Peta A. Neale

Griffith University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Beate I. Escher

Helmholtz Centre for Environmental Research

Frédéric D.L. Leusch

Griffith University

Shima Ziajahromi

Griffith University

Anupama Kumar

Commonwealth Scientific and Industrial Research Organisation

Steven D. Melvin

Griffith University

Rita Schlichting

Helmholtz Centre for Environmental Research

Hsuan-Cheng Lu

Griffith University

Martin Krauß

Helmholtz Centre for Environmental Research

A.I. Schäfer

Karlsruhe Institute of Technology

Michael St. J. Warne

University of Queensland

Cooperative Institutions

University of Queensland

Helmholtz Centre for Environmental Research

Griffith University

Swiss Federal Institute of Aquatic Science and Technology

RWTH Aachen University

University of Tübingen

Commonwealth Scientific and Industrial Research Organisation

James Cook University

Environmental Protection Agency

UNSW Sydney

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Solid-phase extraction as sample preparation of water samples for cell-based and otherin vitrobioassays

Environmental Science Processes & Impacts (2018)

Peta A. Neale Werner Brack Sélim Aı̈t-Aı̈ssa Wibke Busch Juliane Hollender

Effect recovery for bioassays was evaluated and was similar to recovery by chemical analysis for the studied SPE methods, providing support of bioassay use for water quality monitoring.

Solid phase extraction

Sample Preparation

10.1039/c7em00555e

Cite

Citations (61)

Bioanalytical Tools in Water Quality Assessment

IWA Publishing eBooks (2021)

Beate I. Escher Peta A. Neale Frédéric D.L. Leusch

The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012. The field has exploded since and the second edition updates and reviews the application of bioanalytical tools for water quality assessment including surveillance monitoring. The book focuses on applications to water quality assessment ranging from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Emerging applications for other environmental matrices are also included. Bioanalytical Tools in Water Quality Assessment, Second Edition, not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. The book can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists and toxicologists. Detailed descriptions of dose-response assessment, data reporting, mixture modelling and quality assurance/quality control are complemented by a series of online resources and tools to apply some of the principles and data methods explained in this book. This supplementary information is available at www.ufz.de/bioanalytical-tools. ISBN: 9781789061970 (Paperback) ISBN: 9781789061987 (eBook)

10.2166/9781789061987

Cite

Citations (92)

Effect‐Based Trigger Values for Mixtures of Chemicals in Surface Water Detected with In Vitro Bioassays

Environmental Toxicology and Chemistry (2020)

Beate I. Escher Peta A. Neale

Abstract Effect‐based trigger (EBT) values for in vitro bioassays are important for surface water quality monitoring because they define the threshold between acceptable and poor water quality. They have been derived for highly specific bioassays, such as hormone‐receptor activation in reporter gene bioassays, by reading across from existing chemical guideline values. This read‐across method is not easily applicable to bioassays indicative of adaptive stress responses, which are triggered by many different chemicals, and activation of nuclear receptors for xenobiotic metabolism, to which many chemicals bind with rather low specificity. We propose an alternative approach to define the EBT from the distribution of specificity ratios of all active chemicals. The specificity ratio is the ratio between the predicted baseline toxicity of a chemical in a given bioassay and its measured specific endpoint. Unlike many previous read‐across methods to derive EBTs, the proposed method accounts for mixture effects and includes all chemicals, not only high‐potency chemicals. The EBTs were derived from a cytotoxicity EBT that was defined as equivalent to 1% of cytotoxicity in a native surface water sample. The cytotoxicity EBT was scaled by the median of the log‐normal distribution of specificity ratios to derive the EBT for effects specific for each bioassay. We illustrate the new approach using the example of the AREc32 assay, indicative of the oxidative stress response, and 2 nuclear receptor assays targeting the peroxisome proliferator–activated receptor gamma and the arylhydrocarbon receptor. The EBTs were less conservative than previously proposed but were able to differentiate untreated and insufficiently treated wastewater from wastewater treatment plant effluent with secondary or tertiary treatment and surface water. Environ Toxicol Chem 2021;40:487–499. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

Xenobiotic

In vitro toxicology

10.1002/etc.4944

Cite

Citations (49)

In vitro bioassays reveal that additives are significant contributors to the toxicity of commercial household pesticides

Aquatic Toxicology (2018)

Jason P. van de Merwe Peta A. Neale Steven D. Melvin Frédéric D.L. Leusch

10.1016/j.aquatox.2018.03.033

Cite

Citations (42)

ECHIDNA (Emerging CHemIcals Database for National Awareness): a framework to prioritise contaminants of emerging concern in water

Journal of Water and Health (2023)

Peta A. Neale Steven D. Melvin Marty Hancock Frédéric D.L. Leusch

Abstract The widespread presence of contaminants of emerging concern (CEC) in surface waters, treated wastewater and drinking water is an ongoing issue for the water industry. The absence of regulatory guidance and limited occurrence, toxicity and removal data are defining criteria of CEC and make it difficult to prioritise which CEC pose the greatest risk. The online Emerging CHemIcals Database for National Awareness (ECHIDNA) aims to classify and prioritise CEC based on their potential risk, with the information presented in an easily accessible and intuitive manner. A candidate list of almost 1,800 potential CEC, including pesticides, pharmaceuticals and industrial compounds, was compiled using both Australian and international resources. These were ranked based on in silico assessment of their persistent, bioaccumulative and toxic (PBT) properties, as well as potential chronic toxicity hazard, yielding 247 CEC for further prioritisation. Risk Quotients (RQ) identified between 5 and 87 CEC posing a risk to human and ecosystem health, respectively, across drinking water, surface water, treated wastewater and raw wastewater. While the ability of the water industry to effectively prioritise CEC is limited by candidate identification and data availability, ECHIDNA can provide valuable information for better decision-making surrounding CEC management.

10.2166/wh.2023.190

Cite

Citations (1)

Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis

Environmental Pollution (2016)

Maria König Beate I. Escher Peta A. Neale Martin Krauß Klára Hilscherová

Xenobiotic

10.1016/j.envpol.2016.11.011

Cite

Citations (204)

Effect-based trigger values for in vitro bioassays: Reading across from existing water quality guideline values

Water Research (2015)