Abstract The genuine Chinese medicinal (GCM), also known as Dao-di Herbs, is a synonym for high quality Chinese medicinal materials, which has been established in thousands of years of clinical practice and is a comprehensive standard for evaluating the quality of Chinese medicinal materials. The newest data from the Fourth National Survey of Chinese Medicinal Resources showed that Sichuan Province has 7290 types of Chinese medicine and 86 GCM, both ranking highly in China. The characteristics like diverse species, wide distribution, higher yield, and good quality are considered as advantages of geo-herbals grown in Sichuan. Resources guarantee and high-quality development of those medicine materials make a difference in local Chinese medicine quality promotion and Chinese medicine industry and technology development to serve the public's needs, assist targeted poverty alleviation, and strengthen ecological protection. This review aims to outline significant progress in the recent ten years regarding regionalization, germplasm resources, and quality evaluation around the quality assurance of GCM in Sichuan, China.
High-steep gently inclined mining slopes, prevalent globally, often suffer significant deformation, leading to landslides due to numerous goafs. This research investigates the critical role of goaf location in controlling deformation, failure mechanisms, and disaster evolution, vital for safe mining practices. Through field investigations and model generalization in Guizhou, a physical model test method was used to study three positions of goafs: under the shoulder and foot of the slope, under the slope shoulder, and within the slope. Findings highlight the stronger influence of the goaf's mutual position with the slope shoulder on slope and overburden deformation and failure compared to the slope toe. Deformation and failure modes evolve from collapse toppling to collapse slip and collapse settlement as the goaf shifts from the near slope surface to inside of the slope. Statistical analysis of fracture distribution in the goaf's overlying strata reveals damage increase with larger goafs, following a Gaussian distribution, with concentrated damage in the middle. The study identifies the maximum damage area, influenced by the horizontal distance between the goaf center and slope shoulder. These insights advance understanding of overburden rock deformation in gently inclined high-steep mining slopes.
The paper is aimed to study the dynamic accumulation regulation of curcumin (Cur), demethoxycurcumin (DMC) and bisdemethoxyeurcumin (BDMC) in three strains of Curcuma longa, and provide scientific references for formalized cultivation, timely harvesting, quality control and breeding cultivation of C. longa. The accumulation regulation of the three curcumin derivatives was basically the same in rhizome of three strains. The relative contents decreased along with plant development growing, while the accumulation per hectare increased with plant development growing. The accumulation of curcuminoids per hectare could be taken as the assessment standard for the best harvest time of C. longa. A3 was the best strain in terms of Cur and BDMC content.
Abstract Angelica dahurica（Fisch. ex Hoffm.）Benth.et Hook.f.var.formosana（Boiss.）Shan et Yuan (A. dahurica) is a famous traditional Chinese medicine commonly used in clinic, with anti-inflammatory, analgesic, anti-tumor, antibacterial, whitening and other pharmacological effects. However, early bolting of A. dahurica compromises the quality of the roots and hence is a major limitation for yield of medicinal materials. To date, the molecular factors of early bolting occurrenc and its effect on the growth of A. dahurica are unexplored. Hence, we commenced a transcriptome study by using the Illumina NovaSeq 6000 at two developmental types i.e. early-bolting and non-bolting (normal) roots of A. dahurica. Overall, 2,185 up and 1,414 down-regulated genes were obtained. A large number of identified transcripts were related to genes involved in early bolting. Gene ontology analysis highlighted differentially expressed genes that play a key role in various pathways. These pathways were mainly linked to cellular, molecular and biological processes. The morphological characteristics and coumarins content were also changed signifcantly in the early bolting roots of A. dahurica. This study lays a path towards understanding the transcriptomic control of early bolting in A. dahurica, which could be further applied to enhance the medicinal value.
Traditional Chinese medicine(TCM) resources refer to the total reserves of plants, animals, and minerals that can be used as raw materials of TCM(including Chinese medicial materials, TCM decoction pieces, TCM dispensing granules, traditional Chinese patent medicine, and TCM hospital preparation) and folk herbal medicine, which served as the material basis of inheritance, innovation, and development of TCM. In recent years, the sustainable utilization of TCM resources has received high attention and acquired a series of significant achievements in resource survey, quality evaluation, resource protection, innovative technology, and development and utilization, which effectively promoted the sustainable utilization of TCM resources and high-quality development of the TCM industry. The most urgent issue currently is to shift the focus of the research on the sustainable utilization of TCM resources from a sustainable utilization technology system to a sustainable utilization evaluation indicator system. Therefore, in order to objectively evaluate the ability, level, and trend of the sustainable utilization of TCM resources, an evaluation indicator system for sustainable utilization of TCM resources(EIS-TCMRSU) and methods for measuring and determining various standards and indicators were innovatively constructed. With the support of economic policies and scientific regulation of TCM policies, emerging technologies and new tools and methods could be applied to achieve the strategic goals of sustainable utilization and sustainable development of TCM resources. Based on the driving force-pressure-state-impact-response(DPSIR) model, key indicators including resource driving force, environmental pressure, resource state, socio-economic impact, and management response were determined by analyzing the industry chain bottleneck problems and development factors related to the sustainable utilization of TCM resources. According to the scientific, systematic, comparable, dynamic, and operable principles, the EIS-TCMRSU theoretical system was constructed to accurately reflect the ability and development trend of the sustainable utilization of TCM resources and promote the EIS-TCMRSU research from theoretical exploration to practical application. It ensured objective evaluation of the level and ability of sustainable utilization of TCM resources and provided a theoretical basis and practical guidance for the sustainable utilization and sustainable development of TCM resources. In addition, it is of great significance for promoting high-level safety supervision of TCM and high-quality development of the TCM industry.
Guided by the basic theory of traditional Chinese medicine and using modern scientific methods, Dao-di herbs pharmacology studies the nature, performance, interaction with the body and its clinical application.It is a bridge between the basic research and clinical application of Dao-di herbs. It can objectively describe the law of efficacy of Dao-di herbs, scientifically explain the mechanism of efficacy of Dao-di herbs, explore and establish the standards and methods of Dao-di herbs based on biological effect and clinical efficacy, and provide scientific basis for the special properties, pharmacology and clinical value of Dao-di herbs.Furthermore, we put forward a new idea of building the standard of Dao-di herbs based on the curative effect rather than the origin.The Dao-di herbs standard should come from the systematic research of traditional Dao-di herbs producing areas and form a new characteristic system, through the extraction of environmental, genetic, character, chemical, pharmacological and other characteristics.This standard originates from the tradition, but it is higher than the tradition. It may not have the origin meaning of strict administrative division, but it can better reflect the pharmacological characteristics and excellent clinical value of Dao-di herbs.
Based on the systematic summary of the results of the fourth general survey of traditional Chinese medicine resources, the cultivation of large varieties of Chinese material medica and the latest research on health industrial development, the novel concepts and scientific connotations of generalized science of Chinese material medica are put forward, and the basic ideas and methods of a new Chinese medicine academic system, the cultivation system of large varieties of Chinese medicinal materials and the application system of the large health industry are constructed. This kind of generalized science of Chinese material medica, rooted in the traditional Chinese culture and the theory of "preventive treatment of disease", can avoid the narrow prospect induced by the increasing specialization and refinement of knowledge of science of Chinese material medica. It will play an important role in the modernization, industrialization, internationalization of traditional Chinese medicine.
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