Keshav Raj Paudel

Centenary Institute

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Philip M. Hansbro

Hunter Medical Research Institute

133

Kamal Dua

University of Technology Sydney

128

Dinesh Kumar Chellappan

International Medical University

Sachin Kumar Singh

Lovely Professional University

Gaurav Gupta

Ajman University

Brian G. Oliver

University of Technology Sydney

Gabriele De Rubis

University of Technology Sydney

Nisha Panth

University of Technology Sydney

Meenu Mehta

University of Technology Sydney

Hari Prasad Devkota

Kumamoto University

Cooperative Institutions

University of Technology Sydney

Lovely Professional University

International Medical University

Chitkara University

Mokpo National University

Centenary Institute

University of Sydney

Hunter Medical Research Institute

Uttaranchal University

Delhi Pharmaceutical Science and Research University

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Applications of Extracellular Vesicles as A Drug-Delivery System for Chronic Respiratory Diseases

Nanomedicine (2022)

Bikash Manandhar Keshav Raj Paudel Nisha Panth Philip M. Hansbro Brian G. Oliver

Research centre

10.2217/nnm-2021-0384

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Citations (10)

Epigenetic Therapy as a Potential Approach for Targeting Oxidative Stress–Induced Non-small-Cell Lung Cancer

Ridhima Wadhwa Keshav Raj Paudel Shakti D. Shukla Madhur D. Shastri Gaurav Gupta

Epigenetic Therapy

Vorinostat

10.1007/978-981-15-9411-3_106

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Citations (1)

Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet‐Fed Rats

Evidence-based Complementary and Alternative Medicine (2016)

Hyun-Ho Lee Keshav Raj Paudel Ji‐Eun Jeong An-Jin Wi Whoa-Shig Park

Hypercholesterolemia is a well‐known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. Camellia japonica is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study was carried out to evaluate the effect of C. japonica fruit extracts (CJF) in a high fat diet‐ (HFD‐) induced hypercholesterolemic rat model. CJF was administered orally at three different doses: 100, 400, and 800 mg·kg −1 ·day −1 (CJF 100, 400, and 800, resp.). Our results showed that CJF possessed strong cholesterol‐lowering potency as indicated by the decrease in serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein (LDL), accompanied by an increase in serum high‐density lipoprotein (HDL). Furthermore, CJF reduced serum lipid peroxidation by suppressing the formation of thiobarbituric acid reactive substance. In addition, oil red O (ORO) staining of rat arteries showed decreased lipid‐positive staining in the CJF‐treated groups compared to the control HFD group. Taken together, these results suggest that CJF could be a potent herbal therapeutic option and source of a functional food for the prevention and treatment of atherosclerosis and other diseases associated with hypercholesterolemia.

Thiobarbituric acid

Camellia

Oil Red O

TBARS

High-density lipoprotein

10.1155/2016/9679867

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Citations (27)

Phytochemical profile and biological activity of Juglans regia

结合医学学报：英文版 (2016)

Nisha Nisha Panth Keshav Keshav Raj Keshav Raj Paudel

Phytochemical

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Citations (49)

Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles

Pathology - Research and Practice (2023)

Gabriele De Rubis Keshav Raj Paudel Venkata Sita Rama Raju Allam Vamshikrishna Malyla Vetriselvan Subramaniyan

Nanocarriers

Osteopontin

10.1016/j.prp.2023.154971

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Citations (11)

Eriobotrya japonica extract attenuates the airway inflammation in ovalbumin-induced murine model of asthma

한국자원식물학회 학술심포지엄 (2016)

Keshav Raj Paudel Dong-Wook Kim

In this study, we evaluate the anti-inflammatory activity of Eriobotrya japonica(EJ) leaves extract in ovalbumin (OVA)-induced murine asthma model, human tracheal smooth muscle cell (HTSMC) and RAW264.7 cell. Mice were wensitized by intra peritoneal OVA and challenged with nebulized OVA. EJ was administered orally at various doses. Broncho alveolar labage fluid (BALF) was collected 24 h after the final OVA challenge. Quantification of nitric oxide (NO) and eosinophil peroxidase (EPO) assay in BALF was done by colorimetric assay. Levels of interleukin (IL)-4 and IL-13 in BALF and stained with hematoxylin and eosin for assessment of cell infiltration sections were stained with hematoxylin and eosin for assessment of cell infiltration whereas mucus production and goblet cell hyperplasia was studied by periodic acid schiff staining. For in vitro experiment, western blot was done to analyze pERK1/2 expression and NFkB translocation in HTSMC whereas iNOS and COX-2 expression in RAW264.7 cell. EJ, significantly reduced the levels of BALF`s NO, EPO, MMPs, IL-4, IL-13, and serum IgE. It also decreases inflammatory cell infiltration and mucus production. EJ also attenuated the proliferation of HTSMC and inhibits overexpression of ERK 1/2 and NFkB translocation in HTSMC as well as iNOS, COX-2 expression in RAW 264.7 cell. Our results suggest that, EJ possess protective effect against allergic airway inflammation.

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Exploring the anti-inflammatory and anti-fibrotic activity of NFκB decoy oligodeoxynucleotide-loaded spermine-functionalized acetalated nanoparticles

Chemico-Biological Interactions (2024)

Gabriele De Rubis Amlan Chakraborty Keshav Raj Paudel Chao Wang Vinod K. Kannaujiya

Chronic inflammation, oxidative stress, and airway remodelling represent the principal pathophysiological features of chronic respiratory disorders. Inflammation stimuli like lipopolysaccharide (LPS) activate macrophages and dendritic cells, with concomitant M1 polarization and release of pro-inflammatory cytokines. Chronic inflammation and oxidative stress lead to airway remodelling causing irreversible functional and structural alterations of the lungs. Airway remodelling is multifactorial, however, the hormone transforming growth factor-β (TGF-β) is one of the main contributors to fibrotic changes. The signalling pathways mediating inflammation and remodelling rely both on the transcription factor nuclear factor-κB (NFκB), underlying the potential of NFκB inhibition as a therapeutic strategy for chronic respiratory disorders. In this study, we encapsulated an NFκB-inhibiting decoy oligodeoxynucleotide (ODN) in spermine-functionalized acetalated dextran (SpAcDex) nanoparticles and tested the in vitro anti-inflammatory and anti-remodelling activity of this formulation. We show that NF-κB ODN nanoparticles counteract inflammation by reversing LPS-induced expression of the activation marker CD40 in myeloid cells and counteracts remodelling features by reversing the TGF-β-induced expression of collagen I and α-smooth muscle actin in human dermal fibroblast. In summary, our study highlights the great potential of inhibiting NFκB via decoy ODN as a therapeutic strategy tackling multiple pathophysiological features underlying chronic respiratory conditions.

HMGB1

Decoy

10.1016/j.cbi.2024.111059

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Citations (2)

Nutraceuticals: unlocking newer paradigms in the mitigation of inflammatory lung diseases

Critical Reviews in Food Science and Nutrition (2021)

Yinghan Chan Venkata Sita Rama Raju Allam Keshav Raj Paudel Sachin Kumar Singh Monica Gulati

Persistent respiratory tract inflammation contributes to the pathogenesis of various chronic respiratory diseases, such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. These inflammatory respiratory diseases have been a major public health concern as they are the leading causes of worldwide mortality and morbidity, resulting in heavy burden on socioeconomic growth throughout these years. Although various therapeutic agents are currently available, the clinical applications of these agents are found to be futile due to their adverse effects, and most patients remained poorly controlled with a low quality of life. These drawbacks have necessitated the development of novel, alternative therapeutic agents that can effectively improve therapeutic outcomes. Recently, nutraceuticals such as probiotics, vitamins, and phytochemicals have gained increasing attention due to their nutritional properties and therapeutic potential in modulating the pathological mechanisms underlying inflammatory respiratory diseases, which could ultimately result in improved disease control and overall health outcomes. As such, nutraceuticals have been held in high regard as the possible alternatives to address the limitations of conventional therapeutics, where intensive research are being performed to identify novel nutraceuticals that can positively impact various inflammatory respiratory diseases. This review provides an insight into the utilization of nutraceuticals with respect to their molecular mechanisms targeting multiple signaling pathways involved in the pathogenesis of inflammatory respiratory diseases.

Nutraceutical

10.1080/10408398.2021.1986467

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Citations (28)

Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation

Environmental Science and Pollution Research (2022)

Thiviya Darmarajan Keshav Raj Paudel Mayuren Candasamy Jestin Chellian Thiagarajan Madheswaran

Coronavirus

10.1007/s11356-022-20984-7

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Citations (15)

Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems

Pharmaceutics (2022)

Mohammad Imran Saurav Kumar Jha Nazeer Hasan Areeba Insaf Jitendra Shrestha

Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections. Therefore, to overcome such complications, novel drug delivery systems have gained pharmaceutical scientists’ interest. Significant findings have validated the effectiveness of novel drug delivery systems such as polymeric nanoparticles, liposomes, metallic nanoparticles, dendrimers, and lipid-based nanoparticles against severe microbial infections and combating antimicrobial resistance. This review article comprises the specific mechanism of antibiotic resistance development in bacteria. In addition, the manuscript incorporated the advanced nanotechnological approaches with their mechanisms, including interaction with the bacterial cell wall, inhibition of biofilm formations, activation of innate and adaptive host immune response, generation of reactive oxygen species, and induction of intracellular effect to fight against antibiotic resistance. A section of this article demonstrated the findings related to the development of delivery systems. Lastly, the role of microfluidics in fighting antimicrobial resistance has been discussed. Overall, this review article is an amalgamation of various strategies to study the role of novel approaches and their mechanism to fight against the resistance developed to the antimicrobial therapies.

Anti-Infective Agents

10.3390/pharmaceutics14030586

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Citations (38)