Sander H. P. Driessen

Radboud University Medical Center

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Laurens F. M. Verscheijden

Radboud University Nijmegen

Marika A. de Hoop‐Sommen

Radboud University Nijmegen

Jolien J. M. Freriksen

Radboud University Nijmegen

Joyce E. M. van der Heijden

Radboud University Nijmegen

Lianne P. M. van Bussel

Radboud University Nijmegen

Saskia N. de Wildt

Radboud University Nijmegen

Rick Greupink

Radboud University Nijmegen

Anne E. M. Orlebeke

Radboud University Nijmegen

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Radboud University Nijmegen

Radboud University Medical Center

University Medical Center

Radboud Institute for Molecular Life Sciences

Utrecht University

University Medical Center Utrecht

Royal Dutch Pharmacists Association

Erasmus MC - Sophia Children’s Hospital

Queen's University

Brigham and Women's Hospital

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Feasibility of a Pragmatic PBPK Modeling Approach: Towards Model-Informed Dosing in Pediatric Clinical Care

Clinical Pharmacokinetics (2022)

Joyce E. M. van der Heijden Jolien J. M. Freriksen Marika A. de Hoop‐Sommen Lianne P. M. van Bussel Sander H. P. Driessen

More than half of all drugs are still prescribed off-label to children. Pharmacokinetic (PK) data are needed to support off-label dosing, however for many drugs such data are either sparse or not representative. Physiologically-based pharmacokinetic (PBPK) models are increasingly used to study PK and guide dosing decisions. Building compound models to study PK requires expertise and is time-consuming. Therefore, in this paper, we studied the feasibility of predicting pediatric exposure by pragmatically combining existing compound models, developed e.g. for studies in adults, with a pediatric and preterm physiology model.

10.1007/s40262-022-01181-8

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Citations (15)