conclusions: Treatment with ESA prevented the gain in heart weight and cardiomyocyte hypertrophy and improved the left ventricular (LV) systolic and diastolic function (LV) in the STZ-T1DM rat group. Likewise, it reduced their serum levels of triglycerides, cholesterol, and low-density lipoproteins (LDL-c), as well as their LV mRNA, cytoplasmic total, and nuclear total levels of NF-κB. ESA also reduced the total levels of malondialdehyde, tumor necrosis factor-α, interleukine-6 (IL-6), Bax, cytochrome-c, and caspase-3 in the LV of the STZ-T1DM rats. In parallel, ESA enhanced the nuclear and cytoplasmic levels of Nrf2 and the levels of superoxide dismutase, glutathione, and heme oxygenase-1, but decreased the mRNA and cytoplasmic levels of keap-1 in the LVs of the STZ-T1DM rats. Interestingly, ESA did not affect the fasting insulin and glucose levels of the diabetic rats. All of these beneficially protective effects of ESA were not seen in the ESA-treated rats that received brusatol. In conclusion, ESA represses diabetic cardiomyopathy in STZ-diabetic hearts by activating the Nrf2/antioxidant/NF-κB axis.

Diabetic Cardiomyopathy

Malondialdehyde

10.3390/medicina59101830

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Total phenolic content in ripe date fruits (Phoenix dactylifera L.): A systematic review and meta-analysis

Saudi Journal of Biological Sciences (2021)

Nora A. AlFaris Jozaa Z. AlTamimi Fatima Ali AlGhamdi Najla A. Albaridi Riyadh A. Alzaheb

Ripe date fruits contain phenolic compounds which possess a high antioxidant activity. The current review was carried out to evaluate total phenolic content in ripe date fruits. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was followed during the review process. Relevant studies published from inception up to March 2019 were retrieved from three databases. Study selection was performed based on specific inclusion criteria. A total of twenty-two articles were selected and included in the present review. Data collected from these studies were organized, pooled, and analyzed using descriptive statistics. Total phenolic content means and medians have been reported for the collected ripe date fruit samples for each included study and pooled data. The results suggested that ripe date fruits contain a potent total phenolic content that can contribute mainly to their antioxidant properties.

Phoenix dactylifera

10.1016/j.sjbs.2021.03.033

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Protective effect of eriodictyol against hyperglycemia-induced diabetic nephropathy in rats entails antioxidant and anti-inflammatory effects mediated by activating Nrf2

Saudi Pharmaceutical Journal (2023)

Jozaa Z. AlTamimi Nora A. AlFaris Ghedeir M. Alshammari Reham I. Alagal Dalal H. Aljabryn

Eriodictyol

10.1016/j.jsps.2023.101817

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Effect of gamma irradiation and calcium carbonate on the overall quality of pumpkin jam during storage

Food Science and Technology (2022)

Amani H. Aljahani Amal Nassir ALKURAIEEF Dalal H. Aljabryn

This study was to investigate the effects of combination of calcium carbonate with irradiation technique on quality characteristics, nutritional values, bioactive components, microbiological loading, and sensory evaluation of pumpkin jam during storage period for 12 months. Pumpkin jam samples were treated with calcium carbonate 1% (CCS), irradiation (2 kGy) and the combination of CCS + 2 kGy. The results indicated that the CCS + 2 kGy treatment significantly helped in retaining ascorbic acid content, which established a little decrease. CCS and CCS + 2 kGy treatments reported similar values for carotenoid contents. Whereas, CCS + 2 kGy treatment showed the highest total flavonoid content. The application of CCS + 2 kGy treatment also reduced the microbial growth for total aerobic plate, yeast and mold counts. The degree of color was higher recorded for CCS treatment, while CCS + 2 kGy treatment gained the highest scores for texture, flavor, taste, and overall acceptability at the end of the storage period. Overall the results pertained that the use of Gamma irradiation combined with calcium carbonate prolonged the shelf life of the pumpkin jam by reduced the microbial load, maintained the quality characterizes, nutritional values, bioactive components, and consumer acceptability of pumpkin jam during storage.

Gamma Irradiation

10.1590/fst.94722

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Evaluating the effects of different processing methods on the nutritional composition of shrimp and the antioxidant activity of shrimp powder

Saudi Journal of Biological Sciences (2021)

Nora A. AlFaris Ghedeir M. Alshammari Jozaa Z. AlTamimi Lujain A. AlMousa Reham I. Alagal

Shrimp is a prevalent food in the Arabian Gulf that is known for its good sensory properties and high nutritional value. The aim of the present work was to assess the effects of diverse processing methods on the nutritional composition of shrimp and the antioxidant activity of shrimp powder. Shrimp (Penaeus semisulcatus) flesh was treated using four processes (salting, frying, grilling, and boiling), following which its macronutrient content, fatty acid profile, vitamins and mineral contents were measured. Also, the antioxidant activity of all shrimp powder extracts was assessed using the 2, 2 diphenyl 1 picrylhydrazyl (DPPH), linoleic acid oxidation inhibition, and reducing power methods. The results revealed that the fresh and processed shrimp flesh had significant nutritional value and the fresh and treated shrimp powders have high antioxidant activity, but the cooking processes have significant effects on the nutritional value and antioxidant activity of shrimp flesh. These effects were greater significantly in grilled shrimp followed by boiled shrimp and then fried shrimp. It is concluded that the high nutritional value and antioxidant activity of shrimp flesh make it an important food for nutritional health promotion for the community.

Flesh

Penaeus

10.1016/j.sjbs.2021.09.029

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Citations (29)

Heavy metals in some commercially fishery products marketed in Saudi Arabia

Food Science and Technology (2022)

Dalal H. Aljabryn

Seven major commercially important marine fisheries species, Fenneropenaeus indicus, Chaceon quinquedens, Lethrinus nebulosus, Scomberomorus commerson, Plectropomus pessuliferus, Pampus argenteus, and Epinephelus summana were seasonally sampled from Jeddah main local fisheries market, Saudi Arabia. The heavy metals, namely arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), iron (Fe), lead (Pb), nickel (Ni), and zinc (Zn) were assessed. Except for arsenic, the results indicated that the levels of tested heavy elements were within the standard limits. The levels of arsenic were high in F. indicus, C. quinquedens, L. nebulosus, P. pessuliferus and E. summana. In addition, Pb showed higher mean levels of 0.89 ± 0.14 mg/kg and 5.05 ± 0.86 mg/kg in S. commerson and P. pessuliferus, respectively, compared to the permissible standard limits. Cd was not found in most samples, except for F. indicus and C. quinquedens where its detected levels exceeded the acceptable standards. Our results may prove the significant roles of seasonal impacts and species variations in the acquisition mechanisms of heavy metals in marine environments. Therefore, the application of a detection program for cumulative residual levels of heavy metals in marine fisheries products is recommended before marketing to ensure the safety of these products.

Epinephelus

10.1590/fst.34222

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Esculeoside A alleviates reproductive toxicity in streptozotocin-diabetic rats’ s model by activating Nrf2 signaling

Saudi Journal of Biological Sciences (2023)

Jozaa Z. AlTamimi Nora A. AlFaris Ghedeir M. Alshammari Reham I. Alagal Dalal H. Aljabryn

This examination studied if Esculeoside A (ESA) alleviates reproductive toxicity in a type 1 diabetes mellitus (T1DM) rat model and if activating Nrf2 underlies this protection. T1DM was established by a single injection of STZ. Aged-matched adult control and STZ-DM rats were administered either the vehicle (5% carboxymethyl cellulose) or ESA (100 mg/kg). An additional group [STZ-DM + ESA (100 mg) + brusatol (2m/kg] was added. All treatments were conducted for 16 weeks. ESA failed to attenuate weight loss, hyperglycemia, and hypoinsulinemia but significantly attenuated the associated dyslipidemia in STZ-DM rats. In parallel, ESA also enhanced total sperm count, motility, survival, reduced head and tail sperm abnormalities, increased circulatory concentrations of follicular stimulating hormone (FSH), testosterone, and Luteinizing hormone (LH), and stimulated the testicular expression of several steroidogenic enzymes (StAR, CYP11A1, CYP17A1, 3β-HSD1) in STZ-DM rats. These observations were associated with a higher testicular increase in the transcription, protein levels, and nuclear activities of Nrf2 that coincided with a reduction in the total levels of MDA and keap1 and a significant increase in the total levels of some antioxidants such as HO-1, SOD, and GSH. In concomitance, ESA reduced the testicular mRNA and nuclear concentrations of NF-κB and depressed the levels of TNF-α and IL-6. Brusatol prevented all these protective effects of ESA. In conclusion, activation of Nrf2 triggers the protective potential of ESA against reproductive toxicity in STZ-DM rats.

Reproductive toxicity

10.1016/j.sjbs.2023.103780

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Citations (7)

Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2

Saudi Journal of Biological Sciences (2021)

Jozaa Z. AlTamimi Nora A. AlFaris Dalal H. Aljabryn Reham I. Alagal Ghedeir M. Alshammari

Diabetes mellitus induces testicular damage, increases sperm abnormalities, and impairs reproductive dysfunction due to induction of endocrine disturbance and testicular oxidative stress. This study evaluated the reproductive protective effect of ellagic acid (EA) against testicular damage and abnormalities in sperm parameters in Streptozotocin (STZ)-induced diabetic rats (T1DM) and examined some possible mechanisms of protection. Adult male rats were segregated into 5 groups (n = 12 rat/each) as control, control + EA (50 mg/kg/day), T1DM, T1DM + EA, and T1DM + EA + brusatol (an Nrf-2 inhibitor) (2 mg/twice/week). All treatments were conducted for 12 weeks, daily. EA preserved the structure of the seminiferous tubules, prevented the reduction in sperm count, motility, and viability, reduced sperm abnormalities, and downregulated testicular levels of cleaved caspase-3 and Bax in diabetic rats. In the control and diabetic rats, EA significantly increased the circulatory levels of testosterone, reduced serum levels of FSH and LH, and upregulated Bcl-2 and all steroidogenic genes (StAr, 3β-HSD1, and 11β-HSD1). Besides, it reduced levels of ROS and MDA but increased levels of GSH and MnSOD and the transactivation of Nrf2. All these biochemical alterations induced by EA were associated with increased activity and nuclear accumulation of Nrf2. However, all these effects afforded by EA were weakened in the presence of brusatol. In conclusion, EA could be an effective therapy to alleviated DM-induced reproductive toxicity and dysfunction in rats by a potent antioxidant potential mediated by the upregulation of Nrf2.

Ellagic Acid

10.1016/j.sjbs.2021.04.005

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Citations (17)