Sónia Teixeira

University of Coimbra

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João Gama

Universidade do Porto

Pedro Campos

Universidade do Porto

Bruno Veloso

Universidade do Porto

João Costa‐Rodrigues

Polytechnic Institute of Porto

Luı́s C. Branco

Universidade Nova de Lisboa

Maria Helena Fernandes

Rede de Química e Tecnologia

Miguel M. Santos

Rede de Química e Tecnologia

José Coelho Rodrigues

Universidade do Porto

James Nicholson

Stony Brook University Hospital

Jim Ridgway

Durham University

Cooperative Institutions

Universidade do Porto

INESC TEC

Rede de Química e Tecnologia

University of Coimbra

Hospitais da Universidade de Coimbra

University of Lisbon

Universidade Nova de Lisboa

Polytechnic Institute of Porto

Institute for Systems Engineering and Computers

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto

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Challenges of Data-Driven Decision Models: Implications for Developers and for Public Policy Decision-Makers

Design science and innovation (2022)

Sónia Teixeira José Coelho Rodrigues Bruno Veloso João Gama

10.1007/978-981-19-0412-7_7

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Citations (1)

Dose‐dependent inhibitory effects of proton pump inhibitors on human osteoclastic and osteoblastic cell activity

FEBS Journal (2013)

João Costa‐Rodrigues Sara Reis Sónia Teixeira Sandra Lopes Maria Helena Fernandes

Proton pump inhibitors (PPIs), a class of molecules that are used to decrease gastric acid production, might have adverse effects on bone metabolism. The aim of this study was to characterize the concentration-dependent and time-dependent effects of three PPIs (omeprazole, esomeprazole, and lansoprazole) on human osteoclast precursor cells isolated from peripheral blood, and on human mesenchymal stem cells (osteoblast precursors). Cell cultures were characterized for total protein content, apoptosis, and several osteoclastic/osteoblastic features, and also for the involvement of some intracellular signaling pathways. PPIs caused a dose-dependent decrease in cellular density, which correlated with an increase in the apoptosis rate, effects that became statistically significant at concentrations ≥ 10(-5) m. They also inhibited phenotype-related gene expression and functional parameters. For both cell types, cellular function, i.e. osteoclastic resorption and the formation of mineralized deposits by osteoblastic cells, was more affected than proliferation-related parameters. The three PPIs showed similar qualitative and quantitative effects, but displayed some differences in the underlying intracellular signaling pathways. These results suggest that PPIs might have a direct deleterious effect on bone cells, with the possibility of decreased bone turnover.

Lansoprazole

Bone remodeling

Bone cell

10.1111/febs.12478

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Citations (88)

Collective Intelligence and Collaboration: A Case Study in Airline Industry

IFIP advances in information and communication technology (2016)

Sónia Teixeira Pedro Campos Renato Fernandes Catarina Roseira

Flocking (texture)

Strategic alliance

Flock

10.1007/978-3-319-45390-3_13

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A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid

ChemMedChem (2019)

Sónia Teixeira Miguel M. Santos Ricardo Ferraz Cristina Prudêncio Maria Helena Fernandes

Novel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma.

Zoledronic Acid

10.1002/cmdc.201900397

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Citations (21)

Trustability in Algorithmic Systems Based on Artificial Intelligence in the Public and Private Sectors.

ERCIM news/ERCIM news online edition (2020)

Sónia Teixeira João Gama Pedro Amorim Gonçalo Figueira

Source

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Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma

Pharmaceutics (2020)

Sónia Teixeira Miguel M. Santos Maria Helena Fernandes João Costa‐Rodrigues Luı́s C. Branco

Herein the quantitative synthesis of eight new mono- and dianionic Organic Salts and Ionic Liquids (OSILs) from alendronic acid (ALN) is reported by following two distinct sustainable and straightforward methodologies, according to the type of cation. The prepared ALN-OSILs were characterized by spectroscopic techniques and their solubility in water and biological fluids was determined. An evaluation of the toxicity towards human healthy cells and also human breast, lung and bone (osteosarcoma) cell lines was performed. Globally, it was observed that the monoanionic OSILs showed lower toxicity than the corresponding dianionic structures to all cell types. The highest cytotoxic effect was observed in OSILs containing a [C2OHMIM] cation, in particular [C2OHMIM][ALN]. The latter showed an improvement in IC50 values of ca. three orders of magnitude for the lung and bone cancer cell lines as well as fibroblasts in comparison with ALN. The development of OSILs with high cytotoxicity effect towards the tested cancer cell types, and containing an anti-resorbing molecule such as ALN may represent a promising strategy for the development of new pharmacological tools to be used in those pathological conditions.

10.3390/pharmaceutics12030293

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Citations (26)

Interactive Data Visualizations for Teaching Civic Statistics

Springer eBooks (2022)

Jim Ridgway Pedro Campos James Nicholson Sónia Teixeira

10.1007/978-3-031-20748-8_5

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Citations (1)

Fatal Waterhouse-Friderichsen syndrome in an adult due to serogroup Y Neisseria meningitidis

BMJ Case Reports (2021)

Rúben Carvalho Fernando Guilhon Henriques Sónia Teixeira Paulo Coimbra

Waterhouse-Friderichsen syndrome (WFS), defined as severe adrenal insufficiency due to bilateral adrenal gland haemorrhagic necrosis, occurred in a 59-year-old woman. An underlying serogroup Y Neisseria meningitidis (NM) infection was diagnosed, with a rapid progression to purpura fulminans, disseminated intravascular coagulation and WFS. Intensive treatment including fluid resuscitation, broad-spectrum antibiotic therapy, ventilatory support, platelet and factor replacement were administered. The meningococcaemia in the presence of WFS had a fulminant progression, leading to a fatal outcome within 24 hours of symptom onset. This case details the diagnosis and management challenges of the WFS, a rare complication of NM septicaemia, and describes the identification of a NM serogroup that is rare in Portugal in middle-aged patients.

Purpura fulminans

Fulminant

10.1136/bcr-2020-238670

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Citations (2)

Tools for visualizing data: a review

Jim Ridgway James Nicholson Pedro Campos Sónia Teixeira

There has been an explosion in the range of tools available for presenting data, many of which are available to support statistics teaching. These include tools that allow users to ‘drag and drop’ data sets (e.g. RAW), tools designed to display particular data sets (e.g. eXplorer) and software libraries (e.g. D3.js). We report on a review of visualisation tools, where we have described the sorts of visualisations facilitated by each tool, along with features such as ease of use and cost. Data visualisations can give new insights into complex data sets, and can be used directly to reshape teaching. We map out teaching opportunities facilitated by different tool types. Understanding novel data visualisations has become an important element of statistical literacy, and so curricula should expose students to a wide variety of examples.

Data Exploration

10.52041/srap.17201

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Ethical and Technological AI Risks Classification: A Human Vs Machine Approach

Communications in computer and information science (2023)

Sónia Teixeira Bruno Veloso José Coelho Rodrigues João Gama

10.1007/978-3-031-23618-1_10

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