Ilhuicamina Daniel Limón

Benemérita Universidad Autónoma de Puebla

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Jorge Guevara

Universidad Nacional Autónoma de México

Liliana Mendieta

Centro de Investigación Biomédica en Red

Aleidy Patricio-Martínez

Benemérita Universidad Autónoma de Puebla

Alfonso Díaz

Benemérita Universidad Autónoma de Puebla

Edgar Zenteno

Universidad Nacional Autónoma de México

Felipe Patricio

Benemérita Universidad Autónoma de Puebla

José Aguilera

Hospital Universitario Araba

Blanca Espinosa

Instituto Nacional de Enfermedades Respiratorias

Victorino Alatriste

Benemérita Universidad Autónoma de Puebla

Félix Luna

Benemérita Universidad Autónoma de Puebla

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Benemérita Universidad Autónoma de Puebla

118

Universidad Nacional Autónoma de México

Instituto Politécnico Nacional

Center for Research and Advanced Studies of the National Polytechnic Institute

Instituto Nacional de Neurología y Neurocirugía

Universitat Autònoma de Barcelona

Centre National de la Recherche Scientifique

Biomedical Research Networking Center on Neurodegenerative Diseases

Universidad de Puebla

Universidad Autónoma de la Ciudad de México

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Aminoguanidine treatment ameliorates inflammatory responses and memory impairment induced by amyloid-beta 25–35 injection in rats

Neuropeptides (2014)

Alfonso Díaz Karla Rojas Blanca Espinosa Raúl Chávez Edgar Zenteno

Amyloid beta

Gliosis

10.1016/j.npep.2014.03.002

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Citations (53)

Determinación del efecto analgésico del extracto hexánico de flores de Eupatorium arsenei en un modelo de dolor agudo en rata Determination of the analgesic eect of the hexane extract ofowers of Eupatorium arsenei in a model of acute pain in rats

Alma Delia Camilo Rojas Julio C. Pardo-Novoa Rosa E. del Río Ilhuicamina Daniel Limón

The aim of this study was to investigate analgesic activity of extract ofowers of Eupatorium arsenei using a thermal model of acute pain. Wistar female rats were administered with 200 mg/kg of extract dissolved in sesame oil intraperitoneally, the control group received vehicle. The analgesic activity was determined using the model of tailick. The group administered with the extract showed analgesic eect 30 minutes after the administration, eect duration was 6 hours. The dierent stage of the estrous cycle does not modify the nociceptive response of animals. The possible interaction between chromene compounds present in the extract with the COX-2, enzyme responsible for the nociceptive process, may be the source of the observed analgesic eect.

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β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease

International Journal of Molecular Sciences (2023)

Roberto A. Galeana-Ascencio Liliana Mendieta Ilhuicamina Daniel Limón Dino Gnecco Joel L. Terán

The β-secretase-1 enzyme (BACE-1) performs a key role in the production of beta-Amyloid protein (Aβ), which is associated with the development of Alzheimer’s disease (AD). The inhibition of BACE-1 has been an important pharmacological strategy in the treatment of this neurodegenerative disease. This study aims to identify new potential candidates for the treatment of Alzheimer’s with the help of in silico studies, such as molecular docking and ADME prediction, from a broad list of candidates provided by the DrugBank database. From this analysis, 1145 drugs capable of interacting with the enzyme with a higher coupling energy than Verubecestat were obtained, subsequently only 83 presented higher coupling energy than EJ7. Applying the oral route of administration as inclusion criteria, only 41 candidates met this requirement; however, 6 of them are associated with diagnostic tests and not treatment, so 33 candidates were obtained. Finally, five candidates were identified as possible BACE-1 inhibitors drugs: Fluphenazine, Naratriptan, Bazedoxifene, Frovatriptan, and Raloxifene. These candidates exhibit pharmacophore-specific features, including the indole or thioindole group, and interactions with key amino acids in BACE-1. Overall, this study provides insights into the potential use of in silico methods for drug repurposing and identification of new candidates for the treatment of Alzheimer’s disease, especially those targeting BACE-1.

10.3390/ijms24098164

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Citations (7)

Novel Pharmacotherapies for L-DOPA-Induced Dyskinesia

Springer eBooks (2021)

Yousef Tizabi Bruk Getachew Robert Copeland Rosario Moratalla Felipe Patricio

Amantadine

Apomorphine

Memantine

10.1007/978-3-030-71519-9_218-1

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Citations (5)

Determinación del efecto analgésico del extracto hexánico de flores de Eupatorium arsenei en un modelo de dolor agudo en rata

Revista mexicana de ciencias farmacéuticas (2015)

Alma Delia Rojas C.Julio C. Pardo-Novoa Rosa Elva del Río T.Mario A. Gómez‐Hurtado Ilhuicamina Daniel Limón

El objetivo del trabajo fue determinar el probable efecto analgesico del extracto de flores de Eupatorium arsenei, empleando un modelo termico de dolor agudo. Ratas hembras Wistar fueron administradas con 200 mg/kg de extracto disuelto en aceite de sesamo por via intraperitoneal, el grupo control recibio vehiculo. La actividad analgesica fue determinada empleando el modelo de sacudida de cola. El grupo administrado con el extracto mostro efecto analgesico 30 minutos despues de la administracion, la duracion del efecto fue de 6 horas. Las diferentes fases del ciclo estral no modificaron la respuesta nociceptiva de los animales. La posible interaccion entre los compuestos tipo cromeno presentes en el extracto con la enzima COX-2, mediadora del proceso nociceptivo, podria ser la responsable del efecto analgesico observado

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Citations (2)

Differential Expression of Striatal ΔFosB mRNA and FosB mRNA After Different Levodopa Treatment Regimens in a Rat Model of Parkinson’s Disease

Neurotoxicity Research (2019)

Victoria Palafox-Sánchez Victoria Sosti Gabriel Ramirez‐Garcia Jaime Kulisevsky José Aguilera

FOSB

10.1007/s12640-018-9993-0

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Citations (6)

El dolor. Una revisión a la evolución del concepto

Ciencia Nicolaita (2016)

Guadalupe García Liliana Mendieta Victorino Alatriste Félix Luna Ilhuicamina Daniel Limón

?Que es el dolor? ?Que lo produce? ?Como se cura? son interrogantes que el hombre se ha planteado desde el inicio de la civilizacion. Las respuestas se han modificado a traves del tiempo. En la antiguedad el dolor fue atribuido a dioses, demonios y espiritus y se creia que podia ser eliminado con hechizos o haciendo perforaciones en el craneo del enfermo. Tambien se penso que lo producian “los espiritus animales” que habitaban en el cuerpo. Despues de un largo camino de observacion y de investigacion, actualmente se sabe que el dolor es una respuesta, resultado de la estimulacion de receptores especiales llamados nociceptores, quetransforman los estimulos dolorosos en senales electricas que viajan por los nervios y llegan al cerebro donde se interpretan y traducen. Ademas, se ha establecido una clasificacion de los diferentes tipos de dolor y se ha evolucionado en las terapias a base de analgesicos para su tratamiento.

10.35830/cn.vi69.339

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Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat

Behavioural Neurology (2022)

Ana Karina Aguilar-Peralta Alejandro Gonzalez-Vazquez Constantino Tomás-Sanchez Víctor Manuel Blanco-Álvarez Daniel Martínez‐Fong

Exercise performance and zinc administration individually yield a protective effect on various neurodegenerative models, including ischemic brain injury. Therefore, this work was aimed at evaluating the combined effect of subacute prophylactic zinc administration and swimming exercise in a transient cerebral ischemia model. The prophylactic zinc administration (2.5 mg/kg of body weight) was provided every 24 h for four days before a 30 min common carotid artery occlusion (CCAO), and 24 h after reperfusion, the rats were subjected to swimming exercise in the Morris Water Maze (MWM). Learning was evaluated daily for five days, and memory on day 12 postreperfusion; anxiety or depression-like behavior was measured by the elevated plus maze and the motor activity by open-field test. Nitrites, lipid peroxidation, and the activity of superoxide dismutase (SOD) and catalase (CAT) were assessed in the temporoparietal cortex and hippocampus. The three nitric oxide (NO) synthase isoforms, chemokines, and their receptor levels were measured by ELISA. Nissl staining evaluated hippocampus cytoarchitecture and Iba-1 immunohistochemistry activated the microglia. Swimming exercise alone could not prevent ischemic damage but, combined with prophylactic zinc administration, reversed the cognitive deficit, decreased NOS and chemokine levels, prevented tissue damage, and increased Iba-1 (+) cell number. These results suggest that the subacute prophylactic zinc administration combined with swimming exercise, but not the individual treatment, prevents the ischemic damage on day 12 postreperfusion in the transient ischemia model.

Nissl body

NeuN

Elevated plus maze

Water maze

10.1155/2022/5388944

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Citations (10)

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

Frontiers in Genetics (2024)

Dulcemaría Gavito-Covarrubias Ivonne Ramírez‐Díaz Josué Guzmán-Linares Ilhuicamina Daniel Limón Dulce María Manuel-Sánchez

Environmental pollution nowadays has not only a direct correlation with human health changes but a direct social impact. Epidemiological studies have evidenced the increased damage to human health on a daily basis because of damage to the ecological niche. Rapid urban growth and industrialized societies importantly compromise air quality, which can be assessed by a notable accumulation of air pollutants in both the gas and the particle phases. Of them, particulate matter (PM) represents a highly complex mixture of organic and inorganic compounds of the most variable size, composition, and origin. PM being one of the most complex environmental pollutants, its accumulation also varies in a temporal and spatial manner, which challenges current analytical techniques used to investigate PM interactions. Nevertheless, the characterization of the chemical composition of PM is a reliable indicator of the composition of the atmosphere, the quality of breathed air in urbanized societies, industrial zones and consequently gives support for pertinent measures to avoid serious health damage. Epigenomic damage is one of the most promising biological mechanisms of air pollution-derived carcinogenesis. Therefore, this review aims to highlight the implication of PM exposure in diverse molecular mechanisms driving human diseases by altered epigenetic regulation. The presented findings in the context of pan-organic cancer, fibrosis, neurodegeneration and metabolic diseases may provide valuable insights into the toxicity effects of PM components at the epigenomic level and may serve as biomarkers of early detection for novel targeted therapies.

Epigenomics

Environmental epidemiology

10.3389/fgene.2023.1306600

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Citations (8)

Ansiedad y depresión en los estudiantes de licenciatura de ciencias naturales y exactas de la BUAP-México

Abdi G. González-Benitez Luis D. Luna-Centeno Victorino Alatriste Alan Carrasco‐Carballo Isabel Martínez

10.11235/buap.05.19.03

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Citations (0)