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BC

Bea Crain

Yeshiva University

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Stanley M. Crain

Albert Einstein College of Medicine

Edith R. Peterson

Albert Einstein College of Medicine

Eric J. Simon

Boehringer Ingelheim (Germany)

Crain Sm

Albert Einstein College of Medicine

Tara Finnigan

Albert Einstein College of Medicine

Eric Simon

Hochschule Magdeburg-Stendal

Makman Mh

Albert Einstein College of Medicine

Jack M. Hiller

New York University

Peterson Er

Simon Ej

Edinburgh Royal Infirmary

Cooperative Institutions

Albert Einstein College of Medicine

Yeshiva University

New York University

John F. Kennedy Center for the Performing Arts

Columbia University Irving Medical Center

The Bronx Defenders

Columbia University

NYU Langone Health

Rutgers, The State University of New Jersey

Rutgers New Jersey Medical School

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Selective depression by opioid peptides of sensory-evoked dorsal-horn network responses in organized spinal cord cultures

Brain Research (1978)

Stanley M. Crain Bea Crain Edith R. Peterson Eric J. Simon

Dorsal root ganglion

Neurite

GDF7

10.1016/0006-8993(78)91014-4

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Citations (46)

Development of tolerance to opiates and opioid peptides in organotypic cultures of mouse spinal cord

Life Sciences (1979)

Stanley M. Crain Bea Crain Tara Finnigan Eric Simon

Opiate

Drug tolerance

10.1016/0024-3205(79)90426-0

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Citations (33)

Development of cross-tolerance to 5-hydroxytryptamine in organotypic cultures of mouse spinal cord-ganglia during chronic exposure to morphine

Life Sciences (1982)

Stanley M. Crain Bea Crain Edith R. Peterson

Opiate

Methysergide

10.1016/0024-3205(82)90584-7

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Citations (19)

Selective opiate depression of sensory-evoked synaptic networks in dorsal horn regions of spinal cord cultures

Brain Research (1977)

Stanley M. Crain Edith R. Peterson Bea Crain Eric J. Simon

DADLE

Dorsal root ganglion

10.1016/0006-8993(77)90058-0

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Citations (38)

DEVELOPMENT OF TOLERANCE TO OPIATES IN EXPLANTS OF MOUSE SPINAL CORD WITH ATTACHED DORSAL ROOT GANGLIA

Elsevier eBooks (1980)

Stanley M. Crain Bea Crain Tara Finnigan Eric Simon

Dorsal root ganglion

Opiate

10.1016/b978-0-08-025488-3.50137-9

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Citations (0)

Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures

Brain Research (1987)

Stanley M. Crain Bea Crain Maynard H. Makman

Dorsal root ganglion

10.1016/0006-8993(87)90670-6

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Citations (67)

Cyclic AMP or forskolin rapidly attenuates the depressant effects of opioids on sensory-evoked dorsal-horn responses in mouse spinal cord-ganglion explants

Brain Research (1986)

Stanley M. Crain Bea Crain Edith R. Peterson

Dorsal root ganglion

10.1016/0006-8993(86)91105-4

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Citations (41)

Pertussis toxin treatment results in tolerance to the depressant effects of opioid, monoaminergic, and muscarinic agonists on dorsal-horn network responses in mouse spinal cord-ganglion cultures.

Crain Sm Bea Crain Makman Mh

After treatment of mouse spinal cord-ganglion explants with pertussis toxin (PTX), the acute depressant effects of opioids on sensory-evoked dorsal-horn network responses are markedly attenuated, and characteristic cord discharges can then occur even in the presence of greater than 100-fold higher opioid concentrations, as observed after chronic exposure to opioids. The usual acute depressant effects of serotonin, norepinephrine, and oxotremorine on dorsal-horn discharges are similarly attenuated in PTX-treated cultures. These results together with our previous physiologic and biochemical analyses of adenylate cyclase (AC) and cyclic AMP (cAMP) activities in cord-ganglion cultures suggest that the neuromodulatory effects of opioid, monoaminergic and muscarinic agonists on primary afferent networks in the spinal cord may be mediated by binding to neuronal receptor subtypes that are negatively coupled via Gi to a common pool of AC.

Monoaminergic

Oxotremorine

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Citations (2)

Exposure to 4-aminopyridine prevents depressant effects of opiates on sensory-evoked dorsal-horn network responses in spinal cord cultures

Life Sciences (1982)

Stanley M. Crain Bea Crain Edith R. Peterson Jack M. Hiller Eric J. Simon

Opiate

Depressant

10.1016/0024-3205(82)90583-5

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Citations (9)

Selective depression by opiates and opioid peptides of sensory evoked dorsal horn network responses in organized fetal mouse spinal cord cultures.

Crain Sm Bea Crain Peterson Er Simon Ej

Depression

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Citations (2)