Jonson Yee

Memorial Medical Center

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Kiran Dhanireddy

Tampa General Hospital

Rachel Hogen

Tampa General Hospital

Aaron Strumwasser

LAC+USC Medical Center

Subarna Biswas

University of Southern California

Joseph DiNorcia

Mount Sinai Hospital

Damon Clark

University of Southern California

J. Perren Cobb

Keck Hospital of USC

Hongyi Cui

University of Massachusetts Chan Medical School

Dorothy Liu

Austin Health

Edward Kim

University of Pennsylvania

Cooperative Institutions

University of Southern California

Los Angeles Medical Center

Keck Hospital of USC

LAC+USC Medical Center

Memorial Medical Center

UMass Memorial Medical Center

Southern California University for Professional Studies

University of Massachusetts Chan Medical School

Uniformed Services University of the Health Sciences

UCLA Medical Center

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Pre-Emptive Factor VII Reduces Transfusion Requirements During Orthotopic Liver Transplantation for Patients with Model for End Stage Liver Disease ≥40

Journal of the American College of Surgeons (2017)

Rachel Hogen Joseph DiNorcia Brian T. Nguyen Jonson Yee Damon Clark

Orthotopic liver transplantation

Liver disease

10.1016/j.jamcollsurg.2017.07.466

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Citations (0)

581: PULSE WAVEFORM ANALYSIS VERSUS PULMONARY ARTERY CATHETERIZATION IN ORTHOTOPIC LIVER TRANSPLANTATION

Critical Care Medicine (2016)

Jonson Yee Aaron Strumwasser Rachel Hogen Kiran Dhanireddy Subarna Biswas

Yee, Jonson; Strumwasser, Aaron; Hogen, Rachel; Dhanireddy, Kiran; Biswas, Subarna; Perren Cobb, J.; Clark, Damon

Orthotopic liver transplantation

Cardiac catheterization

10.1097/01.ccm.0000509259.17723.35

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Emergent laparoscopic surgical intervention for perforated hemorrhagic cholecystitis with hemodynamic instability.

PubMed (2022)

Alexander S. Baier Dorothy Liu Jonson Yee Nicole Cherng Hongyi Cui

Hemorrhagic cholecystitis is a rare diagnosis that closely mimics acute cholecystitis. Physical examination, laboratory studies and, in particular, computed tomography imaging allow for rapid diagnosis, stabilization and emergent surgical intervention. We describe our experience with three patients requiring emergent surgical intervention for hemorrhagic cholecystitis with unique clinical features including decreased platelet function due to liver cirrhosis, dual antiplatelet therapy and intraoperative finding of cholecystohepatic communication. Furthermore, we provide video recordings of two cases highlighting the severity of the disease. All presented patients were hemodynamically unstable and showed peritoneal signs on exam. Laboratory studies revealed moderate anemia and leukocytosis, while computed tomography suggested hemorrhage in the gallbladder. All patients required blood transfusions during their care and underwent laparoscopic cholecystectomy. Hemoperitoneum and gallbladder perforation were confirmed intraoperatively. Patients fully recovered without significant postoperative complications due to expedited operative management.

Hemoperitoneum

Leukocytosis

10.1093/jscr/rjac454

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Citations (1)

634: BALANCED BLOOD PRODUCT USE IMPROVES OUTCOMES DURING ORTHOTOPIC LIVER TRANSPLANTATION

Critical Care Medicine (2016)

Rachel Hogen Kiran Dhanireddy Damon Clark Subarna Biswas Joseph DiNorcia

Hogen, Rachel; Dhanireddy, Kiran; Clark, Damon; Biswas, Subarna; Dinorcia, Joseph; Yee, Jonson; Perren Cobb, J.; Strumwasser, Aaron

CobB

Blood product

Orthotopic liver transplantation

10.1097/01.ccm.0000509311.26614.36

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Balanced blood product transfusion during liver transplantation

Clinical Transplantation (2018)

Rachel Hogen Kiran Dhanireddy Damon Clark Subarna Biswas Joseph DiNorcia

This study was conducted to determine whether an intra-operative ratio of at least 1:1:2 of fresh frozen plasma (FFP):platelets (PLTs):packed red blood cells (pRBCs) improves outcomes in orthotopic liver transplantation (OLT).A single-center, retrospective study of deceased donor OLT recipients (MELD ≥15) requiring intra-operative pRBC transfusion (years 2013-2016). Patients were grouped into those receiving an intra-operative ratio of ≥1:1:2 of FFP:PLTs:pRBCs vs ratios <1:1:2.Patients in ≥1:1:2 group (n = 150) and patients in <1:1:2 group (n = 80) were matched for baseline characteristics (P > .05). Patients in the ≥1:1:2 group had lower pRBC and intra-operative blood product requirements (11 ± 0.5 vs 19 ± 1.4 units, P < .001, and 33 ± 1.3 vs 43 ± 3.3 units, P = .006, respectively), improved 1-month mortality (0 vs 8%, P = .002), improved 1-year survival (P = .004), less intra-operative cardiac arrest (3% vs 10%, P = .03), and shorter operating room time (389 ± 7.2 vs 431 ± 17.2 minutes, P = .03). After multivariate adjustment for baseline and intra-operative variables, balanced blood product transfusion (BBPT) was significantly associated with less intra-operative pRBC transfusion (95% confidence interval: 0.60-0.72).Balanced blood product transfusion is associated with reduced transfusion requirements in OLT.

Blood product

Fresh frozen plasma

10.1111/ctr.13191

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Citations (9)