Current research on infrared simulation often focuses mainly on infrared imaging simulation by computer and pays little attention to outdoor simulation of infrared radiation characteristics of targets. In order to simulate infrared radiance of targets outdoors, in this paper we propose a new outdoor simulation method on the basis of heating the cloth by electricity. There are two major contributions in the paper. Firstly, uneven distributing of temperature field of the cloth surface is considered and the long-wave thermal imager is used as a link of the temperature control system. On the basis of many experiments, the expression is concluded about the relation of the temperature obtained by the lone-wave thermal imager and the temperature obtained by the temperature control system and the environmental temperature at the experimental scene. Secondly, the influence of the environment at the experimental scene on the infrared radiance of the cloth surface is thought over. Thanks to two measures above, simulation precision of infrared radiance is made much better. The results of many outdoor experiments demonstrate the performance of the proposed approach.
Abstract Background and Purpose Liver cancer is the fourth leading cause of cancer-related death worldwide, and hepatocellular carcinoma (HCC) is the most common primary liver cancer. APG-1252 is a small molecule inhibitor of Bcl-2/Bcl-xl, and the anti-tumor effect of APG-1252 in HCC, or its anti-tumor effects in combination with cabozantinib, has not been researched. Experimental Approach: TCGA database analysis was used to analysis the gene expression levels of Bcl-2 and Bcl-xl in HCC tissues. Western Blot was used to detect the proteins’ expression level. And the inhibitory effects of APG-1252 and Cabozantinib on the proliferation of HCC cell lines was detected by CCK-8. The effect on the migration and invasion of HCC cells was verified by Transwell assay. Huh7 xenograft model in nude mice was used to detect the combined effect in vivo. Key Results: We found that APG-1252 monotherapy could inhibit the proliferation and migration of HCC cells and promote apoptosis of HCC cells. APG-1252 combined with Cabozantinib could inhibit the proliferation, migration and invasion of HCC cells and promote the apoptosis of hepatocellular carcinoma cells and exerted synergistic effect in vivo. The combination could significantly downregulate MEK/ERK phosphorylation levels. Besides, the treatment of Cabozantinib could cause the protein level of phosphorylation CREB and BCL-XL increased, while combined with APG-1252 could impair this effect. Conclusion and Implications: Our data suggest that APG-1252 in combination with Cabozantinib can provide more effective treatment strategies for HCC patients and deserve further clinical investigation.
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