S Migasena

Mahidol University

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Pravan Suntharasamai

Bangkok Hospital

P Pitisuttitham

Mahidol University

Wichai Supanaranond

Mahidol Oxford Tropical Medicine Research Unit

Sriluck Simasathien

Phramongkutklao Hospital

B Prayurahong

Mahidol University

T Harinasuta

Mahidol Oxford Tropical Medicine Research Unit

P Migasena

Royal Society

Varunee Desakorn

Mahidol University

D Bunnag

Mahidol Oxford Tropical Medicine Research Unit

Punnee Pitisuttithum

Mahidol University

Cooperative Institutions

Mahidol University

Mahidol Oxford Tropical Medicine Research Unit

Armed Forces Research Institute of Medical Science

Walter Reed Army Institute of Research

Bangkok Hospital

Centers for Disease Control and Prevention

University of Oxford

Liverpool School of Tropical Medicine

University of Maryland, Baltimore

Johns Hopkins University

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Risk behaviours and comprehension among intravenous drug users volunteered for HIV vaccine trial.

PubMed (1997)

Punnee Pitisuttithum S Migasena A Laothai Pravan Suntharasamai C Kumpong

Out of 91 volunteers enrolled for the HIV vaccine trial, only 33 volunteers were eligible for vaccination. Of 33 volunteers recruited, 59 per cent of them had incomes of more than 5,000 Baht/ month. The median duration of drug addicts was 15 years (range 1-26 years) and 42 per cent never used condoms during sexual intercourse. As far as consent comprehension was concerned, all of them understood.With HIV seroprevalence rates of 35-40%, Thai intravenous drug users are an obvious target group for anti-HIV vaccine trials. The Ministry of Public Health of Thailand recently approved clinical trials of the Genentech MN rgp 120/HIV-1 candidate vaccine among recovering intravenous drug users enrolled in a methadone treatment center in Bangkok. To evaluate safety and immunogenicity factors and assemble a relatively low-risk group, 91 potential volunteers from this center were screened (history, physical examination, and blood and urine analysis). Only 33 passed all of the screening procedures; the major causes of ineligibility were HIV seropositivity (14 cases) and impaired liver function test (10 cases). The 33 eligibles had a median duration of drug addiction of 15 years. The majority had a secondary education or above and a monthly income exceeding 5000 Baht (US$200). Never-use of condoms was acknowledged by 14 of the eligible volunteers, but all 33 denied relationships with commercial sex workers. Among those selected for the trial, 23 believed a successful vaccine against AIDS is likely and 30 thought the vaccine they received was effective; however, 12 were concerned the vaccine would enhance disease progression. After 12 months of counseling and participation in the vaccine trial, nine volunteers were drug and methadone-free. Overall, these findings indicate that intravenous drug users can successfully participate in vaccine trials if there is adequate pre-screening.

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Citations (9)

Transient total blindness from quinine therapy

Annals of Tropical Medicine and Parasitology (1985)

S Migasena

"Transient total blindness from quinine therapy." Annals of Tropical Medicine & Parasitology, 79(1), pp. 109–110

Quinine

10.1080/00034983.1985.11811894

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Citations (1)

Studies inAncylostoma caninuminfection in dogs

Annals of Tropical Medicine and Parasitology (1972)

S Migasena H. M. Gilles B. G. Maegraith

Ancylostoma caninum

Ancylostoma

Parasitology

Hookworm Infections

10.1080/00034983.1972.11686803

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Citations (9)

Immunogenicity of two formulations of oral cholera vaccine comprised of killed whole vibrios and the B subunit of cholera toxin

Infection and Immunity (1989)

S Migasena Varunee Desakorn Pravan Suntharasamai P Pitisuttitham B Prayurahong

Two formulations of oral cholera vaccine were evaluated for safety and immunogenicity in adult volunteers in Thailand, an area with sporadic cholera outbreaks. One formulation consisted of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit, as was previously evaluated in North American volunteers, and the other consisted of 1 x 10(11) killed vibrios and 1 mg of B subunit, as was recently evaluated in a field trial in Bangladesh. Three doses of each formulation were given with citrate-bicarbonate buffer. Neither formulation had adverse effects. The formulations stimulated similar serum immunoglobulin G (IgG) and IgA responses to Vibrio cholerae lipopolysaccharide and cholera toxin and intestinal secretory IgA responses to lipopolysaccharide and toxin after three doses. The formulation containing twice the quantity of killed vibrios stimulated better vibriocidal responses, especially to Ogawa serotype. A formulation of oral vaccine containing more killed vibrios than were included in the vaccine studied in the Bangladesh field trial may provide greater protection against cholera.

Cholera vaccine

Cholera

Cholera toxin

El Tor

10.1128/iai.57.1.117-120.1989

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Citations (17)

Relationship of vibriocidal antibodies to history of cholera vaccination in Thai adult volunteers.

PubMed (1990)

Punee Pitisuttithum B Prayurahong S Migasena Pravan Suntharasamai

Vibriocidal antibodies were determined by microtechnique in 5 groups of Thai adult volunteers who had never received or had received cholera vaccination within one year, more than one to five years ago, more than five to ten years ago and more than ten years ago respectively. Detailed questionnaires about socioeconomic status, educational levels and environmental factors were presented to every volunteer. There were no differences statistically in incomes, educational levels and environmental factors among the groups. It was found that the reciprocal geometric mean titers of antibodies in volunteers who had never received cholera vaccination was generally low. The reciprocal geometric mean titers of the volunteers who had received cholera vaccination within one year were statistically different from other groups (p = 0.05). There was no correlation between blood groups of volunteers and vibriocidal antibodies.

Volunteer

Cholera

Cholera vaccine

Antibody titer

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Measles vaccination of Thai infants by intranasal and subcutaneous routes: possible interference from respiratory infections

Vaccine (1997)

Sriluck Simasathien S Migasena William J. Bellini R Samakoses P Pitisuttitham

Respiratory infection

10.1016/s0264-410x(97)00104-7

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Citations (18)

Experimental Ancylostoma caninum infection in dogs.

PubMed (1971)

S Migasena Gilles Hm Maegraith Bg

Ancylostoma caninum

Ancylostoma

Hookworm Infections

Ancylostomiasis

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Citations (2)

Adherence of human eosinophils to infective filariform larvae of Necator americanus in vitro.

PubMed (1987)

Varunee Desakorn Pravan Suntharasamai Sasithon Pukrittayakamee S Migasena D Bunnag

Eosinophilia is common in hookworm infection but the interaction between eosinophils and the larval stage of the parasite is poorly understood. The present study was conducted to test the ability of the eosinophils to adhere to infective filariform larvae of Necator americanus in vitro. Adherence of eosinophils to the larvae was found to be serum dependent. Antibody facilitated eosinophil adherence but this was maximal in the presence of complement. The adherence was greatly diminished by EGTA treated normal human serum (NHS) and was completely abolished when NHS was treated with either EDTA or heat-inactivation, suggesting that the process can be facilitated through complement activation via the alternative pathway. As with other nematodes, the surface of hookworm larvae appeared to be both antigenic and complement-activating. Although it is not known whether eosinophil adherence has any larvicidal effect, the present study demonstrated for the first time a definite interaction between human eosinophils and hookworm filariform larvae.

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Gnathostoma larva migrans among guests of a New Year party.

PubMed (1991)

S Migasena Punee Pitisuttithum Desakorn

An outbreak of Gnathostoma larva migrans occurred among guests of a New Year's party in Chachoengsao, Thailand. Nine people who consumed a raw fish dish called 'Hu-sae' contracted the disease. Five of them developed gastro-intestinal symptoms consisting of nausea, vomiting, abdominal cramps and diarrhea as early as within the first 24 hours, while in the other four, symptoms started on the following day. After the initial symptoms pertaining to the gut, malaise, chest discomfort, cough, myalgia, weakness, itching and migratory swellings were experienced. Eosinophilia was demonstrated in every patient with a mean (+/- SE) count of 5,516 +/- 1,010 cells/cu mm. Detection of antibody against aqueous extracts of G. spinigerum adult antigen using an enzyme-linked immunosorbent assay showed a titer of 1:1,600 or greater in every patients except one who had a titer of 1:400 (positive greater than or equal to 1:400). This outbreak illustrates the high attack rate when heavily infected fish are consumed.

myalgia

Mebendazole

Trichinosis

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Citations (7)

A case ofP. falciparummalaria in Thailand apparently resistant to quinine

Annals of Tropical Medicine and Parasitology (1980)

S Migasena D Bunnag T Harinasuta

"A case of P. falciparum malaria in Thailand apparently resistant to quinine." Annals of Tropical Medicine & Parasitology, 74(2), pp. 243–244

Quinine

Parasitology