Barbara Tringler

University of Salzburg

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Lukas Hefler

Convent Hospital of the Brothers of Saint John of God

Kenneth R. Shroyer

Stony Brook Medicine

Kathleen C. Torkko

University of Colorado Anschutz Medical Campus

Stefan Jirecek

Medical University of Vienna

Alexander Reinthaller

Vienna General Hospital

Jackie Papkoff

Edwards Lifesciences (United States)

Rainer Lehner

Medical University of Vienna

David Heinz

University of Colorado Denver

Nima Goharkhay

The University of Texas Medical Branch at Galveston

A. Staudach

Paracelsus Medical University

Cooperative Institutions

Medical University of Vienna

Universitätsklinik für Frauenheilkunde und Geburtshilfe

University of Vienna

Vienna General Hospital

University of Colorado Denver

University of Colorado Anschutz Medical Campus

Klinik für Frauenheilkunde

Comprehensive Cancer Center Vienna

Innsbruck Medical University

University of Colorado Health

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Risk of endometrial cancer in asymptomatic postmenopausal patients with thickened endometrium: data from the FAME-Endo study: an observational register study

Archives of Gynecology and Obstetrics (2018)

Lukas Hefler Judith Lafleur Sonja Kickmaier Heinz Leipold Carmen Siebenhofer

10.1007/s00404-018-4885-3

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Citations (17)

Pedigree analysis and descriptive investigation of three classic phenotypes associated with Holt-Oram syndrome.

PubMed (2003)

Rainer Lehner Nima Goharkhay Barbara Tringler Claudia Fasching Markus Hengstschläger

To determine the frequency of sporadic and familial cases of three classic phenotypes associated with Holt-Oran syndrome (HOS).We determined the frequency of sporadic and familial cases based on the 179 patients with HOS reported in the literature.Clinically, there are three variations of HOS: affected individuals may have only skeletal anomalies (27.4%), only cardiac defects (3.9%) or both (68.7%). Of the 179 affected individuals, 17.3% had sporadic and 82.7% had familial disease.The equal distribution between the sexes (female 53%, male 47%) indicates that HOS is transmitted as an autosomal dominant trait. In contrast to familial cases, cardiac involvement alone was not reported in any of the sporadic cases. When a cardiac malformation is diagnosed, the family members of the affected individual should be carefully screened for Holt-Oram syndrome.

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Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia

Human Pathology (2004)

Barbara Tringler Carol Gup Meenakshi Singh Steve D. Groshong A. Laurie Shroyer

Squamous metaplasia

Carcinoma in situ

Immunoperoxidase

10.1016/j.humpath.2004.02.012

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Citations (176)

Die Wertigkeit von Computertomographie in der präoperativen Beurteilung des Leisten-Lymphknotenstatus bei Patientinnen mit Vulvakarzinom

Geburtshilfe und Frauenheilkunde (2007)

Barbara Tringler Christine Grimm Stephan Polterauer Veronika Seebacher Alexander Reinthaller

Die komplette inguinale Lymphknotendissektion bei Patientinnen mit Vulvakarzinom geht mit einer hohen peri- und postoperativen Morbidität einher. Zahlreiche Versuche wurden unternommen, bereits präoperativ den Lymphknotenstatus besser einschätzen zu können. Bildgebende Verfahren wie die Computertomographie (CT) könnten diesbezüglich Bedeutung erlangen. Ziel der vorliegenden Studie ist es, die Wertigkeit des präoperativ durchgeführten CT als “Staging-Untersuchungen“ bei Patienten mit Vulvakarzinom zu evaluieren.

10.1055/s-2007-983539

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B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration

Gynecologic Oncology (2007)

Takashi Miyatake Barbara Tringler Wenhui Liu Shu‐Hui Liu Jackie Papkoff

Tumor-infiltrating lymphocytes

Endometrial hyperplasia

10.1016/j.ygyno.2007.03.039

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Citations (104)

Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma

Gynecologic Oncology (2005)

Barbara Tringler Christoph Grimm G. Sliutz Sepp Leodolter P Speiser

Thrombospondin 1

10.1016/j.ygyno.2005.05.038

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p16INK4a Expression in Invasive Vulvar Squamous Cell Carcinoma

Applied immunohistochemistry & molecular morphology (2007)

Barbara Tringler Christoph Grimm Grazyna Dudek Robert Zeillinger Clemens Tempfer

p16, a member of the INK4a family of cyclin-dependent kinase inhibitors, is known as a negative regulator of cell cycle progression and differentiation. Although p16 has been shown to be a promising biomarker for the detection of cervical intraepithelial neoplasia, few data have been published on vulvar cancer. Using immunohistochemistry, we evaluated the expression of p16 in 80 cases of invasive vulvar squamous cell carcinoma. Results were correlated with clinicopathologic parameters and survival data to determine the prognostic significance of p16 in vulvar cancer. p16 expression was detected in 34 of 80 (43%) cases of invasive vulvar squamous cell carcinoma. The expression was localized to the cytoplasm and the nuclei of the tumor cells. Correlations between p16 expression status and any clinicopathologic variables failed to be of statistical significance. In a univariate analysis, groin lymph node status, tumor stage, and tumor grade were associated with disease-free and overall survival, respectively. Patients positive for p16 expression showed a significantly longer disease-free and overall survival by univariate analysis. p16 expression was not associated with survival in a multivariate Cox-regression model. Our data add on those published in the literature and suggest that p16 may be of prognostic significance in invasive vulvar squamous cell carcinoma.

Vulvar Carcinoma

Expression (computer science)

10.1097/01.pai.0000213118.81343.32

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Placental insufficiency and maternal death caused by advanced stage of breast cancer in third trimester

European Journal of Obstetrics & Gynecology and Reproductive Biology (2001)

Rainer Lehner Heinz Strohmer Stefan Jirecek Nima Goharkhay Barbara Tringler

Placental insufficiency

HELLP syndrome

Third trimester

10.1016/s0301-2115(01)00393-1

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Immunohistochemical Localization of Survivin in Serous Tumors of the Ovary

Applied immunohistochemistry & molecular morphology (2004)

Barbara Tringler Rainer Lehner A. Laurie Shroyer Kenneth R. Shroyer

The aim of this study was to determine the immunohistochemical distribution of survivin in benign, borderline, and malignant serous tumors of the ovary. Survivin was localized by an indirect immunoperoxidase method in 42 cases of serous tumors of the ovary (15 cystadenomas, 15 borderline tumors, and 12 cystadenocarcinomas). Nuclear staining and cytoplasmic staining were separately scored. Cytoplasmic staining was detected in 27% of adenomas/borderline tumors and in 58% of carcinomas. Nuclear staining was detected in 87% of adenomas/borderline tumors but in only 42% of carcinomas. Although the differences in the intensity of cytoplasmic staining between adenomas and borderline tumors versus carcinomas were not significant, the differences in the intensity of nuclear staining between low-grade versus malignant tumors were significant. These findings suggest that survivin is widely expressed in benign, borderline, and malignant serous tumors but that nuclear localization of survivin is more common in benign or borderline tumors than in malignant serous tumors of the ovary. The molecular mechanisms that determine the subcellular distribution of this protein may reflect the role of survivin in the regulation of apoptosis during the processes of malignant transformation.

Survivin

Immunoperoxidase

Serous cystadenocarcinoma

10.1097/00129039-200403000-00008

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Citations (15)

Redistribution of corticotropin-releasing hormone receptor R2 using fluorescence immunohistochemistry in fetal membranes of women delivering preterm or at term.

PubMed (2002)

Stefan Jirecek Barbara Tringler Martin Knöfler Sandra Bauer Ata Topçuoğlu

Mesenchyme

Corticotropin-releasing hormone

Amniotic sac

Amnion

Receptor expression

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Citations (5)