Zbigniew Kwias

Poznan University of Medical Sciences

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Piotr Milecki

Greater Poland Cancer Center

Andrzej Antczak

Poznan University of Medical Sciences

Joanna Wesoły

Adam Mickiewicz University in Poznań

Tomasz Stachowski

Poznan University of Medical Sciences

Tomasz Milecki

Poznan University of Medical Sciences

Witold Malendowicz

Poznan University of Medical Sciences

Hans A.R. Bluyssen

Adam Mickiewicz University in Poznań

Piotr Martenka

Greater Poland Cancer Center

G. Stryczyńska

Greater Poland Cancer Center

Katarzyna Kluzek

Adam Mickiewicz University in Poznań

Cooperative Institutions

Poznan University of Medical Sciences

Greater Poland Cancer Center

Centrum Onkologii

Adam Mickiewicz University in Poznań

Pomeranian Medical University

International Hereditary Cancer Center

Heliodor Swiecicki Clinical Hospital

Ministry of Health

Sanjay Gandhi Post Graduate Institute of Medical Sciences

University of Zielona Góra

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Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat

International Journal of Molecular Medicine (2006)

Witold Malendowicz Marcin Ruciński C Macchi Raffaella Spinazzi Agnieszka Ziółkowska

Leptin is an adipose tissue-secreted hormone that acts via specific receptors (Ob-R), of which six isoforms are at present recognized (from Ob-Ra to Ob-Rf). Ob-Rb is the only isoform able to activate JAK-STAT and MAPK signaling cascades. A large body of evidence suggests that leptin and its receptors are involved in prostate physiology and pathophysiology in humans, but studies on the leptin system in the rat prostate are lacking. Reverse transcription-polymerase chain reaction showed the expression of mRNAs of leptin, Ob-Ra, Ob-Rb, Ob-Rc, Ob-Re and Ob-Rf in adult rat seminal vesicles and prostate (coagulating, dorsal, ventral and lateral lobes). Western blotting demonstrated the presence in these specimens of the Ob-Rb protein, and immunocytochemistry revealed that Ob-Rb was mainly located in their epithelial-cell component. Collectively, these findings strongly suggest that leptin and Ob-R may be involved in the autocrine-paracrine functional regulation of the epithelial cells of adult rat seminal vesicles and prostate.

Leptin receptor

10.3892/ijmm.18.4.615

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Citations (29)

[Cardiac arrhythmias during extracorporeal shock wave lithotripsy].

PubMed (1993)

Romuald Ochotny Przemysław Mitkowski W Woźniak Piotr Szymański Andrzej Antczak

Holter monitoring was performed in 55 patients (24 women, 31 men), mean age 50.7 +/- 11.3 who underwent ECG-triggered extracorporeal shock wave lithotripsy (ESWL). Patients were divided into two groups A--30 with history of cardiac disease and B--25 control. The heart rate was significantly higher before and after ESWL in the first group. The number of premature ventricular contractions was higher during ESWL in the same group. No other cardiac complication was observed.

Extracorporeal

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Treatment of bladder cancer: present and perspectives

Contemporary Oncology/Współczesna Onkologia (2003)

Iwona Skoneczna Piotr Milecki Sergiusz Nawrocki Tomasz Skacel Zbigniew Kwias

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[Vesico-uterine fistula].

PubMed (1987)

Zbigniew Kwias J Strzyzowski Witold M. Sokolowski B Dardas R Predki

Vesicovaginal Fistula

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RELATION BETWEEN MUTATIONS IN PROSTATE CANCER AND FAMILIAL HISTORY OF CANCER PREDISPOSING GENES WITH THE AGE OF PROSTATE CANCER PATIENTS AT THE TIME OF DIAGNOSIS - IMPACT ON SCREENING INDICATIONS

The Journal of Urology (2009)

Andrzej Antczak Małgorzata Stawicka Dariusz Iżycki Dariusz Godlewski Cezary Cybulski

Allelic variants of CHEK2 contribute to an elevated risk for human breast cancer and possibly other cancer types. In particular, the CHEK2*1100delC polymorphic variant has been identified as a low-penetrance breast cancer susceptibility allele in breast cancer families with wild type BRCA1 and BRCA2. To better understand the molecular basis by which this allele increases risk for disease, we have generated a mouse in which the wild type CHEK2 (Chk2 in mouse) allele has been replaced with the 1100delC variant. Mouse embryo fibroblasts (MEFs) derived from these mice have an altered cell cycle profile in which a far greater proportion of cells are in S-phase and in G2 (4N) compared with wild type cells. The mutant cells show signs of spontaneous genomic instability as indicated by polyploidy and an increase in DNA double strand breaks.

CHEK2

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10.1016/s0022-5347(09)61843-7

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BASIC SCIENCE Leptin receptor isoforms in benign prostatic hyperplasia (BPH). BPH and prostate cancer – no association between plasma concentrations of leptin and prostate specific antigen (PSA)

Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication (2009)

Witold Malendowicz Zbigniew Kwias

Introduction. Leptin (Ob) is an adipose tissue-secreted hormone. Out of six recognized isoforms of leptin receptor only the long form (Ob-Rb), in humans (huOb-R), activates full biological function of that cytokine. Recently, expression of leptin – leptin receptor system was demonstrated in the rat prostate, while data for human prostate are scarce and conflicting. Therefore present studies aimed to investigate expression of leptin and leptin receptor isoform genes in prostates of patients with BPH and prostate cancer (PC). Furthermore, in studied groups we looked for a possible interrelationship between plasma concentrations of leptin and PSA. Material and methods. Conventional RT-PCR studies

Leptin receptor

10.5173/ceju.2009.02.art8

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322. Radioterapia pooperacyjna po radykalnej prostatektomii: wstępna ocena leczenia

Reports of Practical Oncology & Radiotherapy (2003)

Piotr Milecki Tomasz Stachowski Zbigniew Kwias

10.1016/s1507-1367(03)70805-0

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14/Pooperacyjna radioterapia po radykalnej prostatektomii: wstępna ocena metody leczenia

Reports of Practical Oncology & Radiotherapy (2004)