Md. Abdul Aziz

University of Rajshahi

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Mohammad Safiqul Islam

Noakhali Science and Technology University

Sarah Jafrin

Noakhali Science and Technology University

Md Abdul Barek

Noakhali Science and Technology University

Md. Shalahuddin Millat

Noakhali Science and Technology University

Mohammad Sarowar Uddin

Noakhali Science and Technology University

Md. Saddam Hussain

Noakhali Science and Technology University

Masuda Begum

Bangabandhu Sheikh Mujib Medical University

Monzur Alam Imteaz

Swinburne University of Technology

Tahmina Akter

Noakhali Science and Technology University

Mohammad Shahriar

University of Asia Pacific

Cooperative Institutions

Noakhali Science and Technology University

University of Dhaka

Bangabandhu Sheikh Mujib Medical University

Dhaka Medical College and Hospital

University of Rajshahi

Bangladesh Agricultural University

University of Chittagong

University College London

Jahangirnagar University

North South University

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Knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students: A systematic review

Health Science Reports (2024)

Amanda Wondrasek Amber Fryza Md. Abdul Aziz Christine Leong Kaarina Kowalec

Abstract Background and Aims Pharmacists have been recognized as one of the most qualified healthcare professionals in the clinical implementation of pharmacogenomics, yet its widespread implementation in clinical pharmacy practice has remained limited. The review aims to systematically investigate knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students to inform the future delivery of pharmacogenomics education programs. Methods PubMed, MEDLINE, Embase, Scopus, and the International Pharmaceutical Abstracts were searched up to May 17, 2022. Studies were selected if they included data on pharmacists' or pharmacy students' knowledge, perception, or attitude about pharmacogenomics and were published in a peer‐reviewed, English‐language journal with full‐text availability. Any published study not deemed original research was excluded. All included studies were critically appraised using the Center for Evidence‐Based Management's critical appraisal tools. The data were descriptively analyzed and presented based on pharmacists' and pharmacy students' knowledge/awareness, perception/attitudes toward pharmacogenomic (PGx), confidence in using or interpreting PGx testing results, and their desire to get further PGx education or their most preferred method of further education. Results A combined total of 12,430 pharmacists and pharmacy students from 26 countries are represented in the 52 included studies. Despite overwhelmingly positive attitudes and perceptions toward pharmacogenomics among pharmacists and pharmacy students, an overall lack of adequate knowledge and confidence was found. The review also found a strong desire for further pharmacogenomics education among pharmacists and pharmacy students. Conclusion Pharmacists and pharmacy students have positive perceptions and attitudes toward pharmacogenomics, which is hindered by a lack of knowledge and confidence. However, inadequate control for confounders, limited representativeness of the studied population or region, and small sample sizes diminish the generalizability of the review results. Knowledge and confidence could be improved through enhanced delivery of pharmacogenomic courses within the pharmacy curriculum and continuing education programs.

Pharmacogenomics

10.1002/hsr2.1844

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Citations (9)

Elevated levels of pleiotropic interleukin-6 (IL-6) and interleukin-10 (IL-10) are critically involved with the severity and mortality of COVID-19: An updated longitudinal meta-analysis and systematic review on 147 studies

Sarah Jafrin Md. Abdul Aziz Mohammad Safiqul Islam

Review question / Objective: How were serum IL-6 and IL-10 linked with the severity and mortality of COVID-19 patients? To evaluate the role of IL-6 and IL-10 in the development of the severity or morality of COVID-19 patients. The outcomes (mean difference) were calculated between the severe vs. non-severe COVID-19 patients and non-survival vs. survival patients to evaluate the risk of severity or mortality. Condition being studied: Severity and mortality among the COVID-19 patients. Information sources: The international scientific authorized databases such as Google Scholar, PubMed, Embase, CNKI, Cochrane Library, and Web of science were used as primary sources to identify and collect the eligible literature. Additional secondary databases were also comprehensively searched to extract more related studies.

Web of science

2019-20 coronavirus outbreak

10.37766/inplasy2022.4.0046

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Association of rs363598 and rs360932 polymorphisms with autism spectrum disorder in the Bangladeshi children

Meta Gene (2020)

Md. Abdul Aziz Tahmina Akter Md. Saddam Hussain Md. Shalahuddin Millat Mohammad Sarowar Uddin

Association (psychology)

Heritability of autism

10.1016/j.mgene.2020.100733

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Could climate change exacerbate droughts in Bangladesh in the future?

Journal of Hydrology (2023)

Mahfuzur Rahman Md Sakib Hasan Tumon Md Monirul Islam Ningsheng Chen Quoc Bao Pham

10.1016/j.jhydrol.2023.130096

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Fixed Flowers

arXiv (Cornell University) (2023)

Md. Abdul Aziz Brittany Burdette John Mayer

Laminations are a combinatorial and topological way to study Julia sets. Laminations give information about the structure of parameter space of degree $d$ polynomials with connected Julia sets. We first study fixed point portraits in laminations and their respective global count. Then, we investigate the correspondence between locally unicritical laminations and locally maximally critical laminations with rotational polygons. The global correspondence has been shown in \cite{Burdette:2022}.

Julia set

Degree (music)

10.48550/arxiv.2307.15794

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TF and TCF4 gene polymorphisms are linked to autism spectrum disorder: a case–control study

Journal of International Medical Research (2022)

Maria Azmerin Md. Saddam Hussain Md. Abdul Aziz Md Abdul Barek Mobashera Begum

Although the prevalence of autism spectrum disorder (ASD) is increasing, appropriate diagnosis and prevention strategies are still lacking. This case-control study was designed to explore the association between ASD and the rs1867503 and rs9951150 polymorphisms of the TF and TCF4 genes, respectively.Ninety-six children with ASD and 118 healthy children were recruited and polymerase chain reaction-restriction fragment length polymorphism technique was applied for genotyping.The frequencies of the mutant allele G were 48% and 44% for the rs1867503 and rs9951150 polymorphisms, respectively. In our analysis, both TF and TCF4 polymorphisms were associated with an increased risk of developing ASD. AG heterozygotes (OR = 3.18), GG mutant homozygotes (OR = 2.62), AG + GG combined genotypes (OR = 2.98), and G mutant alleles of TF rs1867503 (OR = 1.94) were associated with a significantly elevated risk of ASD. Likewise, AG heterozygotes (OR = 2.92), GG mutant homozygotes (OR = 2.36), AG + GG combined genotypes (OR = 2.72), and G minor alleles of TCF4 rs9951150 (OR = 1.92) were associated with a significantly elevated risk of ASD.Our results indicate that TF rs1867503 and TCF4 rs9951150 polymorphisms may be strongly associated with the development of ASD in Bangladeshi children.

Heterozygote advantage

Minor allele frequency

Compound heterozygosity

10.1177/03000605221138492

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Impact of interleukin-32 germ-line rs28372698 and intronic rs12934561 polymorphisms on cancer development: A systematic review and meta-analysis

International Immunopharmacology (2021)

Sarah Jafrin Md. Abdul Aziz Mohammad Safiqul Islam

Subgroup analysis

genetic model

10.1016/j.intimp.2021.107964

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Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis

Molecular Genetics & Genomic Medicine (2022)

Md. Abdul Aziz Mohammad Safiqul Islam

Abstract Background ACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms could play a critical role in altering the clinical outcomes of SARS‐CoV‐2. The findings of previous studies remained inconclusive. This meta‐analysis was performed to evaluate the association and provide a more reliable outcome. Methods This study was completed following the updated recommendations of PRISMA using RevMan 5.4.1 statistical software. Results A total of 11 studies with 950 severe cases and 1573 non‐severe cases with COVID‐19 infection were included. Pooled analysis showed that ACE1 I/D polymorphism was correlated with the severity of SARS‐CoV‐2 in the DD genotype and D allele for the fixed‐effects model (OR:1.27 and OR:1.17). Besides, codominant 3, recessive, and allele models were associated with the severity of the fixed‐effects model (OR:1.35, OR:1.37, and OR:1.20) in Caucasian ethnicity. ACE2 rs2285666 was linked with the severity in codominant 3 (OR:2.63, for both random‐ and fixed effects‐models), overdominant (OR:1.97, for random‐effects model and OR:1.97, for fixed effects‐model), and recessive model (OR:0.41 for fixed‐ and random‐effects model). Allele model of rs2285666 showed a significant association in the fixed‐effects model (OR:1.61). Conclusion Our present meta‐analysis suggests that ACE1 I/D rs1799752 and ACE2 rs2285666 variants may enhance the severity in SARS‐CoV‐2 infected patients. Future studies are warranted to verify our findings.

genetic model

2019-20 coronavirus outbreak

10.1002/mgg3.2063

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Electrochemical Selective Nitrate Reduction: Pathways to Nitrogen and Ammonia Production

The Chemical Record (2024)

Mofidul Islam S. M. Abu Nayem Syed Shaheen Shah Md. Zahidul Islam Md. Abdul Aziz

Abstract Nitrate (NO 3 − ) contamination from industrial, agricultural, and anthropogenic activities poses significant risks to human health and ecosystems. While traditional NO 3 − remediation methods are effective, they often generate secondary pollutants and incur high costs. Electrochemical NO 3 − reduction (ECNR) offers a sustainable alternative, converting NO 3 − into environmentally benign nitrogen (N 2 ) or valuable ammonia (NH 3 ). This review explores recent advancements in selective ECNR pathways for NO 3 − ‐to‐N 2 and NO 3 − ‐to‐NH 3 conversion, focusing on mechanistic insights, electrocatalyst development, and optimization strategies. Key factors influencing ECNR performance, such as electrode materials, electrolyte composition, and hydrogen evolution inhibition, are discussed. Additionally, the review highlights the role of single‐atom, bimetallic, and nanostructured catalysts in enhancing faradaic efficiency, total N 2 removal, and selectivity, with particular attention to Pd−Cu systems. Strategies to address challenges like low selectivity and catalyst degradation are also explored. This review underscores the potential of ECNR as a viable alternative to the energy‐intensive Haber‐Bosch process for NH 3 production, aligning with global sustainability goals. Finally, we identify research gaps and propose future directions for improving the efficiency, stability, and scalability of ECNR technologies.

10.1002/tcr.202400206

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A New Approach of Bernoulli Sub-ODE Method to Solve Nonlinear PDEs

American Scientific Research Journal for Engineering, Technology, and Sciences (2018)

Md. Abdus Salam Md. Shafiqul Islam Md. Hamidul Islam Md. Abdul Aziz

In this paper, a new approach of the Bernoulli Sub-ODE method is proposed and this method is applied to solve the modified Liouville equation and the regularized long wave equation. As a result some new traveling wave solutions for them are successfully established. When the parameters are taken as special values, the solitary wave solutions are originated from these traveling wave solutions. Further, graphical representation of some solutions are given to visualize the dynamics of the equation. The results reveal that this method may be useful for solving higher order nonlinear partial differential equations.

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Bernoulli differential equation

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