A Toshkov

Bulgarian Academy of Sciences

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Co-Authors

L Shirova

D Georgiev

Plovdiv University

J. Gumpert

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

E Slavcheva

Temple College

K Noeva

Bulgarian Academy of Sciences

M Matev

ТТ

Т. Тодоров

Bulgarian Academy of Sciences

D Velianov

Bulgarian Academy of Sciences

G Sheĭkova

Chemical Pharmaceutical Research Institute

Shabanov Ma

Ministry of Health of the Russian Federation

Cooperative Institutions

Bulgarian Academy of Sciences

Czech Academy of Sciences, Institute of Microbiology

Russian Academy of Sciences

Medical University Plovdiv

Saints Cyril and Methodius University of Skopje

Trakia University

Institute of Molecular Biotechnology

Agrobioinstitute

Institute of Molecular Biology

Institute of Organic Chemistry with Centre of Phytochemistry

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[Persistence and reversion of stable L forms of Proteus mirabilis in white mice].

PubMed (1977)

A Toshkov A Kuiumdzhiev I Gumpert D Sotirova

Reversion

Persistence (discontinuity)

White (mutation)

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Citations (1)

[Controlled postpenicillin enterocolitis in guinea pigs caused by E. coli W1655 F+].

PubMed (1980)

Ilia P Mitov A Toshkov

Enterocolitis

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Light microscopic investigations on lysozyme‐ and penicillin‐induced morphological changes in Erysipelothrix rhusiopathiae and on propagation of its protoplast type L‐form

Zeitschrift für allgemeine Mikrobiologie (1980)

J. Gumpert Т. Тодоров A Toshkov

Although lysozyme and penicillin are different in their molecular action on cell wall murein they produce similar morphological changes in Erysipelothrix rhusiopathiae grown on agar media. 2,000--5,000 micrograms/ml lysozyme and 0.1--2 IU/ml penicillin induce filament formation. Filaments are able to divide in rods, which shows that only cross wall formation and separation are inhibited. Higher doses of lysozyme (10,000 micrograms/ml) and penicillin (less than 1 IU/ml) inhibit cell wall synthesis and induce L-form growth. The propagation of this protoplast type L-form was investigated by microphotographic series in phase contrast microscope during L-form induction and in the stable L-form state. In both cases L-form cells propagate by formation and growth of small granular elements of about 0.2--0.6 micrometers in diameter, which spread in different directions in the agar medium. The multiplication process may be explained by the plasticity and flexibility of the L-form cell and its cytoplasmic membrane and by the structural and functional interaction between the "folded chromosome" and the surrounding cytoplasm.

Protoplast

Erysipelothrix rhusiopathiae

10.1002/jobm.19800200702

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Citations (4)

[Effect of cholesterin on certain toxic antibiotics with special reference to gramicidin C].

PubMed (1953)

V MARKOV A Toshkov

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[Influence of etiotropic therapy on the relationships between micro- and macroorganisms. 3. Chloramphenicol treatment of salmonellosis among sheep].

PubMed (1965)

A Toshkov I Karadzhov L Shirova E Slavcheva

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[Enhanced nonspecific anti-infective resistance to Klebsiella pneumoniae in mice immunostimulated with preparations P-84 and P-85].

PubMed (1985)

A Toshkov Dimov

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[Bacteriological force of lysozyme in tears in normal conditions and in eye diseases].

PubMed (1955)

A Toshkov T Elenkov

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[Sensitization of guinea pigs with L and S forms of Proteus mirabilis D52].

PubMed (1982)

A Toshkov B Kenarova Е В Иванова I Gumpert

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[Experimental Erysipelothrix insidiosa infection in lambs].

PubMed (1976)

A Toshkov D Velianov D Georgiev T Todorov L Shirova

Erysipelothrix rhusiopathiae

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[Effect of the pesticide carbaryl (sevin) on the course of experimental Erysipelothrix rhusiopathiae infection in rats].

PubMed (1983)

Shabanov Ma A Toshkov D Georgiev N Ibrishimov

Rats treated with carbaril (sevin) at the rate of 2 to 5 mg were infected via the feed with Erysipelothrix rhusiopathiae in the course of 30 days. Studied were the clinical picture, some paraclinical indices, the mortality rate, and the morphologic and histopathologic changes in the parenchymal organs. It was found that rats that were given carbaril for a long time in minimum amounts and were then subjected to infection developed a characteristic clinical picture and showed a high mortality rate (nearly twice as high as that with the control animals). In hemocultures the causative agent was isolated over a longer period than in the case with the controls. Both the gross and the histopathologic findings were more strongly manifested in the test (carbaril-treated) rats.

Erysipelothrix rhusiopathiae

Carbaryl

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